RPS8 - ribosomal protein S8 Gene

Also Known as S8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6202

About RPS8

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:44,775,540-44,778,779 (from NCBI)

This gene has 8 transcripts (splice variants) and 233 orthologues. Ubiquitous expression in ovary (RPKM 2095.9), bone marrow (RPKM 913.3) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS8 Products (1)

mRNA Protein Name
NM_001012.2 NP_001003.1 40S ribosomal protein S8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
30021884 GOA
enables structural constituent of ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
Biological Process GO Annotation Evidence References Source
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosolic ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
part of cytosolic small ribosomal subunit IDA
IDA: Inferred from direct assay
8706699 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
17289661 GOA
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS8 Protein Structure

Ribosomal_S8e

Ribosomal_S8e: Ribosomal protein S8e (1 - 190)

  • 0
  • 100
  • 208 a.a.
Protein Preferred Names Protein Names

40S ribosomal protein S8

  • OK/SW-cl.83

RPS8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPS8 P62241 DLG2 Homo sapiens Q15700
Y2H Prey Pooling
32296183
Intra
RPS8 P62241 DLG2 Homo sapiens Q15700
Validated Y2H
32296183
Intra
RPS8 P62241 DLG2 Homo sapiens Q15700
Y2H Array
32296183
Intra
RPS8 P62241 DLG3 Homo sapiens Q92796
Y2H Prey Pooling
32296183
Intra
RPS8 P62241 DLG3 Homo sapiens Q92796
Validated Y2H
32296183
Intra
RPS8 P62241 DLG3 Homo sapiens Q92796
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

RPS8 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83475 RPS8 Antibody (YA3220) WB, ICC/IF, FC, IP Human, Mouse, Rat
HY-P83475A RPS8 Antibody (YA3220)(PBS only) WB, ICC/IF, FC, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Theileriasis

  • Theileriosis

  • Infection By Theileria
Babesiosis

  • Babesiasis

  • Infection By Babesia

  • Piroplasmosis

  • Human Babesiosis

  • Babesia Parasite Infection

  • Piroplasma Infection
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12270 RPS8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RPS8 VGNC VGNC:34151
Rattus norvegicus RPS8 RGD RGD:61910
Macaca mulatta RPS8 VGNC VGNC:106490
Mus musculus RPS8 MGD MGI:98166
Canis familiaris RPS8 VGNC VGNC:103702
Felis catus RPS8 VGNC VGNC:107615
Others RPS8 NCBI