CCL1 - C-C motif chemokine ligand 1 Gene

Also Known as P500; SISe; TCA3; I-309; SCYA1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6346

About CCL1

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:34,360,328-34,363,233 (from NCBI)

This gene has 1 transcript (splice variant), 38 orthologues and 25 paralogues. Low expression observed in reference dataset.

Summary

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]

CCL1 Products (1)

mRNA Protein Name
NM_002981.2 NP_002972.1 C-C motif chemokine 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chemokine activity IDA
IDA: Inferred from direct assay
1557400 GOA
Biological Process GO Annotation Evidence References Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
12949249 GOA
involved in killing of cells of another organism IDA
IDA: Inferred from direct assay
12949249 GOA
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
1557400 GOA
involved in positive regulation of inflammatory response IDA
IDA: Inferred from direct assay
28972028 GOA
involved in positive regulation of interleukin-17 production IDA
IDA: Inferred from direct assay
28972028 GOA
involved in positive regulation of monocyte chemotaxis IDA
IDA: Inferred from direct assay
1557400 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
1557400 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL1 Protein Structure

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (31 - 87)

  • 0
  • 96 a.a.
Protein Preferred Names Protein Names

C-C motif chemokine 1

  • T lymphocyte-secreted protein I-309

Recombinant CCL1 Proteins

Cat. No. Product Name Accession Purity
HY-P7198 I-309/CCL1 Protein, Human (CHO) P22362 (K24-K96) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70463 I-309/CCL1 Protein, Human P22362 (K24-K96) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73914 I-309/CCL1 Protein, Human (HEK293, Fc) P22362 (K24-K96) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Kaposi Sarcoma

  • Kaposi'S Sarcoma

  • Kaposi Sarcoma, Susceptibility To

  • Kaposi'S Sarcoma Of Lung

  • Kaposi'S Sarcoma Of Palate

  • Kaposi'S Sarcoma Of Soft Tissue

  • Kaposi'S Sarcoma-Associated Herpesvirus

  • Multiple Idiopathic Pigmented Hemangiosarcoma

  • Multiple Idiopathic Pigmented Hemangiosarcoma, Susceptibility To

  • African Lymphadenopathic Kaposi'S Sarcoma

  • Anal Kaposi'S Sarcoma

  • Cardiac Kaposi'S Sarcoma

  • Central Nervous System Kaposi'S Sarcoma

  • Conjunctival Kaposi'S Sarcoma

  • Corneal Kaposi'S Sarcoma

  • Cutaneous Kaposi'S Sarcoma

  • Esophageal Kaposi'S Sarcoma

  • Gallbladder Kaposi'S Sarcoma

  • Gastric Kaposi'S Sarcoma

  • Intestinal Kaposi'S Sarcoma

  • Kaposi'S Sarcoma Of Anus

  • Kaposi'S Sarcoma Of Central Nervous System

  • Kaposi'S Sarcoma Of Conjunctiva

  • Kaposi'S Sarcoma Of Cornea

  • Kaposi'S Sarcoma Of Esophagus

  • Kaposi'S Sarcoma Of Gastrointestinal Sites

  • Kaposi'S Sarcoma Of Heart

  • Kaposi'S Sarcoma Of Lymph Nodes

  • Kaposi'S Sarcoma Of Penis

  • Kaposi'S Sarcoma Of Skin

  • Kaposi'S Sarcoma Of Soft Tissues

  • Kaposi'S Sarcoma Of The Cns

  • Kaposi'S Sarcoma Of The Gallbladder

  • Kaposi'S Sarcoma Of The Prostate

  • Kaposi'S Sarcoma, Lung

  • Kaposi'S Sarcoma, Skin

  • Lymph Node Kaposi'S Sarcoma

  • Lymphadenopathic Kaposi'S Sarcoma

  • Palate Kaposi'S Sarcoma

  • Penis Kaposi'S Sarcoma

  • Prostate Kaposi'S Sarcoma

  • Pulmonary Kaposi'S Sarcoma

  • Soft Tissue Kaposi'S Sarcoma

  • Hhv8

  • Human Herpesvirus 8

  • Kshv

  • Kaposi Sarcoma Herpesvirus

  • Mediterranean Kaposi Sarcoma

  • Non Aids Related Kaposi Sarcoma

  • Sarcoma, Kaposi

  • Sarcoma, Kaposi, Susceptibility To

  • Non-Aids-Related Kaposi Sarcoma

  • Angiolymphoid Hyperplasia

  • Angiofollicular Ganglionic Hyperplasia

  • Multi-Centric Castleman'S Disease
Diamond-Blackfan Anemia 8

  • DBA8

  • Rps7-Related Diamond-Blackfan Anemia

  • Anemia, Diamond-Blackfan, Type 8
Mast-Cell Leukemia

  • Mast Cell Leukemia

  • Leukemia, Mast-Cell

  • Leukemia Mast Cell

  • Mast Cell Leukaemia Nos

  • Mast Cell Leukaemia Without Mention Of Remission
Perianal Hematoma

  • External Thrombosed Haemorrhoids

  • Thrombosed External Hemorrhoids
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Malaria

  • Malaria, Susceptibility To

  • Malaria, Resistance To

  • Malaria, Cerebral

  • Cerebral Malaria

  • Malaria, Severe, Susceptibility To

  • Malaria, Severe, Resistance To

  • Malaria, Cerebral, Susceptibility To

  • Induced Malaria

  • Malaria, Vivax, Protection Against

  • Malaria, Severe

  • Malaria, Cerebral, Reduced Risk Of

  • Malaria, Protection Against

  • Resistance To Malaria Due To G6pd Deficiency

  • Malaria Due To G6pd Deficiency

  • Malarial Encephalitis

  • CM

  • Malaria Cerebral

  • Susceptibility To Malaria

  • Acute Pernicious Fever

  • Aestivo-Autumnal Fever

  • Aestivo Autumnal Malaria

  • Chagres Fever

  • Continued Malaria Fever

  • Estivo-Autumnal Fever

  • Estivo-Autumnal Malaria

  • Estivo-Autumnal Malarial Fever

  • Falciparum Fever

  • Malignant Tertian Fever

  • Malignant Tertian Malaria

  • Pernicious Intermittent Fever

  • Pernicious Malaria

  • Quotidian Malaria

  • Subtertian Fever

  • Subtertian Malaria Fever

  • Subtertian Malignant Tertian Malaria

  • Tropical Malaria

  • Algid Malaria

  • Bilious Haemoglobinuric Fever

  • Black Water Fever

  • Blackwater Fever

  • Malarial Blackwater Fever

  • Severe Malarial Falciparum

  • West African Fever

  • Malarial Haematinuria

  • Haemoglobinuric Fever

  • Haemoglobinuric Malaria

  • Severe Plasmodium Falciparum Malaria

  • Malarial Haemoglobinuria

  • Malarial Haematuria

  • Falciparum Malaria [Malignant Tertian]

  • Malaria Tropica

  • Malarial Shock

  • Chagres Virus Disease

  • Malignant Malaria

  • Mtm - [Malignant Tertian Malaria]

  • Tm -[Malignant Tertian Malaria]

  • Panama Fever

  • St - [Subtertian Malaria]

  • Malarial Quotidian

  • Benign Tertian Malaria

  • Tertian Ague

  • Vivax Fever

  • Plasmodium Vivax Malaria Nos

  • Btm - [Benign Tertian Malaria]

  • Bt - [Benign Tertian Malaria]

  • Vivax Malaria

  • Benign Tertian Vivax Malaria

  • Tertian Malaria

  • Quartan Malaria

  • Quartan Ague

  • Quartan Fever

  • Plasmodium Malariae Malaria Nos

  • Quartan Malarial

  • Malaria By Plasmodium Malariae

  • Malariae Malaria

  • Ovale Tertian Malaria

  • Plasmodium Ovale Fever

  • Malaria Fever By Plasmodium Ovale

  • Ovale Malaria

  • Malaria By Plasmodium Ovale

  • Malarial Ovale

  • Marsh Fever

  • Remittent Congestive Fever

  • Coastal Fever

  • Remittent Gastric Fever

  • Miasmatic Fever

  • Congestive Remittent Fever

  • Intermittent Fever

  • Jungle Fever

  • Paludism

  • Cameroon Fever

  • Ague

  • Corsican Fever

  • Intermittent Bilious Fever

  • Disease Due To Plasmodiidae

  • Malarial Fever

  • Plasmodiosis

  • Remittent Fever

  • Roman Fever

  • Malaria Fever Nos

  • Malaria Nos

  • Paludal Fever

  • Clinically Diagnosed Malaria

  • Clinically Diagnosed Malaria Without Parasitological Confirmation

  • Congestive Fever

  • Malarial Cachexia

  • Marsh Cachexia

  • Paludal Cachexia

  • Recurrent Malaria

  • Remittent Malaria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P990914 Denikitug 99.00% Phase 2
HY-P991944 ZL-1218 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122219 R243 Antagonist 98.09% Unkown
HY-124416 ML604086 Inhibitor 99.78% Unkown
HY-144197 CCR8 antagonist 1 Antagonist 99.50% Unkown
HY-RS02080 CCL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174772 Human CCL1 mRNA / Unkown
HY-RS16818 Ccl1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23259 Ccl1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CCL1 VGNC VGNC:38880
Bos taurus CCL1 VGNC VGNC:26943
Mus musculus CCL1 MGD MGI:98258
Rattus norvegicus CCL1 RGD RGD:1586495
Macaca mulatta CCL1 VGNC VGNC:70694
Others CCL1 NCBI