CCL15 - C-C motif chemokine ligand 15 Gene

Also Known as LKN1; NCC3; SY15; HCC-2; LKN-1; MIP-5; NCC-3; SCYL3; MIP-1D; MRP-2B; SCYA15; HMRP-2B; MIP-1 delta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6359

About CCL15

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:35,997,582-36,001,553 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 141 orthologues and 25 paralogues. Biased expression in colon (RPKM 21.9), small intestine (RPKM 21.7) and 6 other tissues.

Summary

This gene is located in a cluster of similar genes in the same region of chromosome 17. These genes encode CC cytokines, which are secreted proteins characterized by two adjacent cysteines. The product of this gene is chemotactic for T cells and monocytes, and acts through C-C Chemokine Receptor type 1 (CCR1). The proprotein is further processed into numerous smaller functional peptides. Naturally-occurring readthrough transcripts occur from this gene into the downstream gene, CCL14 (chemokine (C-C motif) ligand 14). [provided by RefSeq, Jan 2013]

CCL15 Products (1)

mRNA Protein Name
NM_032965.6 NP_116741.2 C-C motif chemokine 15 preproprotein

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables chemoattractant activity IDA
IDA: Inferred from direct assay
15001559 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL15 Protein Structure

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (51 - 108)

  • 0
  • 100
  • 113 a.a.
Protein Preferred Names Protein Names

C-C motif chemokine 15

  • chemokine (C-C motif) ligand 15

Recombinant CCL15 Proteins

Cat. No. Product Name Accession Purity
HY-P7266 MIP-5/CCL15 Protein, Human Q16663 (Q22-I113) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73812 MIP-5/CCL15 Protein, Human (68a.a, His) Q16663 (S46-I113) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Asymptomatic Neurosyphilis

  • Neurosyphilis

  • Neurosyphilis, Asymptomatic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02084 CCL15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174768 Human CCL15 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CCL15 RGD RGD:1310563