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CCL16 - C-C motif chemokine ligand 16 Gene

Also Known as LEC; LMC; NCC4; CKb12; HCC-4; LCC-1; Mtn-1; NCC-4; SCYL4; ILINCK; SCYA16

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6360

About CCL16

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:35,976,499-35,981,497 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 91 orthologues and 25 paralogues. Biased expression in liver (RPKM 21.1) and spleen (RPKM 0.6).

Summary

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10. [provided by RefSeq, Jul 2008]

CCL16 Products (1)

mRNA	Protein	Name
NM_004590.4	NP_004581.1	C-C motif chemokine 16 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables chemoattractant activity	IDA IDA: Inferred from direct assay	15001559	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28381538	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCL16 Protein Structure

IL8

0
100
120 a.a.

Protein Preferred Names	Protein Names
C-C motif chemokine 16	IL-10-inducible chemokine

CCL16 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	CCL16	O15467	CCL5	Homo sapiens	P13501	SPR	28381538
Intra	CCL16	O15467	CCL5	Homo sapiens	P13501	Filter Binding	28381538
Intra	CCL16	O15467	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	CCL16	O15467	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	CCL16	O15467	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CCL16 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P7196	HCC-4/CCL16 Protein, Human (CHO)	O15467 (Q24-Q120)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7197	HCC-4/CCL16 Protein, Human	O15467 (Q24-Q120)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Ring Dermoid Of Cornea	RDC Ring Dermoid Syndrome Bilateral, Annular Limbal Dermoids With Corneal And Conjunctival Extension Dermoid Of Cornea, Ring
Cataract 18	Cataract, Autosomal Recessive Congenital 2 Catc2 CTRCT18 Autosomal Recessive Congenital Cataract 2 Cataract 18, Autosomal Recessive Cataract 18 Autosomal Recessive Cataract, Type 18
Leber Congenital Amaurosis 1	LCA1 Amaurosis Congenita Of Leber I Lca Retinal Blindness, Congenital Crb Leber Congenital Amaurosis Type I Leber Congenital Amaurosis, Type 1 Amaurosis Congenita Of Leber, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS02085	CCL16 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174723	Human CXCR6 mRNA		/	Unkown
HY-174767	Human CCL16 mRNA		/	Unkown