NCAPG - non-SMC condensin I complex subunit G Gene

Also Known as CAPG; CHCG; YCG1; NY-MEL-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64151

About NCAPG

Cytogenetic location: 4p15.31 Genomic coordinates (GRCh38): 4:17,810,979-17,844,865 (from NCBI)

This gene has 5 transcripts (splice variants) and 206 orthologues. Broad expression in bone marrow (RPKM 7.5), lymph node (RPKM 7.1) and 21 other tissues.

Summary

This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during Mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

NCAPG Products (1)

mRNA	Protein	Name
NM_022346.5	NP_071741.2	condensin complex subunit 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12138188	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitotic chromosome condensation	IDA IDA: Inferred from direct assay	11136719	GOA
involved in positive regulation of chromosome condensation	IDA IDA: Inferred from direct assay	17268547	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of condensin complex	IDA IDA: Inferred from direct assay	11136719	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCAPG Protein Structure

Cnd3

0
200
400
600
800
1015 a.a.

Protein Preferred Names	Protein Names
condensin complex subunit 3	XCAP-G homolog

NCAPG Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NCAPG	Q9BPX3	NCAPD2	Homo sapiens	Q15021	TAP	24981860
Intra	NCAPG	Q9BPX3	NCAPD2	Homo sapiens	Q15021	Anti Bait CoIP	17268547
Intra	NCAPG	Q9BPX3	NCAPH	Homo sapiens	Q15003	Anti Bait CoIP	17268547
Intra	NCAPG	Q9BPX3	NCAPH	Homo sapiens	Q15003	TAP	24981860
Intra	NCAPG	Q9BPX3	ARRDC1	Homo sapiens	Q8N5I2	Anti Tag CoIP	33961781
Intra	NCAPG	Q9BPX3	ARRDC1	Homo sapiens	Q8N5I2	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09068	NCAPG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09069	NCAPG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20998	Ncapg Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27515	Ncapg Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NCAPG	VGNC	VGNC:31903
Canis familiaris	NCAPG	VGNC	VGNC:43641
Felis catus	NCAPG	VGNC	VGNC:63732
Macaca mulatta	NCAPG	VGNC	VGNC:75014
Mus musculus	NCAPG	MGD	MGI:1930197
Rattus norvegicus	NCAPG	RGD	RGD:1562646
Others	NCAPG	NCBI