DPEP2 - dipeptidase 2 Gene

Also Known as MBD2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64174

About DPEP2

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,987,390-68,000,619 (from NCBI)

This gene has 9 transcripts (splice variants), 199 orthologues and 2 paralogues. Broad expression in spleen (RPKM 6.2), lymph node (RPKM 3.2) and 14 other tissues.

Summary

DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These Enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some Antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]

DPEP2 Products (3)

mRNA Protein Name
NM_001324159.2 NP_001311088.1 dipeptidase 2 isoform 2
NM_001369657.1 NP_001356586.1 dipeptidase 2 isoform 1 precursor
NM_022355.4 NP_071750.1 dipeptidase 2 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables dipeptidase activity IDA
IDA: Inferred from direct assay
32325220 GOA
Biological Process GO Annotation Evidence References Source
involved in leukotriene D4 catabolic process IDA
IDA: Inferred from direct assay
32325220 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPEP2 Protein Structure

Peptidase_M19

Peptidase_M19: Membrane dipeptidase (Peptidase family M19) (79 - 399)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 486 a.a.
Protein Preferred Names Protein Names

dipeptidase 2

Recombinant DPEP2 Proteins

Cat. No. Product Name Accession Purity
HY-P76305 DPEP2 Protein, Human (HEK293, Fc) AAH24021.1 (A33-S376) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P76306 DPEP2 Protein, Human (HEK293, His) Q9H4A9-2 (A33-S376) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Leukoencephalopathy, Cystic, Without Megalencephaly

  • Cystic Leukoencephalopathy Without Megalencephaly

  • Rnaset2-Deficient Cystic Leukoencephalopathy

  • Rnase T2-Deficient Leukoencephalopathy

  • Clwm

  • Leukoencephalopathy With Bilateral Anterior Temporal Lobe Cysts

  • Infantile-Onset Rnaset2 Deficient Cystic Leukoencephalopathy

  • Lbatc

  • LCWM
Prolidase Deficiency

  • Hyperimidodipeptiduria

  • Imidodipeptidase Deficiency

  • Peptidase Deficiency

  • PD

  • Deficiency Of Prolidase

  • Imidodipeptiduria

  • Proline Dipeptidase Deficiency
Hermansky-Pudlak Syndrome 7

  • HPS7

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

  • Delta Storage Pool Disease

  • Hermansky-Pudlak Syndrome, Type 7

  • Platelet Storage Pool Deficiency

  • Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11879 LSALT peptide Inhibitor / Unkown
HY-RS03948 DPEP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18658 Dpep2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25144 Dpep2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DPEP2 RGD RGD:1305746
Bos taurus DPEP2 VGNC VGNC:52193
Macaca mulatta DPEP2 VGNC VGNC:71882
Mus musculus DPEP2 MGD MGI:2442042
Others DPEP2 NCBI