DEPTOR - DEP domain containing MTOR interacting protein Gene

Also Known as DEP.6; DEPDC6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64798

About DEPTOR

Cytogenetic location: 8q24.12 Genomic coordinates (GRCh38): 8:119,873,722-120,050,918 (from NCBI)

This gene has 3 transcripts (splice variants), 210 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 29.3), adrenal (RPKM 13.7) and 17 other tissues.

Summary

Involved in several processes, including negative regulation of TOR signaling; negative regulation of cell size; and negative regulation of protein kinase activity. [provided by Alliance of Genome Resources, Apr 2022]

DEPTOR Products (2)

mRNA Protein Name
NM_001283012.2 NP_001269941.1 DEP domain-containing mTOR-interacting protein isoform 2
NM_022783.4 NP_073620.2 DEP domain-containing mTOR-interacting protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidic acid binding IDA
IDA: Inferred from direct assay
25936805 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19446321 GOA
enables protein kinase inhibitor activity IDA
IDA: Inferred from direct assay
22017875 GOA
enables protein serine/threonine kinase inhibitor activity IDA
IDA: Inferred from direct assay
22017875 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
19446321 GOA
involved in negative regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
22017875 GOA
involved in negative regulation of TORC1 signaling IGI
IGI: Inferred from genetic interaction
33110214 GOA
involved in negative regulation of TORC2 signaling IDA
IDA: Inferred from direct assay
25936805 GOA
involved in negative regulation of TORC2 signaling IGI
IGI: Inferred from genetic interaction
33110214 GOA
involved in negative regulation of cell size IMP
IMP: Inferred from mutant phenotype
19446321 GOA
involved in negative regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
19446321 GOA
involved in positive regulation of autophagy IDA
IDA: Inferred from direct assay
22017875 GOA
involved in regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
19446321 GOA
Cellular Component GO Annotation Evidence References Source
is active in lysosomal membrane IDA
IDA: Inferred from direct assay
25936805 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DEPTOR Protein Structure

DEP

DEP: Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) (50 - 117)

DEP

DEP: Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) (151 - 217)

  • 0
  • 100
  • 200
  • 300
  • 409 a.a.
Protein Preferred Names Protein Names

DEP domain-containing mTOR-interacting protein

  • DEP domain containing 6

DEPTOR Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DEPTOR Q8TB45 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
Intra
DEPTOR Q8TB45 ANKRD11 Homo sapiens X5D778
Y2H Array
32296183
Intra
DEPTOR Q8TB45 ANKRD11 Homo sapiens X5D778
Y2H Prey Pooling
32296183
Intra
DEPTOR Q8TB45 CCDC110 Homo sapiens Q8TBZ0
Y2H Prey Pooling
25416956
Intra
DEPTOR Q8TB45 CCDC110 Homo sapiens Q8TBZ0
Validated Y2H
25416956
Intra
DEPTOR Q8TB45 CCDC110 Homo sapiens Q8TBZ0
Y2H Array
25416956
Intra
DEPTOR Q8TB45 TRAF1 Homo sapiens Q13077
Y2H Array
25416956
Intra
DEPTOR Q8TB45 MTOR Homo sapiens P42345
Anti Bait CoIP
19446321
Intra
DEPTOR Q8TB45 MTOR Homo sapiens P42345
Anti Tag CoIP
19446321
Cross
DEPTOR Q8TB45 Mtor Rattus norvegicus P42346
Anti Tag CoIP
19446321
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Subependymal Glioma

  • Mixed Subependymoma-Ependymoma

  • Subependymal Astrocytoma

  • Who Grade I Ependymal Tumor

  • Glioma, Subependymal
Neurodegeneration With Brain Iron Accumulation

  • Nbia

  • Neurodegeneration With Brain Iron Accumulation Disorders

  • Neurodegeneration, With Brain Iron Accumulation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-132902 DEPTOR-IN-1 Inhibitor 98.13% Unkown
HY-RS03697 DEPTOR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-164385 NSC126405 Inhibitor 99.20% Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DEPTOR VGNC VGNC:28008
Mus musculus DEPTOR MGD MGI:2146322
Macaca mulatta DEPTOR VGNC VGNC:71691
Canis familiaris DEPTOR VGNC VGNC:39900
Felis catus DEPTOR VGNC VGNC:61446
Rattus norvegicus DEPTOR RGD RGD:1561030
Others DEPTOR NCBI