Atp5f1a - ATP synthase F1 subunit alpha Gene

Enables ADP binding activity; ATP binding activity; and protease binding activity. Contributes to ATP hydrolysis activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to nitric oxide; and response to muscle activity. Located in several cellular components, including cell surface; membrane raft; and mitochondrial inner membrane. Part of mitochondrial proton-transporting ATP Synthase complex, catalytic sector F(1). Used to study non-alcoholic fatty liver disease and pulmonary hypertension. Biomarker of Alzheimer's disease and hypertension. Human ortholog(s) of this gene implicated in combined Oxidative Phosphorylation deficiency 22 and mitochondrial complex V (ATP Synthase) deficiency nuclear type 4. Orthologous to human ATP5F1A (ATP Synthase F1 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]