Tab1 - TGF-beta activated kinase 1/MAP3K7 binding protein 1 Gene

Also Known as Map3k7ip1; b2b449Clo; 2310012M03Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66513

Summary

Enables kinase activator activity. Acts upstream of or within several processes, including circulatory system development; positive regulation of MAPK cascade; and transforming growth factor beta receptor signaling pathway. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and nucleus. Is expressed in genitourinary system. Orthologous to human TAB1 (TGF-beta activated kinase 1 (MAP3K7) binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Tab1 Products (1)

mRNA Protein Name
NM_025609.3 NP_079885.2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables kinase activator activity IMP
IMP: Inferred from mutant phenotype
12464436 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17709393 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within cardiac septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within heart morphogenesis IMP
IMP: Inferred from mutant phenotype
12464436 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
12464436 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
12464436 MGI
acts upstream of or within positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
12464436 MGI
acts upstream of or within transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
12464436 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

  • Tak1-binding protein 1

  • mitogen-activated protein kinase kinase kinase 7-interacting protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2435 [8]-Shogaol 99.93% Unkown
HY-114454 INH14 Inhibitor 98.0% Unkown
HY-167704 NF023 / Unkown
HY-RS14133 TAB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19961 Tab1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26463 Tab1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tab1 NCBI NCBI:10454