Vps28 - vacuolar protein sorting 28 Gene

Also Known as CIIA; 1110014J03Rik; D730005C08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66914

Summary

This gene encodes a protein which is thought to be a subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of enveloped viruses from the cell membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

Vps28 Products (2)

mRNA Protein Name
NM_001305668.1 NP_001292597.1 vacuolar protein sorting-associated protein 28 homolog isoform 2
NM_025842.4 NP_080118.1 vacuolar protein sorting-associated protein 28 homolog isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14557248 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vacuolar protein sorting-associated protein 28 homolog

  • ESCRT-I complex subunit VPS28

  • caspase-activated DNase inhibitor that interacts with ASK1

Vps28 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Vps28 Q9D1C8 MAP3K5 Homo sapiens Q99683
Confocal
14557248
Cross
Vps28 Q9D1C8 MAP3K5 Homo sapiens Q99683
Pull Down
14557248
Intra
Vps28 Q9D1C8 Dffb Mus musculus O54788
Anti Bait CoIP
14557248
Intra
Vps28 Q9D1C8 Dffb Mus musculus O54788
Pull Down
14557248
Intra
Vps28 Q9D1C8 Dffb Mus musculus O54788
Confocal
14557248
Intra
Vps28 Q9D1C8 Map3k5 Mus musculus O35099
Anti Bait CoIP
14557248
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15681 VPS28 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vps28 NCBI NCBI:51160