BST2 - bone marrow stromal cell antigen 2 Gene

Also Known as CD317; HM1.24; TETHERIN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 684

About BST2

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,402,939-17,405,630 (from NCBI)

This gene has 3 transcripts (splice variants) and 83 orthologues. Broad expression in ovary (RPKM 235.4), adrenal (RPKM 135.4) and 22 other tissues.

Summary

Bone marrow stromal cells are involved in the growth and development of B-cells. The specific function of the protein encoded by the bone marrow stromal cell antigen 2 is undetermined; however, this protein may play a role in pre-B-cell growth and in rheumatoid arthritis. [provided by RefSeq, Jul 2008]

BST2 Products (1)

mRNA	Protein	Name
NM_004335.4	NP_004326.1	bone marrow stromal antigen 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	19879838	GOA
enables metalloendopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	22065321	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19179289	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	20399176	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in defense response to virus	IDA IDA: Inferred from direct assay	20399176	GOA
involved in innate immune response	IDA IDA: Inferred from direct assay	19036818	GOA
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	22065321	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	22065321	GOA
involved in negative regulation of intracellular transport of viral material	IDA IDA: Inferred from direct assay	19036818	GOA
involved in negative regulation of plasmacytoid dendritic cell cytokine production	IDA IDA: Inferred from direct assay	19564354	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	20943977	GOA
involved in response to virus	IDA IDA: Inferred from direct assay	19036818	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IMP IMP: Inferred from mutant phenotype	22072966	GOA
colocalizes with cytoplasm	IDA IDA: Inferred from direct assay	22065321	GOA
located in multivesicular body	IMP IMP: Inferred from mutant phenotype	22072966	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19036818	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
bone marrow stromal antigen 2	BST-2

BST2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	BST2	Q10589	Ap1m1	Mus musculus	P35585	GMS	24843023
Cross	BST2	Q10589	GP	Zaire ebolavirus	A9QPL9	Anti Bait CoIP	19179289
Cross	BST2	Q10589	GP	Zaire ebolavirus	A9QPL9	Anti Tag CoIP	19179289
Intra	BST2	Q10589	BST2	Homo sapiens	Q10589	X-Ray Diffraction	20880831
Intra	BST2	Q10589	BST2	Homo sapiens	Q10589	TEM	20940320
Intra	BST2	Q10589	BST2	Homo sapiens	Q10589	Light Scattering	20940320
Intra	BST2	Q10589	BST2	Homo sapiens	Q10589	X-Ray Diffraction	20940320
Intra	BST2	Q10589	BST2	Homo sapiens	Q10589	Solution Sedimentation	20880831
Intra	BST2	Q10589	BST2	Homo sapiens	Q10589	SLCA	20880831
Intra	BST2	Q10589	BST2	Homo sapiens	Q10589	GMS	20940320
Intra	BST2	Q10589	BST2	Homo sapiens	Q10589	Comigration in SDS	20940320
Intra	BST2	Q10589	BST2	Homo sapiens	Q10589	Comigration in Gel	19879838
Intra	BST2	Q10589	vpu	Human immunodeficiency virus	P69699	Solution NMR	22072710
Intra	BST2	Q10589	vpu	Human immunodeficiency virus	P69699	Solid State NMR	22072710

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BST2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7673	BST2 Protein, Human (HEK293, His)	Q10589 (N49-S161)	≥ 95%, as determined by reducing SDS-PAGE.

BST2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83612	BST2 Antibody (YA3357)	WB, IHC-P, FC	Human

Related Diseases

Diseases	Alias
Stomatitis
Human Immunodeficiency Virus Type 1	Aids Hiv/Aids Aids, Delayed/Rapid Progression To Hiv-1, Susceptibility To Hiv-1 Viremia, Susceptibility To Human Immunodeficiency Virus Type 1, Susceptibility To Hiv-1 Aids, Slow Progression To Rapid Progression To Aids From Hiv1 Infection Hiv1 Infection, Resistance To Hiv1 Infection Hiv-1 Viremia Aids, Resistance To Aids, Rapid Progression To Hiv/Aids, Susceptibility To Hiv-1, Resistance To Hiv1, Resistance To Hiv1 Hiv-1 Disease, Delayed Progression Of Hiv-1 Disease, Rapid Progression Of Hiv Infection, Resistance To Hiv Type 1, Susceptibility To Hiv Type 1 Hiv-1 Infection Human Immunodeficiency Virus I Infection Acquired Immunodeficiency Syndrome Hiv-Infection/Aids
Colorado Tick Fever	Mountain Tick Fever Tick Fever, American Mountain American Mountain Fever Colorado Tick Encephalitis Colorado Tick-Borne Disease Mountain Fever American Mountain Tick Fever Colorado Tick-Borne Fever Colorado Tick Fever Virus Non-Exanthematous Tick Fever
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Human T-Cell Leukemia Virus Type 1	Htlv-1 Human T Lymphotropic Virus Type 1
Ebola Hemorrhagic Fever	Ebola Virus Disease Viral Hemorrhagic Fever Hemorrhagic Fever, Ebola Ebola Ehf Ebola Fever Hemorrhagic Fevers, Viral Ebola Haemorrhagic Fever Ebod - [Ebola Disease] Evd - [Ebola Virus Disease] Ebola Virus Haemorrhagic Fever Vhf - [Viral Haemorrhagic Fever] Nos Viral Haemorrhagic Fever, Not Otherwise Specified
Lassa Fever	Lf Lassa Hemorrhagic Fever Lf - [Lassa Fever]
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125900	Neocarzilin A		95.82%	Unkown
HY-RS01649	BST2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17448	Bst2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23904	Bst2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990276	Anti-Mouse CD317/BST2 Antibody (927)	Inhibitor	≥95.0%	Unkown
HY-P991885	Anti-CD317 Antibody (HM1.24 )		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BST2	MGD	MGI:1916800
Canis familiaris	BST2	VGNC	VGNC:38542
Macaca mulatta	BST2	VGNC	VGNC:70286
Rattus norvegicus	BST2	RGD	RGD:727849
Felis catus	BST2	VGNC	VGNC:102008
Others	BST2	NCBI