Ryr2 - ryanodine receptor 2 Gene

Also Known as RyR; RYR-2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 689560

Summary

Enables calcium-induced calcium release activity; ryanodine-sensitive calcium-release channel activity; and scaffold protein binding activity. Involved in several processes, including metal ion transport; negative regulation of cytosolic calcium ion concentration; and response to magnesium ion. Located in several cellular components, including A band; sarcolemma; and sarcoplasmic reticulum membrane. Is extrinsic component of cytoplasmic side of plasma membrane. Part of protein-containing complex. Colocalizes with Z disc. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 2; and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ryr2 Products (2)

mRNA	Protein	Name
NM_001191043.3	NP_001177972.2	ryanodine receptor 2 isoform 2
NM_032078.3	NP_114467.2	ryanodine receptor 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium-induced calcium release activity	IDA IDA: Inferred from direct assay	18799678	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15010472	RGD
enables ryanodine-sensitive calcium-release channel activity	IDA IDA: Inferred from direct assay	18799678	RGD
enables ryanodine-sensitive calcium-release channel activity	IMP IMP: Inferred from mutant phenotype	21807619	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	11590243	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	19116207	RGD
involved in manganese ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	19116207	RGD
involved in monoatomic ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	19116207	RGD
involved in negative regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	18799678	RGD
involved in regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	15870112	RGD
involved in response to calcium ion	IDA IDA: Inferred from direct assay	17027851	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	22962011	RGD
involved in response to magnesium ion	IDA IDA: Inferred from direct assay	16971497	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	17224993	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	15916736	RGD
involved in sarcoplasmic reticulum calcium ion transport	IMP IMP: Inferred from mutant phenotype	21807619	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in A band	IDA IDA: Inferred from direct assay	17627991	RGD
located in Z disc	IDA IDA: Inferred from direct assay	11053140	RGD
located in extrinsic component of cytoplasmic side of plasma membrane	IDA IDA: Inferred from direct assay	20177054	RGD
located in nuclear envelope	IDA IDA: Inferred from direct assay	11590243	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	16306226	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	21474431	RGD
located in sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	11590243	RGD
located in sarcoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	11053140	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ryanodine receptor 2	cardiac muscle ryanodine receptor cardiac muscle ryanodine receptor-calcium release channel cardiac-type ryaodine receptor ryanodine receptor 2, cardiac ryanodine receptor type II type 2 ryanodine receptor

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W010950	Flecainide	Inhibitor	99.98%	Unkown
HY-W010950A	Flecainide hydrochloride	Inhibitor	99.93%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-119850	Aladorian	Modulator	99.55%	Phase 2

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149662	TMDJ-035	Inhibitor	99.92%	Unkown
HY-15292	S107	Ligand	99.77%	Unkown
HY-N7491A	Ent-(+)-Verticilide	Inhibitor	99.91%	Unkown
HY-P5114A	Maurocalcine TFA	Agonist	95.09%	Unkown
HY-RS12369	RYR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-103059	SOICR-IN-1		99.62%	Unkown
HY-P5114	Maurocalcine	Agonist	/	Unkown
HY-Z7733	O-Desmethylcarvedilol	Inhibitor	97.4%	Unkown
HY-119850A	Aladorian sodium	Modulator	/	Unkown
HY-178344	Multi-target kinase-IN-6	Activator	/	Unkown
HY-P5319	MCaE12A	Activator	/	Unkown
HY-149779	RyR2 stabilizer-1	Modulator	/	Unkown
HY-164631	EL20	Inhibitor	/	Unkown
HY-166478S	O-Desmethyl carvedilol-d5	Inhibitor	/	Unkown
HY-RS19951	Ryr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26453	Ryr2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W010950S	Flecainide-d3		99.9%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ryr2	NCBI	NCBI:6262