Fbxo7 - F-box protein 7 Gene

Also Known as 2410015K21Rik; A230052G17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 69754

Summary

Enables protein kinase binding activity. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cyclin-dependent protein serine/threonine kinase activity; and negative regulation of lymphocyte differentiation. Located in mitochondrion and nucleus. Is expressed in dorsal root ganglion; gallbladder; liver; trigeminal ganglion; and vagus ganglion. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 15. Orthologous to human FBXO7 (F-box protein 7). [provided by Alliance of Genome Resources, Apr 2022]

Fbxo7 Products (3)

mRNA Protein Name
NM_001310745.1 NP_001297674.1 F-box only protein 7 isoform 2
NM_001347151.1 NP_001334080.1 F-box only protein 7 isoform 3
NM_153195.2 NP_694875.2 F-box only protein 7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21652635 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of lymphocyte differentiation IGI
IGI: Inferred from genetic interaction
21652635 MGI
acts upstream of lymphocyte differentiation IMP
IMP: Inferred from mutant phenotype
21652635 MGI
acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
21652635 MGI
acts upstream of or within negative regulation of cyclin-dependent protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
21652635 MGI
acts upstream of or within negative regulation of lymphocyte differentiation IGI
IGI: Inferred from genetic interaction
21652635 MGI
acts upstream of or within negative regulation of lymphocyte differentiation IMP
IMP: Inferred from mutant phenotype
21652635 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
26310625 MGI
located in nucleus IDA
IDA: Inferred from direct assay
26310625 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-box only protein 7

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-162240 SJH1-51B Degrader / Unkown
HY-RS04813 FBXO7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22503 Fbxo7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29025 Fbxo7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fbxo7 NCBI NCBI:25793