THOP1 - thimet oligopeptidase 1 Gene

Also Known as TOP; MP78; EP24.15; MEPD_HUMAN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7064

About THOP1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:2,785,503-2,815,807 (from NCBI)

This gene has 14 transcripts (splice variants), 205 orthologues and 2 paralogues. Broad expression in testis (RPKM 14.1), brain (RPKM 6.4) and 24 other tissues.

Summary

The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]

THOP1 Products (1)

mRNA Protein Name
NM_003249.5 NP_003240.1 thimet oligopeptidase

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19614740 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THOP1 Protein Structure

Peptidase_M3

Peptidase_M3: Peptidase family M3 (227 - 675)

  • 0
  • 200
  • 400
  • 600
  • 689 a.a.
Protein Preferred Names Protein Names

thimet oligopeptidase

  • endopeptidase 24.15

THOP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
THOP1 P52888 EPN2 Homo sapiens O95208-2
Y2H Prey Pooling
32296183
Intra
THOP1 P52888 EPN2 Homo sapiens O95208-2
Y2H Array
32296183
Intra
THOP1 P52888 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Intra
THOP1 P52888 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
Intra
THOP1 P52888 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Cross
THOP1 P52888 Calm1 Rattus norvegicus P0DP29
SPR
19614740
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant THOP1 Proteins

Cat. No. Product Name Accession Purity
HY-P71359 THOP1 Protein, Human (His) P52888 (K2-C689) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Methemoglobinemia And Ambiguous Genitalia

  • METAG

  • Methemoglobinemia Type Iv

  • Isolated 17,20-Lyase Deficiency, Pure

  • Methemoglobinemia Due To Deficiency Of Cytochrome B5

  • Methemoglobinemia Type 4

  • Methemoglobinemia Type Iv, Formerly

  • Methemoglobinemia Due To Deficiency Of Cytochrome B5, Formerly

  • Pure Isolated 17,20-Lyase Deficiency

  • Methemoglobinemia, Type Iv
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14497 THOP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19241 Thop1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25730 Thop1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris THOP1 VGNC VGNC:47353
Felis catus THOP1 VGNC VGNC:66170
Macaca mulatta THOP1 VGNC VGNC:78347
Bos taurus THOP1 VGNC VGNC:35843
Mus musculus THOP1 MGD MGI:1354165
Rattus norvegicus THOP1 RGD RGD:68330
Others THOP1 NCBI