TLR5 - toll like receptor 5 Gene

Also Known as SLE1; TIL3; SLEB1; MELIOS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7100

About TLR5

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:223,109,404-223,143,248 (from NCBI)

This gene has 8 transcripts (splice variants), 183 orthologues, 22 paralogues and is associated with 3 phenotypes. Ubiquitous expression in ovary (RPKM 7.6), lung (RPKM 2.6) and 22 other tissues.

Summary

This gene encodes a member of the Toll-like Receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes Bacterial flagellin, the principal component of Bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]

TLR5 Products (1)

mRNA	Protein	Name
NM_003268.6	NP_003259.2	toll-like receptor 5 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables interleukin-1 receptor binding	IPI IPI: Inferred from physical interaction	12925853	GOA
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	14625549	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	30158114	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
acts upstream of positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	17128265	GOA
involved in toll-like receptor 5 signaling pathway	IDA IDA: Inferred from direct assay	14625549	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	24778236	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TLR5 Protein Structure

LRR_8

LRR_1

LRR_8

TIR

0
200
400
600
800
858 a.a.

Protein Preferred Names	Protein Names
toll-like receptor 5	systemic lupus erythematosus susceptibility 1

TLR5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TLR5	O60602	P05067-PRO_0000000093	Homo sapiens	P05067-PRO_0000000093	BLI	30158114
Intra	TLR5	O60602	P05067-PRO_0000000093	Homo sapiens	P05067-PRO_0000000093	ELISA	30158114
Intra	TLR5	O60602	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	ELISA	30158114
Intra	TLR5	O60602	P05067-PRO_0000000092	Homo sapiens	P05067-PRO_0000000092	BLI	30158114

Cross: Cross-species interaction Intra: Intraspecies interaction

TLR5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810775	Toll-like receptor 5 Antibody (YA10018)	WB, ICC/IF	Human, Mouse, Rat
HY-P83520	Toll-Like Receptor 5 Antibody (YA3265)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Legionnaire Disease	Legionnaires' Disease Legionnaires Disease Legionnaire Disease, Susceptibility To Legionella Legionella Pneumonia Infection By Legionella Pneumophilia Legionnaire'S Disease Legionellosis Legionaire Disease, Susceptibility To Legionnaires Pneumonia
Melioidosis	Melioidosis, Susceptibility To Acute And Fulminating Melioidosis Nightcliff Gardener'S Disease Pseudoglanders Subacute And Chronic Melioidosis Burkholderia Pseudomallei Infection Whitmore Disease Whitmore'S Disease B Pseudomallei Infection Epizootic Lymphangitis Infection Due To Burkholderia Pseudomallei Infection Due To Burkholderia Pseudomallei Nos Infection Due To Malleomyces Pseudomallei Infection Due To Pseudomonas Pseudomallei Infection Due To Pseudomonas Pseudomallei Nos Infection Due To Whitmore Bacillus Stanton Disease
Systemic Lupus Erythematosus 1	SLEB1 Systemic Lupus Erythematosus, Susceptibility To, 1 Systemic Lupus Erythematosus, Resistance To Systemic Lupus Erythematosus Lupus Erythematosus, Systemic, Type 1 Lupus Erythematosus, Systemic
Lupus Erythematosus	Lupus Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus, Systemic Subacute Cutaneous Lupus Le - [Lupus Erythematosus]
Typhoid Fever	Typhoid Enteric Fever Typhoidal Salmonellosis Ileotyphus Infection By Salmonella Typhi Typhoid Any Site Typhoid Fever Any Site Typhoid Infection Typhoid Infection Any Site Typhoid Fever Confirmed Enteric Fever Nos
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Bacteriuria
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Ileitis	Crohn'S Ileitis
Legionellosis	Legionella Infection Pontiac Fever Legionnaires' Disease Infection By Legionella Pneumophilia Legionella Pneumophila Infection
Colitis
Toxoplasmosis	Disseminated Toxoplasmosis Multisystemic Disseminated Toxoplasmosis Acquired Toxoplasmosis Toxoplasmosis Disease Or Disorder Infection By Toxoplasma Gondii Toxoplasmal Toxoplasma
Aspergillosis	Aspergillosis, Susceptibility To Infection Due To Aspergillus Aspergilloma Aspergillus Nodule Simple Aspergilloma Aspergillus Aspergillus Flavus Infection Aspergillus Fumigatus Infection Aspergillus Infection Infection By Aspergillus Fumigatus Intracavitary Aspergillus Fungus Ball Aspergillus Terreus
Bacterial Infectious Disease	Bacterial Infections Bacterial Infection Nos Disease Caused By Bacteria Bacterial Disease Or Disorder
Salmonellosis	Salmonella Infections Salmonella Infection
Otitis Media	Opsoclonus-Myoclonus Syndrome OMS Otitis Media, Susceptibility To Kinsbourne Syndrome Otitis Media, Chronic/Recurrent Come/Rom Ataxo-Opso-Myoclonus Syndrome Dancing Eye Syndrome Dancing Eye-Dancing Feet Syndrome Oma Syndrome Opsoclonus Myoclonus Syndrome Opsoclonus-Myoclonus-Ataxia Syndrome Poma Syndrome Paraneoplastic Opsoclonus-Myoclonus Paraneoplastic Opsoclonus-Myoclonus-Ataxia Syndrome Opsoclonus Myoclonus OM {Otitis Media, Susceptibility To} Infectious Otitis Media
Superficial Basal Cell Carcinoma	Multifocal Superficial Basal Cell Carcinoma Multicentric Basal Cell Carcinoma Superficial Multicentric Basal-Cell Carcinoma
Von Willebrand Disease, Type 3	Von Willebrand Disease Type 3 VWD3 Von Willebrand'S Disease 3 Von Willebrand Disease Type Iii Von Willebrand Disease, Type Iii Vwd, Type 3 Vwd Type 3 Von Willebrand Disease 3 Von Willebrand Disease Recessive Form Von Willebrand Factor Deficiency Type 3
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Chromosome 17q23.1-Q23.2 Deletion Syndrome	17q23.1q23.2 Microdeletion Syndrome 17q23.1-Q23.2 Microdeletion Syndrome Del(17)(Q23.1q23.2) Monosomy 17q23.1q23.2 Monosomy 17q23.1-Q23.2
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos
Pneumonic Tularemia	Pulmonary Tularemia Bronchopneumonic Tularemia Pneumonic Tularaemia
Glanders	Farcy Pipes Infection Due To Pseudomonas Mallei Burkholderia Mallei Burkholderia Mallei Infection Equina Equine Glanders Farcy Farcy Buds Farcy Cords Infection Due To Actinobacillus Mallei Infection Due To Malleomyces Mallei Maliasmus Malleus Farce Actinobacillosis Actinobacillus Infection
Primary Bacterial Infectious Disease
Anogenital Venereal Wart	Genital Warts Condylomata Acuminata Anogenital Warts Condyloma Acuminatum Anogenital Human Papilloma Virus Infectious Disease Genital Wart Virus Infectious Disease Venereal Wart Venereal Warts Verrucae Anogenitales Verrucae Genitales
Blood Group, Globoside System	Globe Disease GLOB Blood Group System, Globoside
Perinatal Necrotizing Enterocolitis	Necrotizing Enterocolitis Enterocolitis Necrotizing Enterocolitis, Necrotizing Necrotizing Enterocolitis In Fetus Or Newborn Perinatal Necrotising Enterocolitis Pseudomembranous Enterocolitis In Newborn Nec
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Plague	Yersiniosis Yersinia Infections Infection By Yersinia Pestis Pasteurella Pestis Infection Pestilential Fever Yersinia Pestis Infection
Cataract 9, Multiple Types	Cataract 9 Multiple Types CTRCT9 Cataract, Autosomal Dominant Catc1 Cataract 9, Multiple Types, With Or Without Microcornea Cataract, Autosomal Recessive Congenital 1 Autosomal Recessive Congenital Cataract 1 Cataract 9 Multiple Types With Or Without Microcornea Autosomal Dominant Congenital Cataract Cataract Autosomal Dominant Cataracts, Autosomal Dominant
Ankylosing Spondylitis 1	Ankylosing Spondylitis, Susceptibility To, 1
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Crohn'S Disease	Crohn Disease Pediatric Crohn'S Disease Regional Enteritis Crohn'S Disease Of Large Bowel Granulomatous Colitis Enteritis, Granulomatous Enteritis Crohn'S Disease Of Colon Colitis, Granulomatous Crohn'S Enteritis Enteritis, Regional Ileitis Adenoviral Enteritis Acute Gastroenteropathy Due To Norwalk Agent Viral Gastroenteritis Due To Norwalk Agent Winter Vomiting Epidemic Winter Vomiting Disease Small Round Structured Virus Enteritis Epidemic Vomiting Syndrome Epidemic Vomiting Epidemic Nausea Epidemic Viral Gastroenteritis Due To Norwalk Virus Noroviral Enteritis Crohn Disease Nos Crohns Cd - [Crohn'S Disease] Regional Enteritis Of Bowel Crohn'S Regional Enteritis Cobble-Stone Appearance Of Intestine Intestinal Ulcer And Erosion Due To Crohn Disease Granulomatous Enteritis
Celiac Disease 1	Celiac Disease Coeliac Disease Celiac Sprue Celiac Disease, Susceptibility To Gluten-Sensitive Enteropathy Nontropical Sprue Sprue CELIAC1 Celiac Disease, Susceptibility To, 1 Celiac Sprue 1 Celiac Sprue, Susceptibility To, 1 Gluten-Sensitive Enteropathy 1 Gluten-Sensitive Enteropathy, Susceptibility To, 1 Idiopathic Steatorrhea Cœliac Disease Gluten Intolerance Gluten-Induced Enteropathy Gluten Enteropathy Celiac Disease, Susceptibility To, Type 1 Childhood Celiac Disease Coeliac Rickets Gee Disease Gee-Herter Disease Heubner-Herter Disease Idiopathic Steatorrhoea Thaysen'S Disease Herter Gee Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-178166	ETI41	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116961	TH1020		99.81%	Unkown
HY-N15135	Arabinoxylan (Medium viscosity)		95.0%	Unkown
HY-106801	Girolline		/	Unkown
HY-NP134	Flagellin from S. typhimurium		95%	Unkown
HY-178169	ETI60	Inhibitor	99.51%	Unkown
HY-RS14589	TLR5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174313	Antibacterial agent 284	Inhibitor	/	Unkown
HY-174523	Human TLR5 mRNA		/	Unkown
HY-RS16808	Tlr5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23248	Tlr5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TLR5	RGD	RGD:631351
Bos taurus	TLR5	VGNC	VGNC:52835
Mus musculus	TLR5	MGD	MGI:1858171
Macaca mulatta	TLR5	VGNC	VGNC:78376
Felis catus	TLR5	VGNC	VGNC:107950
Others	TLR5	NCBI