TPD52 - tumor protein D52 Gene

Also Known as D52; N8L; PC-1; PrLZ; hD52

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7163

About TPD52

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:80,031,082-80,171,564 (from NCBI)

This gene has 29 transcripts (splice variants), 217 orthologues and 3 paralogues. Broad expression in colon (RPKM 43.8), prostate (RPKM 36.3) and 23 other tissues.

Summary

Enables calcium ion binding activity and protein homodimerization activity. Involved in B cell differentiation. Located in endoplasmic reticulum and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TPD52 Products (9)

mRNA Protein Name
NM_001025252.3 NP_001020423.1 tumor protein D52 isoform 1
NM_001025253.3 NP_001020424.1 tumor protein D52 isoform 2
NM_001287140.2 NP_001274069.1 tumor protein D52 isoform 4
NM_001287142.2 NP_001274071.1 tumor protein D52 isoform 5
NM_001287143.2 NP_001274072.1 tumor protein D52 isoform 6
NM_001287144.2 NP_001274073.1 tumor protein D52 isoform 7
NM_001387779.1 NP_001374708.1 tumor protein D52 isoform 9
NM_001387780.1 NP_001374709.1 tumor protein D52 isoform 10
NM_005079.4 NP_005070.1 tumor protein D52 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
15576473 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9484778 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
9484778 GOA
Biological Process GO Annotation Evidence References Source
involved in B cell differentiation IEP
IEP: Inferred from expression pattern
15576473 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15576473 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
10942595 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16112108 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPD52 Protein Structure

TPD52

TPD52: Tumour protein D52 family (47 - 211)

  • 0
  • 100
  • 200
  • 224 a.a.
Protein Preferred Names Protein Names

tumor protein D52

  • prostate and colon associated protein

TPD52 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TPD52 P55327 TPD52L1 Homo sapiens Q16890
Y2H
9484778
Intra
TPD52 P55327 TPD52L1 Homo sapiens Q16890
Anti Tag CoIP
33961781
Cross
TPD52 P55327 Tpd52 Mus musculus Q62393
Pull Down
9484778
Cross
TPD52 P55327 Tpd52 Mus musculus Q62393
Y2H
9484778
Cross: Cross-species interaction Intra: Intraspecies interaction

TPD52 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89748 TPD52 Antibody (YA9092) WB, ICC/IF, IF-Tissue, IP, ELISA human

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Non-Syndromic X-Linked Intellectual Disability 21

  • Mrx21

  • Mrx34

  • X-Linked Mental Retardation 21

  • X-Linked Mental Retardation 34
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14928 TPD52 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14929 TPD52L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14930 TPD52L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21792 Tpd52 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TPD52 VGNC VGNC:84130
Rattus norvegicus TPD52 RGD RGD:1306767
Mus musculus TPD52 MGD MGI:107749
Others TPD52 NCBI