TPD52L1 - TPD52 like 1 Gene

Also Known as D53; TPD53

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7164

About TPD52L1

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:125,153,773-125,264,407 (from NCBI)

This gene has 17 transcripts (splice variants), 202 orthologues and 3 paralogues. Broad expression in adrenal (RPKM 40.8), salivary gland (RPKM 18.6) and 14 other tissues.

Summary

This gene encodes a member of a family of proteins that contain coiled-coil domains and may form hetero- or homomers. The encoded protein is involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced Apoptosis. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2016]

TPD52L1 Products (8)

mRNA Protein Name
NM_001003395.3 NP_001003395.1 tumor protein D53 isoform 2
NM_001003396.3 NP_001003396.1 tumor protein D53 isoform 3
NM_001003397.3 NP_001003397.1 tumor protein D53 isoform 4
NM_001292026.3 NP_001278955.1 tumor protein D53 isoform 5
NM_001300994.3 NP_001287923.1 tumor protein D53 isoform 6
NM_001318903.2 NP_001305832.1 tumor protein D53 isoform 7
NM_001318907.2 NP_001305836.1 tumor protein D53 isoform 5
NM_003287.4 NP_003278.1 tumor protein D53 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
9484778 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9484778 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
9484778 GOA
Biological Process GO Annotation Evidence References Source
involved in G2/M transition of mitotic cell cycle IDA
IDA: Inferred from direct assay
16112108 GOA
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
14761963 GOA
involved in positive regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
14761963 GOA
involved in positive regulation of apoptotic signaling pathway IDA
IDA: Inferred from direct assay
14761963 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12963375 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12963375 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPD52L1 Protein Structure

TPD52

TPD52: Tumour protein D52 family (7 - 188)

  • 0
  • 100
  • 204 a.a.
Protein Preferred Names Protein Names

tumor protein D53

  • tumor protein D52 like 1

TPD52L1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TPD52L1 Q16890 TPD52 Homo sapiens P55327
Anti Tag CoIP
33961781
Intra
TPD52L1 Q16890 YWHAB Homo sapiens P31946
Pull Down
12963375
Intra
TPD52L1 Q16890 YWHAB Homo sapiens P31946
Y2H
12963375
Intra
TPD52L1 Q16890 TPD52 Homo sapiens P55327
Y2H
9484778
Intra
TPD52L1 Q16890 YWHAZ Homo sapiens P63104
CoIP
12963375
Intra
TPD52L1 Q16890 TPD52L3 Homo sapiens Q96J77
Y2H
16631610
Intra
TPD52L1 Q16890 PAK6 Homo sapiens Q9NQU5
Y2H Array
21988832
Cross
TPD52L1 Q16890 Tpd52 Mus musculus Q62393
Y2H
9484778
Intra
TPD52L1 Q16890 YWHAB Homo sapiens P31946
CoIP
12963375
Intra
TPD52L1 Q16890 EIF3J Homo sapiens O75822
Y2H Pooling
16169070
Intra
TPD52L1 Q16890 YWHAZ Homo sapiens P63104
Pull Down
12963375
Intra
TPD52L1 Q16890 DAPK1 Homo sapiens P53355
Protein Array
29513927
Intra
TPD52L1 Q16890 YWHAZ Homo sapiens P63104
Y2H
12963375
Cross: Cross-species interaction Intra: Intraspecies interaction

TPD52L1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89964 D53 Antibody (YA9308) WB, ICC/IF, IF-Tissue, IHC-P human

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14929 TPD52L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TPD52L1 MGD MGI:1298386
Macaca mulatta TPD52L1 VGNC VGNC:78632
Felis catus TPD52L1 VGNC VGNC:66471
Canis familiaris TPD52L1 VGNC VGNC:47734
Rattus norvegicus TPD52L1 RGD RGD:1594796
Bos taurus TPD52L1 VGNC VGNC:36245