TPR - translocated promoter region, nuclear basket protein Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7175

About TPR

Cytogenetic location: 1q31.1 Genomic coordinates (GRCh38): 1:186,311,652-186,375,253 (from NCBI)

This gene has 9 transcripts (splice variants), 277 orthologues and is associated with 94 phenotypes. Ubiquitous expression in testis (RPKM 29.9), thyroid (RPKM 16.2) and 25 other tissues.

Summary

This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]

TPR Products (1)

mRNA	Protein	Name
NM_003292.3	NP_003283.2	nucleoprotein TPR

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	17897941	GOA
enables dynein complex binding	IDA IDA: Inferred from direct assay	20133940	GOA
enables heat shock protein binding	IDA IDA: Inferred from direct assay	17897941	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	17897941	GOA
enables mitogen-activated protein kinase binding	IDA IDA: Inferred from direct assay	18794356	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12802065	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	11514627	GOA
NOT enables protein-membrane adaptor activity	IMP IMP: Inferred from mutant phenotype	12802065	GOA
enables structural constituent of nuclear pore	IDA IDA: Inferred from direct assay	22253824	GOA
enables tubulin binding	IDA IDA: Inferred from direct assay	20133940	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in RNA export from nucleus	IMP IMP: Inferred from mutant phenotype	11952838	GOA
involved in RNA import into nucleus	IDA IDA: Inferred from direct assay	9864356	GOA
involved in cellular response to heat	IDA IDA: Inferred from direct assay	17897941	GOA
involved in mRNA export from nucleus in response to heat stress	IDA IDA: Inferred from direct assay	17897941	GOA
involved in mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	20133940	GOA
involved in negative regulation of RNA export from nucleus	IDA IDA: Inferred from direct assay	22253824	GOA
involved in negative regulation of RNA export from nucleus	IMP IMP: Inferred from mutant phenotype	21613532	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21613532	GOA
involved in negative regulation of translational initiation	IMP IMP: Inferred from mutant phenotype	21613532	GOA
NOT involved in nuclear matrix organization	IMP IMP: Inferred from mutant phenotype	11952838	GOA
NOT involved in nuclear pore complex assembly	IMP IMP: Inferred from mutant phenotype	12802065	GOA
NOT involved in nuclear pore organization	IMP IMP: Inferred from mutant phenotype	11952838	GOA
involved in nuclear pore organization	IMP IMP: Inferred from mutant phenotype	15229283	GOA
involved in positive regulation of heterochromatin formation	IMP IMP: Inferred from mutant phenotype	20407419	GOA
involved in positive regulation of intracellular protein transport	IMP IMP: Inferred from mutant phenotype	19273613	GOA
involved in positive regulation of mitotic cell cycle spindle assembly checkpoint	IMP IMP: Inferred from mutant phenotype	18981471	GOA
involved in positive regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	18794356	GOA
NOT involved in protein export from nucleus	IMP IMP: Inferred from mutant phenotype	11952838	GOA
NOT involved in protein import into nucleus	IDA IDA: Inferred from direct assay	9864356	GOA
NOT involved in protein import into nucleus	IMP IMP: Inferred from mutant phenotype	11952838	GOA
involved in protein import into nucleus	IMP IMP: Inferred from mutant phenotype	18794356	GOA
NOT involved in regulation of mRNA export from nucleus	IMP IMP: Inferred from mutant phenotype	22253824	GOA
involved in regulation of mitotic sister chromatid separation	IMP IMP: Inferred from mutant phenotype	20133940	GOA
involved in regulation of mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	19273613	GOA
NOT involved in regulation of protein export from nucleus	IMP IMP: Inferred from mutant phenotype	22253824	GOA
NOT involved in regulation of protein import into nucleus	IMP IMP: Inferred from mutant phenotype	22253824	GOA
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	18981471	GOA
NOT involved in regulation of protein stability	IMP IMP: Inferred from mutant phenotype	21613532	GOA
involved in response to epidermal growth factor	IDA IDA: Inferred from direct assay	18794356	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11952838	GOA
part of cytoplasmic dynein complex	IDA IDA: Inferred from direct assay	20133940	GOA
NOT located in kinetochore	IDA IDA: Inferred from direct assay	19273613	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	20133940	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	20133940	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	17098863	GOA
located in nuclear inclusion body	IDA IDA: Inferred from direct assay	11514627	GOA
located in nuclear membrane	IDA IDA: Inferred from direct assay	9024684	GOA
located in nuclear periphery	IDA IDA: Inferred from direct assay	9024684	GOA
part of nuclear pore	IDA IDA: Inferred from direct assay	9828100	GOA
part of nuclear pore nuclear basket	IDA IDA: Inferred from direct assay	9024684	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15654337	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TPR Protein Structure

TPR_MLP1_2

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2363 a.a.

Protein Preferred Names	Protein Names
nucleoprotein TPR	NPC-associated intranuclear protein

TPR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TPR	P12270	MAD1L1	Homo sapiens	Q9Y6D9	Pull Down	24581499

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome	Jacobs Syndrome Arthropathy-Camptodactyly Syndrome Pericarditis-Arthropathy-Camptodactyly Syndrome Xyy Syndrome Pac Syndrome Cacp Syndrome CACP Fibrosing Serositis, Familial Camptodactyly-Arthropathy-Pericarditis Syndrome Cap Syndrome 47, Xyy Syndrome 47,Xyy Syndrome Double Y Syndrome Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome Hypertrophic Synovitis, Congenital Familial Congenital Familial Hypertrophic Synovitis Xyy Karyotype Y Disomy Yy Syndrome Familial Fibrosing Serositis Disomy Y Double Y Camptodactyly Arthropathy Coxa Vara Pericarditis Syndrome Arthropathy Camptodactyly Syndrome Camptodactyly Arthropathy Pericarditis Syndrome Pericarditis Arthropathy Camptodactyly Syndrome Jacob'S Syndrome 47,Xyy Cdags Syndrome
Differentiated Thyroid Carcinoma	Papillary Or Follicular Thyroid Carcinoma Well-Differentiated Thyroid Carcinoma Differentiated Thyroid Gland Carcinoma
Bejel	Njovera Dichuchwa Nonvenereal Endemic Syphilis Endemic Syphilis Frenga Nonvenereal Syphilis Treponemal Infections Non-Venereal Endemic Syphilis Siti Skerljevo Belesh
Yaws	Frambesia Frambesia Tropica Bouba Frambosie Polypapilloma Tropicum Thymosis Endemic Treponematoses Treponema Pertenue Infection Pian Framboesia Framboesia Tropica Castellani Infection By Treponema Pertenue Parangi Framboesioma Chancre Of Yaws Primary Framboesia Initial Lesions Of Yaws Mother Yaw Initial Framboesia
Primary Syphilis	Early Symptomatic Syphilis Early Syphilis, Symptomatic Symptomatic Early Syphilis
Secondary Syphilis	Syphilis, Secondary Secondary Syphilis Of Viscera Or Bone
Latent Syphilis	Syphilis, Latent
Late Yaws	Yaws Gummata And Ulcers Gummata And Ulcers Due To Yaws Gummata Of Yaws Gummatous Frambeside Multiple Papillomata Due To Yaws And Wet Crab Yaws Nodular Late Yaws Ulcers Of Yaws
Gummatous Syphilis
Early Yaws	Initial Lesions Of Yaws Bone And Joint Lesions Due To Yaws Bone And Joint Yaws Lesion Chancre Of Yaws Frambesia, Initial Or Primary Initial Frambesial Ulcer Primary Frambesia Initial Lesion Of Yaws
Early Congenital Syphilis
Occipital Lobe Neoplasm	Neoplasm Of Occipital Lobe Malignant Neoplasm Of Occipital Lobe Tumor Of Occipital Lobe
Congenital Syphilis	Syphilis, Congenital Congenital Syphilis, Unspecified Mtct Of Syphilis Mother-To-Child Transmission Of Syphilis Syphilis Congenital Hereditary Syphilis Heredosyphilis
Cardiovascular Syphilis	Syphilis, Cardiovascular
Acute Pericementitis	Acute Periodontitis Aggressive And Acute Periodontitis Peridental Infection Periodontal Infection
Meningovascular Neurosyphilis
Tertiary Syphilis	Late Syphilis Syphilis, Tertiary Late Syphilis, Unspecified Late Tertiary Syphilis
Tertiary Neurosyphilis	Late Neurosyphilis Late Syphilis Of Central Nervous System Nos
Pulp Degeneration	Degeneration Of Dental Pulp
Parenchymatous Neurosyphilis
Syphilis	Chancre Syphilitic Chancre
Familial Renal Papillary Carcinoma	Hereditary Papillary Renal Carcinoma Papillary Renal Cancer Hereditary
Childhood Hepatocellular Carcinoma	Pediatric Hepatocellular Carcinoma Childhood Carcinoma Of Liver Cell Childhood Hepatoma Childhood Liver Cell Carcinoma Pediatric Carcinoma Of Liver Cell Pediatric Hepatoma Pediatric Liver Cell Carcinoma Childhood-Onset Hcc Childhood-Onset Hepatocellular Carcinoma Pediatric Hcc Childhood Liver Cancer
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Renal Cell Carcinoma, Papillary, 1	Papillary Renal Cell Carcinoma Hereditary Papillary Renal Cell Carcinoma Papillary Renal Cell Carcinoma, Sporadic Papillary Renal Cell Adenocarcinoma RCCP RCCP1 Renal Cell Carcinoma, Papillary Renal Cell Carcinoma, Papillary, 1, Familial And Somatic Chromophil Carcinoma Of Kidney Papillary Kidney Carcinoma Sporadic Papillary Renal Cell Carcinoma Chromophil Renal Cell Carcinoma Papillary Renal Carcinoma, Malignant - Papillary Renal Cell Carcinoma, Bilateral - Papillary Renal Cell Carcinoma, Familial - Papillary Renal Cell Carcinoma, Multiple - Papillary Renal Cell Carcinoma, Sporadic - Renal Adenocarcinoma Chromophil Rcc Hprcc Renal Cell Carcinoma Papillary Chromophilic Renal Cell Carcinoma Prcc Carcinoma, Renal Cell, Papillary, Type 1 Type 1 Papillary Renal Cell Carcinoma Renal Cell Carcinoma Hereditary Papillary Renal Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W1128879	XMU-MP-8	Degrader	99.23%	Unkown
HY-103241	Ro 90-7501		98.50%	Unkown
HY-175552	CHIPOpt	Inhibitor	99.49%	Unkown
HY-125759	3-Phenyltoxoflavin	Inhibitor	99.76%	Unkown
HY-P1896	Hsp70-derived octapeptide		98.01%	Unkown
HY-179343	Hsp90-IN-43	Inhibitor	/	Unkown
HY-P11185	Hsp90β decapeptide		/	Unkown
HY-RS14946	TPR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18457	Tpr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24938	Tpr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TPR	VGNC	VGNC:100164
Mus musculus	TPR	MGD	MGI:1922066
Rattus norvegicus	TPR	RGD	RGD:1310664
Felis catus	TPR	VGNC	VGNC:107957
Canis familiaris	TPR	VGNC	VGNC:53807
Others	TPR	NCBI