Adipor1 - adiponectin receptor 1 Gene

Also Known as Paqr1; ACDCR1; CGI-45; 2810031L11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72674

Summary

This gene encodes a receptor for the fat-derived hormone Adiponectin. Binding of Adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and Insulin sensitivity. Homozygous knockout mice for this gene exhibit elevated plasma glucose and Insulin levels as well as impaired glucose tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Adipor1 Products (2)

mRNA Protein Name
NM_001306069.1 NP_001292998.1 adiponectin receptor protein 1
NM_028320.4 NP_082596.2 adiponectin receptor protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables adiponectin binding IPI
IPI: Inferred from physical interaction
12802337 MGI
enables identical protein binding IDA
IDA: Inferred from direct assay
12802337 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12802337 MGI
enables signaling receptor activity IDA
IDA: Inferred from direct assay
12802337 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adiponectin-activated signaling pathway IDA
IDA: Inferred from direct assay
12802337 MGI
involved in adiponectin-activated signaling pathway IMP
IMP: Inferred from mutant phenotype
24742672 MGI
involved in glucose homeostasis IMP
IMP: Inferred from mutant phenotype
24742672 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
24531262 MGI
involved in regulation of glucose metabolic process IMP
IMP: Inferred from mutant phenotype
24742672 MGI
involved in regulation of lipid metabolic process IMP
IMP: Inferred from mutant phenotype
24742672 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
12802337 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adiponectin receptor protein 1

  • progestin and adipoQ receptor family member 1

  • progestin and adipoQ receptor family member I

Adipor1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Adipor1 Q91VH1 APPL1 Homo sapiens Q9UKG1
Y2H
16622416
Cross
Adipor1 Q91VH1 APPL1 Homo sapiens Q9UKG1
Pull Down
16622416
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15848 AdipoRon Agonist 99.88% Unkown
HY-N0166 Gramine 99.80% Unkown
HY-N9182 Zeaxanthin dipalmitate Inducer 99.9% Unkown
HY-110164 AdipoRon hydrochloride Agonist 99.80% Unkown
HY-N0166R Gramine (Standard) 98.95% Unkown
HY-15848R AdipoRon (Standard) Agonist / Unkown
HY-RS00379 ADIPOR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N0166S Gramine-d2 / Unkown
HY-RS21223 Adipor1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27739 Adipor1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adipor1 NCBI NCBI:51094