GTF2H2C - GTF2H2 family member C Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 728340

Summary

Enables RNA polymerase II general transcription initiation factor activity. Involved in G protein-coupled receptor internalization and transcription initiation at RNA polymerase II promoter. Located in nuclear speck. Part of core TFIIH complex portion of holo TFIIH complex and transcription factor TFIID complex. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in testis (RPKM 16.2), thyroid (RPKM 13.7) and 25 other tissues.

GTF2H2C Products (9)

mRNA Protein Name
NM_001098728.3 NP_001092198.1 general transcription factor IIH subunit 2-like protein isoform 1
NM_001375998.1 NP_001362927.1 general transcription factor IIH subunit 2-like protein isoform 1
NM_001375999.1 NP_001362928.1 general transcription factor IIH subunit 2-like protein isoform 1
NM_001376000.2 NP_001362929.1 general transcription factor IIH subunit 2-like protein isoform 1
NM_001376001.1 NP_001362930.1 general transcription factor IIH subunit 2-like protein isoform 1
NM_001376002.1 NP_001362931.1 general transcription factor IIH subunit 2-like protein isoform 2
NM_001376003.1 NP_001362932.1 general transcription factor IIH subunit 2-like protein isoform 3
NM_001376005.1 NP_001362934.1 general transcription factor IIH subunit 2-like protein isoform 5
NM_001376006.1 NP_001362935.1 general transcription factor IIH subunit 2-like protein isoform 6

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
24981860 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GTF2H2C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
GTF2H2C Q6P1K8 FAM43A Homo sapiens Q8N2R8
Validated Y2H
32296183
Intra
GTF2H2C Q6P1K8 FAM43A Homo sapiens Q8N2R8
Y2H Array
32296183
Intra
GTF2H2C Q6P1K8 FAM43A Homo sapiens Q8N2R8
Y2H Prey Pooling
32296183
Intra
GTF2H2C Q6P1K8 GTF2H3 Homo sapiens Q13889
Validated Y2H
25416956
Intra
GTF2H2C Q6P1K8 GTF2H3 Homo sapiens Q13889
Anti Tag CoIP
33961781
Intra
GTF2H2C Q6P1K8 GTF2H3 Homo sapiens Q13889
Anti Tag CoIP
28514442
Intra
GTF2H2C Q6P1K8 ERCC2 Homo sapiens P18074
Y2H Array
25416956
Intra
GTF2H2C Q6P1K8 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
GTF2H2C Q6P1K8 NR5A2 Homo sapiens O00482-2
Y2H Prey Pooling
32296183
Intra
GTF2H2C Q6P1K8 NR5A2 Homo sapiens O00482-2
Y2H Array
32296183
Intra
GTF2H2C Q6P1K8 DZIP3 Homo sapiens Q86Y13
Validated Y2H
25416956
Intra
GTF2H2C Q6P1K8 DZIP3 Homo sapiens Q86Y13
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS05899 GTF2H2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown