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Results for "

740

" in MedChemExpress (MCE) Product Catalog:

57

Inhibitors & Agonists

31

Fluorescent Dye

3

Peptides

4

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P0175
    740 Y-P
    240+ Cited Publications

    740YPDGFR; PDGFR 740Y-P

    PI3K Autophagy Cancer
    740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone .
    740 Y-P
  • HY-126247

    Ras Cancer
    BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.
    BI-2852
  • HY-19676
    Pralnacasan
    1 Publications Verification

    VX-740; HMR 3480

    Caspase Inflammation/Immunology
    Pralnacasan (VX-740) is a potent, selective, non-peptide and orally active interleukin-1β converting enzyme (ICE, caspase 1) inhibitor with a Ki of 1.4 nM. Pralnacasan inhibits proinflammatory cytokines IL-18, IL-1β , and IFN-γ. Pralnacasan has the potential for osteoarthritis and rheumatoid arthritis treatment .
    Pralnacasan
  • HY-118069
    (R)-ZINC-3573
    1 Publications Verification

    Mas-related G-protein-coupled Receptor (MRGPR) Infection
    (R)-ZINC-3573 is a selective Mas-related G protein-coupled receptor X2 (MRGPRX2) agonist with an EC50 value of 740 nM. (R)-ZINC-3573 can be used as a MRGPRX2 probe for the research of pain and itch .
    (R)-ZINC-3573
  • HY-135841
    CM010
    1 Publications Verification

    Aldehyde Dehydrogenase (ALDH) Metabolic Disease Cancer
    CM010 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM010 does not inhibit any of the other ALDH family members. CM010 can regulate metabolism and has anti-cancer activity .
    CM010
  • HY-112624F

    Fluorescent Dye Others
    CY7-Dextran (MW 4000) is a fluorescent dye that consists of CY7 (HY-D0825) and Dextran (HY-112624) (Ex=740 nm; Em=770 nm). CY7-Dextran (MW 4000) can be used as a cell volume indicator and delineates the thin peripheral edges of the cells .
    CY7-Dextran (MW 4000)
  • HY-114209
    MRK-740
    2 Publications Verification

    Histone Methyltransferase Cancer
    MRK-740, a chemical probe, is a potent, selective and substrate-competitive PRDM9 histone methyltransferase inhibitor with an IC50 of 80?nM. MRK-740 is more selective for PRDM9 than other histone methyltransferases and other non-epigenetic targets. MRK-740 reduces PRDM9-dependent trimethylation of H3K4 (IC50?=?0.8?μM) .
    MRK-740
  • HY-D2062

    Fluorescent Dye Integrin Cancer
    ATTO 740 NHS ester is a near-infrared fluorescent dye and a multimodal fluorescence/photoacoustic contrast agent with excellent near-infrared emission properties and extremely high photostability. The photoacoustic signal of ATTO 740 NHS ester shows no significant decrease after continuous irradiation with a 750 nm laser for 30 min, making it suitable for in vivo fluorescence imaging and photoacoustic contrast imaging. When conjugated with the cystine knot peptide R01, ATTO 740 NHS ester enables precise detection of integrin αvβ6-positive cells and tumors in nude mouse xenograft models .
    ATTO 740 NHS ester
  • HY-103416
    A-77636 hydrochloride
    1 Publications Verification

    Dopamine Receptor Neurological Disease
    A-77636 hydrochloride is a potent, orally active, selective and long acting dopamine D1 receptor agonist (pKi=7.40; Ki=39.8 nM) with antiparkinsonian activity. A-77636 hydrochloride is functionally inactive at dopamine D2 receptor .
    A-77636 hydrochloride
  • HY-D2873

    Sulfo Cy7(Et) tyramide

    Fluorescent Dye Others
    Sulfo Cy7 tyramide, a red fluorescent dye (Ex=740 nm, Em=770 nm), is utilized as reporter fluorescent substrate of horseradish peroxidase (HRP)-catalyzed deposition for tyramide signal amplification (TSA). Sulfo Cy7 tyramide can be used for multiplex Immunohistochemistry (mIHC) .
    Sulfo Cy7 tyramide
  • HY-110089

    P2Y Receptor Inflammation/Immunology
    mrs 4062 (TEA) is a selective P2Y4 receptor agonist with an EC50 of 23 nM. mrs 4062 (TEA) has EC50s of 640 nM and 740 nM for P2Y2 and P2Y6, respectively .
    mrs 4062 TEA
  • HY-D2060

    Fluorescent Dye Others
    ATTO 740 is a near-infrared dye (Ex/Em: 740/764 nm). ATTO 740 can be conjugated with the Cetuximab antibody (HY-P9905) .
    ATTO 740
  • HY-126247B

    Drug Derivative Ras Cancer
    (R)-BI-2852 is the isomer of BI-2852 (HY-126247), and can be used as an experimental control. BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.
    (R)-BI-2852
  • HY-79572

    Parasite Infection
    4-Methyl-3-nitrophenol is a phenolic compound classified as a soft electrophile. 4-Methyl-3-nitrophenol is toxic to ciliates, with a log IC50 value of -3.740 against T. pyriformis .
    4-Methyl-3-nitrophenol
  • HY-176820

    Histone Methyltransferase Cancer
    MRK-740-NC is a PRDM7/9 histone methyltransferase inhibitor. MRK-740-NC is a negative control compound of MRK-740 (HY-114209). MRK-740-NC has no inhibitory activity for PRDM7 and PRDM9 by replacing the methyl pyridine moiety of MRK-740 by a phenyl group .
    MRK-740-NC
  • HY-124086

    5-HT Receptor Neurological Disease
    BHQ-O-5HT is a light-activated caged 5-HT protected by a BHQ group. When exposed to light at 365 or 740 nm, BHQ-O-5HT releases 5-HT through 1 or 2 photon excitation, respectively. BHQ-O-5HT can be manipulated in space and time to explore the role of 5-HT in regulating mood, appetite, memory, learning, and other cognitive functions .
    BHQ-O-5HT
  • HY-P0175A

    740YPDGFR TFA; PDGFR 740Y-P TFA

    PI3K Autophagy Cancer
    740 Y-P TFA is a potent and cell-permeable PI3K activator. 740 Y-P TFA readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone .
    740 Y-P TFA
  • HY-D2676

    Fluorescent Dye Others
    Cy7 HA (MW 3000) is a hyaluronic acid labeled with CY7 (HY-D0825). Cy7 HA (MW 3000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 740/770 nm).
    Cy7 HA (MW 50000)
  • HY-150970

    Pyroptosis Cancer
    ICy-OH, an iodinated photosensitizer, is an effective anticancer agent. ICy-OH can be used not only for deep tissue imaging (λex=640 nm,λem=690-740 nm) but also to selectively induce cell death in pancreatic cancer cells via cell pyroptosis pathway .
    ICy-OH
  • HY-141496

    Dopamine Receptor Neurological Disease
    A-77636 is an orally active, potent, selective and long-acting dopamine D1 receptor agonist (pEC50 = 8.13; EC50 = 1.1 nM). A-77636 shows the highest affinity (pKi = 7.40 ± 0.09; Ki = 39.8 nM) for the dopamine D1 receptor. A-77636 shows antiparkinsonian activity .
    A-77636
  • HY-D2061

    Fluorescent Dye Others
    ATTO 740 carboxy is a carboxyl derivative of ATTO 740, the maximum excitation/emission wavelength is: 743/763 nm.
    ATTO 740 carboxy
  • HY-D2076

    Fluorescent Dye Others
    ATTO 740 biotin is a biotin derivative of ATTO 740 with maximum excitation/emission wavelengths: 743/763 nm.
    ATTO 740 biotin
  • HY-18332B

    Dopamine Transporter Adrenergic Receptor 5-HT Receptor Neurological Disease
    DOV-102,677 is an orally sctive triple monoamine neurotransmitter reuptake inhibitor that simultaneously inhibits the dopamine (DAT) (IC50 = 129 nM; Ki = 222 nM), norepinephrine (NET) (IC50 = 103 nM; Ki = 1030 nM), and serotonin (SERT) (IC50 = 133 nM; Ki = 740 nM) transporters. DOV-102,677 demonstrated significant antidepressant-like activity and sensory-motor gating regulatory effects in mouse experiments. DOV-102,677 can be used for research on depression .
    DOV-102,677
  • HY-D2075

    Fluorescent Dye Others
    ATTO 740 streptavidin is a streptavidin derivative of ATTO 740, it can label protein or antibody, the maximum excitation/emission wavelength: 743/763 nm.
    ATTO 740 streptavidin
  • HY-D2063

    Fluorescent Dye Others
    ATTO 740 maleimide is a new fluorescent marker based on the Rhodamine structure. It has strong absorption, high fluorescence quantum yield, high thermal stability and photochemical stability, and is suitable for single molecule detection and high-resolution microscopy. ATTO 740 maleimide is a maleimide derivative of ATTO 740, which can be used to label proteins or antibodies.
    ATTO 740 maleimide
  • HY-W953385

    Ligands for E3 Ligase Cancer
    CRBN ligand-740 is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. CRBN ligand-740 can be linked to a target protein ligand via a linker to form a PROTAC.
    CRBN ligand-740
  • HY-RS16171

    Small Interfering RNA (siRNA) Others

    ZNF740 Human Pre-designed siRNA Set A contains three designed siRNAs for ZNF740 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ZNF740 Human Pre-designed siRNA Set A
    ZNF740 Human Pre-designed siRNA Set A
  • HY-P2515

    Histone Acetyltransferase Others
    Transcriptional Intermediary Factor 2 (TIF2) (740-753) is a TIF-2 coactivator peptide composed of 14 amino acids and covers the residue range 740-753 of TIF-2 protein .
    Transcriptional Intermediary Factor 2 (TIF2) (740-753)
  • HY-100570

    Prostaglandin Receptor Inflammation/Immunology
    KF15766 (compd 34E) is an orally active TXA2 and H1 dual antagonist with Kis of 740 and 20 nM. KF15766 can be used for antiallergic research .
    KF15766
  • HY-D2677

    Fluorescent Dye Others
    Cy7 HA (MW 100000) is a hyaluronic acid labeled with CY7 (HY-D0825). Cy7 HA (MW 100000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 740/770 nm).
    Cy7 HA (MW 100000)
  • HY-D2675

    Fluorescent Dye Others
    Cy7 HA (MW 10000) is a hyaluronic acid labeled with CY7 (HY-D0825). Cy7 HA (MW 10000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 740/770 nm).
    Cy7 HA (MW 10000)
  • HY-D2674

    Fluorescent Dye Others
    Cy7 HA (MW 7000) is a hyaluronic acid labeled with CY7 (HY-D0825). Cy7 HA (MW 7000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 740/770 nm).
    Cy7 HA (MW 7000)
  • HY-D2672

    Fluorescent Dye Others
    Cy7 HA (MW 3000) is a hyaluronic acid labeled with CY7 (HY-D0825). Cy7 HA (MW 3000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 740/770 nm).
    Cy7 HA (MW 3000)
  • HY-D2687

    Fluorescent Dye Others
    Cy7 HA biotin 5000 is a biotinylated hyaluronic acid labeled with CY7 (HY-D0825). Cy7 HA biotin 5000 is widely used for cell imaging and in vivo imaging of shallow tissues (Ex/Em = 740/770 nm).
    Cy7 HA biotin 5000
  • HY-D2688

    Fluorescent Dye Others
    Cy7 HA biotin 10000 is a biotinylated hyaluronic acid labeled with CY7 (HY-D0825). Cy7 HA biotin 10000 is widely used for cell imaging and in vivo imaging of shallow tissues (Ex/Em = 740/770 nm).
    Cy7 HA biotin 10000
  • HY-D2852

    Fluorescent Dye Others
    Heparin-Cy7 is a fluorescent dye composed of CY7 (HY-D0825) and heparin. Heparin-CY7 is used to study the localization and distribution of heparin in vivo and its interaction with other biomolecules (Ex/Em = 740/770 nm).
    Heparin-Cy7
  • HY-D2685

    Fluorescent Dye Others
    Cy7 HA MA (MW 100000) is a hyaluronic acid methacrylate labeled with CY7 (HY-D0825). Cy7 HA MA (MW 100000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 740/770 nm).
    Cy7 HA MA (MW 100000)
  • HY-D2681

    Fluorescent Dye Others
    Cy7 HA MA (MW 3000) is a hyaluronic acid methacrylate labeled with CY7 (HY-D0825). Cy7 HA MA (MW 3000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 740/770 nm).
    Cy7 HA MA (MW 3000)
  • HY-D2683

    Fluorescent Dye Others
    Cy7 HA MA (MW 10000) is a hyaluronic acid methacrylate labeled with CY7 (HY-D0825). Cy7 HA MA (MW 10000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 740/770 nm).
    Cy7 HA MA (MW 10000)
  • HY-D2684

    Fluorescent Dye Others
    Cy7 HA MA (MW 50000) is a hyaluronic acid methacrylate labeled with CY7 (HY-D0825). Cy7 HA MA (MW 50000) is widely used in the fields of biolabeling and imaging, drug delivery and tissue engineering and regenerative medicine (Ex/Em = 740/770 nm).
    Cy7 HA MA (MW 50000)
  • HY-162045

    Biochemical Assay Reagents Cancer
    Ru-4T is a phototherapy agent. Ru-4T has phototherapeutic efficacy (PI = 114,000) against melanoma cells (SK-MEL-28) under broad-band visible light (400-700 nm) with EC50 values of 740 pM .
    Ru-4T
  • HY-D3005

    Fluorescent Dye Autophagy Inflammation/Immunology
    NpCy-4 is a reliable reporter for monitoring lysosomal pH and viscosity changes in real time during Autophagy (λex = 650 nm; λem = 660-740 nm). NpCy-4 demonstrates a superior signal-to-background ratio (SBR) for cellular imaging. NpCy-4 facilitates real-time, noninvasive diagnostic imaging of acute gastritis model with high contrast .
    NpCy-4
  • HY-136675

    Fluorescent Dye Others
    ASMI is a ratiometric, two-photon excited fluorescent probe, composed of a highly two-photon active and biocompatible merocyanine fluorophore and an acrylate moiety as a thiol reactive site. ASMI is able to selectively detect and monitor mitochondrial Cys with rapid responsiveness, imaging living cells and intact tissues with high contrast and brightness at a depth of 150 μm. The two-photon action cross section (Φσmax) of ASMI is 65.2 GM, corresponding to an excitation wavelength (λex) of 740 nm.
    ASMI
  • HY-172966

    EGFR Cancer
    EG31 is an EGFR inhibitor. EG31 effectively inhibits the proliferation of triple-negative breast cancer (TNBC) cells (GI50 values of MDA-MB-231 and Hs578T cells are 498.90 nM and 740.73 nM, respectively) and induces apoptosis by inhibiting the EGFR signaling pathway. EG31 still maintains antiproliferative activity against 5-fluorouracil (5-FU)-resistant TNBC cells (GI50: 519.5 nM). EG31 can be used to study TNBC resistance .
    EG31
  • HY-171448

    Others Inflammation/Immunology
    SU-740 is a chalcone derivative with anti-ulcer activity .
    SU-740
  • HY-D3152

    Fluorescent Dye Others
    NRh-Cu is a highly sensitive near-infrared fluorescence turn-on indicator and Cu 2+-selective probe (λex=680 nm, λem=740 nm). When NRh-Cu interacts with Cu 2+, it undergoes a structural transition from a non-fluorescent spirocyclic state to a fluorescent ring-opened state, which drives the enhancement of fluorescence emission. NRh-Cu can be used for Cu 2+ imaging in live cells and in vivo .
    NRh-Cu
  • HY-D2680

    Fluorescent Dye Others
    Cy7 HA (MW 200000) is a hyaluronic acid labeled with CY7 (HY-D0825). Cy7 HA (MW 200000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 740/770 nm).
    Cy7 HA (MW 200000)
  • HY-D2678

    Fluorescent Dye Others
    Cy7 HA (MW 500000) is a hyaluronic acid labeled with CY7 (HY-D0825). Cy7 HA (MW 500000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 740/770 nm).
    Cy7 HA (MW 500000)
  • HY-D2673

    Fluorescent Dye Others
    Cy7 HA (MW 55000) is a hyaluronic acid labeled with CY7 (HY-D0825). Cy7 HA (MW 5000) is widely used for cell imaging and in vivo imaging of shallow tissue (Ex/Em = 740/770 nm).
    Cy7 HA (MW 5000)
  • HY-D2686

    Fluorescent Dye Others
    Cy7 HA biotin 3000 is a biotinylated hyaluronic acid labeled with CY7 (HY-D0825). Cy7 HA biotin 3000 is widely used for cell imaging and in vivo imaging of shallow tissues (Ex/Em = 740/770 nm).
    Cy7 HA biotin 3000

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