ZKSCAN1 - zinc finger with KRAB and SCAN domains 1 Gene

Also Known as KOX18; ZNF36; PHZ-37; ZNF139; ZSCAN33

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7586

About ZKSCAN1

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,015,596-100,045,374 (from NCBI)

This gene has 6 transcripts (splice variants), 94 orthologues and 31 paralogues. Ubiquitous expression in stomach (RPKM 13.7), skin (RPKM 12.9) and 25 other tissues.

Summary

This gene encodes a member of the Kruppel C2H2-type zinc-finger family of proteins. This encoded protein may function as a transcription factor that regulates the expression of GABA type-A receptors in the brain. Transcripts from this gene have been shown to form stable and abundant circular RNAs. Elevated expression of this gene has been observed in gastric Cancer and the encoded protein may stimulate migration and invasion of human gastric Cancer cells. [provided by RefSeq, Oct 2016]

ZKSCAN1 Products (6)

mRNA Protein Name
NM_001287054.3 NP_001273983.1 zinc finger protein with KRAB and SCAN domains 1 isoform b
NM_001287055.3 NP_001273984.1 zinc finger protein with KRAB and SCAN domains 1 isoform c
NM_001346579.2 NP_001333508.1 zinc finger protein with KRAB and SCAN domains 1 isoform d
NM_001346580.2 NP_001333509.1 zinc finger protein with KRAB and SCAN domains 1 isoform b
NM_001346581.2 NP_001333510.1 zinc finger protein with KRAB and SCAN domains 1 isoform a
NM_003439.4 NP_003430.1 zinc finger protein with KRAB and SCAN domains 1 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZKSCAN1 Protein Structure

SCAN

SCAN: SCAN domain (51 - 140)

KRAB

KRAB: KRAB box (227 - 262)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (392 - 415)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (419 - 444)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (448 - 471)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (475 - 499)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (507 - 528)

  • 0
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  • 200
  • 300
  • 400
  • 500
  • 563 a.a.
Protein Preferred Names Protein Names

zinc finger protein with KRAB and SCAN domains 1

  • zinc finger protein 139

ZKSCAN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZKSCAN1 P17029 MAPK7 Homo sapiens Q13164
Validated Y2H
32296183
Intra
ZKSCAN1 P17029 MAPK7 Homo sapiens Q13164
Y2H Array
32296183
Intra
ZKSCAN1 P17029 MAPK7 Homo sapiens Q13164
Y2H Prey Pooling
32296183
Intra
ZKSCAN1 P17029 ZSCAN32 Homo sapiens Q9NX65
Y2H Prey Pooling
25416956
Intra
ZKSCAN1 P17029 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Intra
ZKSCAN1 P17029 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Intra
ZKSCAN1 P17029 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16081 ZKSCAN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZKSCAN1 VGNC VGNC:78899
Canis familiaris ZKSCAN1 VGNC VGNC:54094
Rattus norvegicus ZKSCAN1 RGD RGD:1560616
Mus musculus ZKSCAN1 MGD MGI:1921820
Bos taurus ZKSCAN1 VGNC VGNC:37188
Others ZKSCAN1 NCBI