KCTD15 - potassium channel tetramerization domain containing 15 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79047

About KCTD15

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:33,794,040-33,815,761 (from NCBI)

This gene has 13 transcripts (splice variants), 258 orthologues and 13 paralogues. Broad expression in skin (RPKM 22.8), endometrium (RPKM 7.8) and 21 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in protein homooligomerization. [provided by Alliance of Genome Resources, Apr 2022]

KCTD15 Products (3)

mRNA Protein Name
NM_001129994.2 NP_001123466.1 BTB/POZ domain-containing protein KCTD15 isoform 2
NM_001129995.2 NP_001123467.1 BTB/POZ domain-containing protein KCTD15 isoform 2
NM_024076.3 NP_076981.2 BTB/POZ domain-containing protein KCTD15 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
27152988 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCTD15 Protein Structure

BTB_2

BTB_2: BTB/POZ domain (58 - 146)

  • 0
  • 100
  • 200
  • 283 a.a.
Protein Preferred Names Protein Names

BTB/POZ domain-containing protein KCTD15

  • potassium channel tetramerisation domain containing 15

KCTD15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KCTD15 Q96SI1 WIPI1 Homo sapiens Q5MNZ9
Y2H Pooling
16169070
Intra
KCTD15 Q96SI1 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra
KCTD15 Q96SI1 ATXN1 Homo sapiens P54253
Y2H Prey Pooling
23275563
Intra
KCTD15 Q96SI1 KCTD1 Homo sapiens Q719H9
Y2H Prey Pooling
25416956
Intra
KCTD15 Q96SI1 TRIM27 Homo sapiens P14373
Y2H Pooling
16169070
Intra
KCTD15 Q96SI1 KCTD15 Homo sapiens Q96SI1
EM
27152988
Intra
KCTD15 Q96SI1 REN Homo sapiens P00797
Y2H Pooling
16169070
Intra
KCTD15 Q96SI1 ENSA Homo sapiens O43768
Y2H Pooling
16169070
Intra
KCTD15 Q96SI1 KCTD1 Homo sapiens Q719H9
Y2H Array
25416956
Intra
KCTD15 Q96SI1 KCTD15 Homo sapiens Q96SI1
GMS
27152988
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Scalp-Ear-Nipple Syndrome

  • Finlay-Marks Syndrome

  • Sen Syndrome

  • SENS

  • Scalp Ear Nipple Syndrome

  • Hereditary Syndrome Of Lumpy Scalp, Odd Ears And Rudimentary Nipples

  • Hereditary Syndrome Of Lumpy Scalp, Odd Ears, And Rudimentary Nipples

  • Indian Childhood Cirrhosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07192 KCTD15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta KCTD15 VGNC VGNC:73894
Bos taurus KCTD15 VGNC VGNC:30504
Canis familiaris KCTD15 VGNC VGNC:42303
Felis catus KCTD15 VGNC VGNC:63055
Mus musculus KCTD15 MGD MGI:2385276
Rattus norvegicus KCTD15 RGD RGD:1583737
Others KCTD15 NCBI