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DCTPP1 - dCTP pyrophosphatase 1 Gene

Also Known as CDA03; RS21C6; XTP3TPA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79077

About DCTPP1

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,423,615-30,430,030 (from NCBI)

This gene has 6 transcripts (splice variants) and 175 orthologues. Ubiquitous expression in colon (RPKM 23.2), lymph node (RPKM 13.8) and 25 other tissues.

Summary

The protein encoded by this gene is dCTP pyrophosphatase, which converts dCTP to dCMP and inorganic pyrophosphate. The encoded protein also displays weak activity against dTTP and dATP, but none against dGTP. This protein may be responsible for eliminating excess dCTP after DNA synthesis and may prevent overmethylation of CpG islands. Three transcript variants, one protein-coding and the Other two non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]

DCTPP1 Products (1)

mRNA	Protein	Name
NM_024096.2	NP_077001.1	dCTP pyrophosphatase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables dCTP diphosphatase activity	IDA IDA: Inferred from direct assay	24467396	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA
enables nucleoside triphosphate diphosphatase activity	IDA IDA: Inferred from direct assay	24467396	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA protection	IMP IMP: Inferred from mutant phenotype	24467396	GOA
involved in dCTP catabolic process	IMP IMP: Inferred from mutant phenotype	24467396	GOA
NOT involved in dTTP catabolic process	IMP IMP: Inferred from mutant phenotype	24467396	GOA
involved in nucleoside triphosphate catabolic process	IDA IDA: Inferred from direct assay	24467396	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	24467396	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	24467396	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24467396	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCTPP1 Protein Structure

MazG

0
100
170 a.a.

Protein Preferred Names	Protein Names
dCTP pyrophosphatase 1	XTP3-transactivated gene A protein

DCTPP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DCTPP1	Q9H773	CEP192	Homo sapiens	Q8TEP8	Anti Tag CoIP	28514442
Intra	DCTPP1	Q9H773	CEP192	Homo sapiens	Q8TEP8	Anti Tag CoIP	33961781
Intra	DCTPP1	Q9H773	DCTPP1	Homo sapiens	Q9H773	Y2H Prey Pooling	32296183
Intra	DCTPP1	Q9H773	SDCBP	Homo sapiens	O00560	Y2H Array	25416956
Intra	DCTPP1	Q9H773	GCD7	Saccharomyces cerevisiae	P32502	Validated Y2H	27107014
Intra	DCTPP1	Q9H773	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	DCTPP1	Q9H773	DCTPP1	Homo sapiens	Q9H773	Validated Y2H	32296183
Intra	DCTPP1	Q9H773	DCTPP1	Homo sapiens	Q9H773	Y2H Array	25416956
Intra	DCTPP1	Q9H773	PRE5	Saccharomyces cerevisiae	P40302	Validated Y2H	27107014
Intra	DCTPP1	Q9H773	GCD7	Saccharomyces cerevisiae	P32502	Y2H Array	27107014
Intra	DCTPP1	Q9H773	SDCBP	Homo sapiens	O00560	Validated Y2H	25416956
Intra	DCTPP1	Q9H773	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	DCTPP1	Q9H773	DCTPP1	Homo sapiens	Q9H773	Y2H Array	32296183
Intra	DCTPP1	Q9H773	NTAQ1	Homo sapiens	Q96HA8	Y2H Pooling	16189514
Intra	DCTPP1	Q9H773	PRE5	Saccharomyces cerevisiae	P40302	Y2H Array	27107014
Intra	DCTPP1	Q9H773	DCTPP1	Homo sapiens	Q9H773	Y2H Pooling	16189514
Intra	DCTPP1	Q9H773	DCTPP1	Homo sapiens	Q9H773	Y2H Pooling	16169070
Intra	DCTPP1	Q9H773	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	DCTPP1	Q9H773	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	31515488
Intra	DCTPP1	Q9H773	PRE5	Saccharomyces cerevisiae	P40302	Y2H Pooling	27107014

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DCTPP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77508	XTP3TPA Protein, Human (His)	Q9H773 (M1-T170)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Buschke-Ollendorff Syndrome	BOS Dermatoosteopoikilosis Dermatofibrosis Lenticularis Disseminata With Osteopoikilosis Osteopathia Condensans Disseminata Dermatofibrosis Lenticularis Disseminata Disseminated Dermatofibrosis With Osteopoikilosis Dermatofibrosis, Disseminated, With Osteopoikilosis Osteopoikilosis With Or Without Melorheostosis Dermatofibrosis, Disseminated With Osteopoikilosis Dermatofibrosis Disseminata Lenticularis Isolated Osteopoikilosis Osteopoikilosis, Isolated

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03597	DCTPP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-160596	5-Formyl-dCTP lithium		/	Unkown
HY-182416	slCeMM1	Inhibitor	/	Unkown
HY-RS19773	Dctpp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26270	Dctpp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DCTPP1	MGD	MGI:1913672
Macaca mulatta	DCTPP1	VGNC	VGNC:104692
Bos taurus	DCTPP1	VGNC	VGNC:27934
Rattus norvegicus	DCTPP1	RGD	RGD:620933
Felis catus	DCTPP1	VGNC	VGNC:80562
Others	DCTPP1	NCBI