FASTKD1 - FAST kinase domains 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79675

About FASTKD1

Cytogenetic location: 2q31.1 Genomic coordinates (GRCh38): 2:169,528,508-169,573,865 (from NCBI)

This gene has 10 transcripts (splice variants), 192 orthologues and 5 paralogues. Ubiquitous expression in heart (RPKM 4.3), duodenum (RPKM 3.9) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in mitochondrial RNA metabolic process and regulation of mitochondrial mRNA stability. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

FASTKD1 Products (5)

mRNA Protein Name
NM_001281476.3 NP_001268405.1 FAST kinase domain-containing protein 1, mitochondrial isoform 2
NM_001322046.2 NP_001308975.1 FAST kinase domain-containing protein 1, mitochondrial isoform 1
NM_001322048.2 NP_001308977.1 FAST kinase domain-containing protein 1, mitochondrial isoform 3
NM_001322049.2 NP_001308978.1 FAST kinase domain-containing protein 1, mitochondrial isoform 4
NM_024622.6 NP_078898.3 FAST kinase domain-containing protein 1, mitochondrial isoform 1

FASTKD1 Protein Structure

FAST_1

FAST_1: FAST kinase-like protein, subdomain 1 (575 - 643)

FAST_2

FAST_2: FAST kinase-like protein, subdomain 2 (657 - 743)

RAP

RAP: RAP domain (781 - 837)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 847 a.a.
Protein Preferred Names Protein Names

FAST kinase domain-containing protein 1, mitochondrial

FASTKD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FASTKD1 Q53R41 EIF2S3 Homo sapiens P41091
Y2H Array
32814053
Intra
FASTKD1 Q53R41 EIF2S3 Homo sapiens P41091
Y2H Pooling
32814053
Intra
FASTKD1 Q53R41 EIF2S3 Homo sapiens P41091
Validated Y2H
32814053
Intra
FASTKD1 Q53R41 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
FASTKD1 Q53R41 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
FASTKD1 Q53R41 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
FASTKD1 Q53R41 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
FASTKD1 Q53R41 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
FASTKD1 Q53R41 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
FASTKD1 Q53R41 ST13 Homo sapiens Q9P1I4
Y2H Pooling
32814053
Intra
FASTKD1 Q53R41 ST13 Homo sapiens Q9P1I4
Validated Y2H
32814053
Intra
FASTKD1 Q53R41 ST13 Homo sapiens Q9P1I4
Y2H Array
32814053
Intra
FASTKD1 Q53R41 HSPA2 Homo sapiens P54652
Validated Y2H
32814053
Intra
FASTKD1 Q53R41 HSPA2 Homo sapiens P54652
Y2H Array
32814053
Intra
FASTKD1 Q53R41 HSPA2 Homo sapiens P54652
Y2H Pooling
32814053
Intra
FASTKD1 Q53R41 P4HB Homo sapiens P07237
Validated Y2H
32814053
Intra
FASTKD1 Q53R41 P4HB Homo sapiens P07237
Y2H Array
32814053
Intra
FASTKD1 Q53R41 P4HB Homo sapiens P07237
Y2H Pooling
32814053
Intra
FASTKD1 Q53R41 NEFL Homo sapiens P07196
Y2H Pooling
32814053
Intra
FASTKD1 Q53R41 NEFL Homo sapiens P07196
Validated Y2H
32814053
Intra
FASTKD1 Q53R41 NEFL Homo sapiens P07196
Y2H Array
32814053
Intra
FASTKD1 Q53R41 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
FASTKD1 Q53R41 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
FASTKD1 Q53R41 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
FASTKD1 Q53R41 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra
FASTKD1 Q53R41 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra
FASTKD1 Q53R41 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra
FASTKD1 Q53R41 GRN Homo sapiens P28799
Validated Y2H
32814053
Intra
FASTKD1 Q53R41 GRN Homo sapiens P28799
Y2H Pooling
32814053
Intra
FASTKD1 Q53R41 GRN Homo sapiens P28799
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Glaucoma 1, Open Angle, B

  • GLC1B

  • Glaucoma 1b, Primary Open Angle, Adult Onset
Mitochondrial Encephalomyopathy

  • Mitochondrial Encephalomyopathies

  • Encephalomyopathy, Mitochondrial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04757 FASTKD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FASTKD1 VGNC VGNC:28873
Rattus norvegicus FASTKD1 RGD RGD:1563531
Canis familiaris FASTKD1 VGNC VGNC:40738
Felis catus FASTKD1 VGNC VGNC:62154
Mus musculus FASTKD1 MGD MGI:2444596
Macaca mulatta FASTKD1 VGNC VGNC:72580
Others FASTKD1 NCBI