DOK3 - docking protein 3 Gene

Also Known as DOKL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79930

About DOK3

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,501,904-177,511,100 (from NCBI)

This gene has 13 transcripts (splice variants), 122 orthologues and 7 paralogues. Biased expression in bone marrow (RPKM 31.4), spleen (RPKM 15.5) and 11 other tissues.

Summary

Predicted to be involved in Ras protein signal transduction and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to be located in ficolin-1-rich granule membrane and plasma membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DOK3 Products (14)

mRNA Protein Name
NM_001144875.2 NP_001138347.1 docking protein 3 isoform 2
NM_001144876.2 NP_001138348.1 docking protein 3 isoform 3
NM_001308235.3 NP_001295164.1 docking protein 3 isoform 1
NM_001308236.3 NP_001295165.1 docking protein 3 isoform 1
NM_001375794.1 NP_001362723.1 docking protein 3 isoform 1
NM_001375795.1 NP_001362724.1 docking protein 3 isoform 1
NM_001375796.1 NP_001362725.1 docking protein 3 isoform 1
NM_001375797.2 NP_001362726.1 docking protein 3 isoform 1
NM_001375798.1 NP_001362727.1 docking protein 3 isoform 2
NM_001375799.2 NP_001362728.1 docking protein 3 isoform 2
NM_001384137.1 NP_001371066.1 docking protein 3 isoform 1
NM_001384138.1 NP_001371067.1 docking protein 3 isoform 4
NM_001384139.1 NP_001371068.1 docking protein 3 isoform 4
NM_024872.4 NP_079148.3 docking protein 3 isoform 1

DOK3 Protein Structure

IRS

IRS: PTB domain (IRS-1 type) (216 - 311)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 496 a.a.
Protein Preferred Names Protein Names

docking protein 3

  • Dok-like protein

DOK3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DOK3 Q7L591 EGFR Homo sapiens P00533
Ub Reconstruction
27956147
Intra
DOK3 Q7L591 EGFR Homo sapiens P00533
Anti Tag CoIP
27956147
Intra
DOK3 Q7L591 TRAF1 Homo sapiens Q13077
Y2H Array
25416956
Intra
DOK3 Q7L591 TRAF1 Homo sapiens Q13077
Validated Y2H
25416956
Intra
DOK3 Q7L591 RBPMS Homo sapiens Q93062
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Histiocytic And Dendritic Cell Cancer

  • Histiocytic And Dendritic Cell
Histiocytic Sarcoma

  • Malignant Histiocytosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03935 DOK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22144 Dok3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28665 Dok3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DOK3 RGD RGD:1311840
Canis familiaris DOK3 VGNC VGNC:40057
Mus musculus DOK3 MGD MGI:1351490
Macaca mulatta DOK3 VGNC VGNC:71897
Felis catus DOK3 VGNC VGNC:61582
Bos taurus DOK3 VGNC VGNC:28167
Others DOK3 NCBI