Ogg1 - 8-oxoguanine DNA glycosylase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81528

Summary

Enables damaged DNA binding activity and oxidized purine nucleobase lesion DNA N-glycosylase activity. Involved in several processes, including cellular response to cadmium ion; response to estradiol; and response to folic acid. Located in mitochondrion and nucleus. Biomarker of hepatitis; middle cerebral artery infarction; renal cell carcinoma; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; angiomyolipoma; carcinoma (multiple); eye disease (multiple); and reproductive organ Cancer (multiple). Orthologous to human OGG1 (8-oxoguanine DNA glycosylase). [provided by Alliance of Genome Resources, Apr 2022]

Ogg1 Products (1)

mRNA Protein Name
NM_030870.1 NP_110497.1 N-glycosylase/DNA lyase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables DNA N-glycosylase activity IDA
IDA: Inferred from direct assay
9801319 RGD
enables damaged DNA binding IDA
IDA: Inferred from direct assay
9801319 RGD
enables oxidized purine nucleobase lesion DNA N-glycosylase activity IDA
IDA: Inferred from direct assay
9801319 RGD
Biological Process GO Annotation Evidence Références Source
involved in base-excision repair IDA
IDA: Inferred from direct assay
9801319 RGD
involved in cellular response to cadmium ion IEP
IEP: Inferred from expression pattern
12499121 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20969951 RGD
involved in response to estradiol IDA
IDA: Inferred from direct assay
16182450 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
11524300 RGD
involved in response to folic acid IEP
IEP: Inferred from expression pattern
20051376 RGD
involved in response to light stimulus IEP
IEP: Inferred from expression pattern
15979612 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11872643 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

N-glycosylase/DNA lyase

  • 8-oxoguanine DNA-glycosylase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-147313 TH10785 Activator 99.93% Unkown
HY-112902 OGG1-IN-08 Inhibitor 99.18% Unkown
HY-139056 SU0268 Inhibitor 99.96% Unkown
HY-RS09763 OGG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179014 OGG1 activator-1 Activator / Unkown
HY-180404 SU0383 Inhibitor / Unkown
HY-RS16757 Ogg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23196 Ogg1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ogg1 NCBI NCBI:4968