TDRD3 - tudor domain containing 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 81550

About TDRD3

Cytogenetic location: 13q21.2 Genomic coordinates (GRCh38): 13:60,395,533-60,573,879 (from NCBI)

This gene has 9 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in testis (RPKM 6.2), thyroid (RPKM 5.5) and 25 other tissues.

Summary

Enables chromatin binding activity; methylated histone binding activity; and transcription coactivator activity. Predicted to be involved in chromatin organization and positive regulation of transcription, DNA-templated. Located in Golgi apparatus; cytosol; and nucleoplasm. Colocalizes with exon-exon junction complex. [provided by Alliance of Genome Resources, Apr 2022]

TDRD3 Products (3)

mRNA	Protein	Name
NM_001146070.2	NP_001139542.1	tudor domain-containing protein 3 isoform 1
NM_001146071.1	NP_001139543.1	tudor domain-containing protein 3 isoform 2
NM_030794.2	NP_110421.1	tudor domain-containing protein 3 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	21172665	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	21172665	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23066109	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	21172665	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of DNA topoisomerase III-beta-TDRD3 complex	IPI IPI: Inferred from physical interaction	28176834	GOA
part of exon-exon junction complex	IDA IDA: Inferred from direct assay	20930030	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21172665	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TDRD3 Protein Structure

UBA

TUDOR

0
100
200
300
400
500
600
651 a.a.

Protein Preferred Names	Protein Names
tudor domain-containing protein 3

TDRD3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TDRD3	Q9H7E2	POLR2A	Homo sapiens	P24928	Fluorescence Spectr	23066109
Intra	TDRD3	Q9H7E2	POLR2A	Homo sapiens	P24928	NMR	23066109

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14336	TDRD3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TDRD3	VGNC	VGNC:97224
Rattus norvegicus	TDRD3	RGD	RGD:1310126
Bos taurus	TDRD3	VGNC	VGNC:35718
Mus musculus	TDRD3	MGD	MGI:2444023
Macaca mulatta	TDRD3	VGNC	VGNC:79258
Felis catus	TDRD3	VGNC	VGNC:66047
Others	TDRD3	NCBI