Amd1 - adenosylmethionine decarboxylase 1 Gene

Also Known as Amd1a; Amd1b

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81640

Summary

Enables adenosylmethionine decarboxylase activity and putrescine binding activity. Involved in S-adenosylmethionine metabolic process; spermidine biosynthetic process; and spermine biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human AMD1 (adenosylmethionine decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]

Amd1 Products (1)

mRNA Protein Name
NM_031011.4 NP_112273.3 S-adenosylmethionine decarboxylase proenzyme

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables adenosylmethionine decarboxylase activity IDA
IDA: Inferred from direct assay
1415709 RGD
enables putrescine binding IDA
IDA: Inferred from direct assay
21048303 RGD
Biological Process GO Annotation Evidence References Source
involved in S-adenosylmethionine metabolic process IDA
IDA: Inferred from direct assay
1415709 RGD
involved in polyamine metabolic process IDA
IDA: Inferred from direct assay
10430362 RGD
involved in spermidine biosynthetic process IDA
IDA: Inferred from direct assay
1415709 RGD
involved in spermidine biosynthetic process IMP
IMP: Inferred from mutant phenotype
10712236 RGD
involved in spermine biosynthetic process IDA
IDA: Inferred from direct assay
1415709 RGD
involved in spermine biosynthetic process IMP
IMP: Inferred from mutant phenotype
10712236 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

S-adenosylmethionine decarboxylase proenzyme

  • S-Adenosylmethionine decarboxylase 1B

  • S-adenosylmethionine decarboxylase 1

  • S-adenosylmethionine decarboxylase 1A

  • SAMDC

  • adoMetDC

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109561 Pegaptanib sodium Inhibitor 90.51% Unkown

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-P3252A Pegcetacoplan acetate Inhibitor 99.92% Phase 3
HY-19720A Emixustat hydrochloride Inhibitor 99.29% Phase 3
HY-N0679S Retinyl acetate-d3 / Phase 3
HY-15492 AG-13958 Inhibitor 99.69% Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99629 Galegenimab Inhibitor 99.91% Phase 2

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19720 Emixustat 98.00% Yes
HY-132126 SPHINX Inhibitor 99.87% Unkown
HY-RS09498 NPR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-15492A AG-13958 (mono(hydrochloride)) Inhibitor / Unkown
HY-RS00644 AMD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W888515 mPEG-PCL / Unkown
HY-RS18124 Amd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24598 Amd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Amd1 NCBI NCBI:262