Plekha2 - pleckstrin homology domain containing A2 Gene

Also Known as TAPP2; 6430512N22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 83436

Summary

Enables PDZ domain binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in positive regulation of cell-matrix adhesion. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including bone; central nervous system; jaw; Thymus primordium; and vomeronasal organ. Orthologous to human PLEKHA2 (pleckstrin homology domain containing A2). [provided by Alliance of Genome Resources, Jul 2025]
Broad expression in spleen adult (RPKM 8.9), bladder adult (RPKM 7.3) and 25 other tissues.

Plekha2 Products (8)

mRNA Protein Name
NM_001427346.1 NP_001414275.1 pleckstrin homology domain-containing family A member 2 isoform 1
NM_001427347.1 NP_001414276.1 pleckstrin homology domain-containing family A member 2 isoform 1
NM_001427348.1 NP_001414277.1 pleckstrin homology domain-containing family A member 2 isoform 1
NM_001427349.1 NP_001414278.1 pleckstrin homology domain-containing family A member 2 isoform 1
NM_001427350.1 NP_001414279.1 pleckstrin homology domain-containing family A member 2 isoform 1
NM_001427351.1 NP_001414280.1 pleckstrin homology domain-containing family A member 2 isoform 2
NM_001427352.1 NP_001414281.1 pleckstrin homology domain-containing family A member 2 isoform 2
NM_031257.4 NP_112547.1 pleckstrin homology domain-containing family A member 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
14516276 MGI
enables phosphatidylinositol-3,4-bisphosphate binding IDA
IDA: Inferred from direct assay
11001876 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11802782 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Plekha2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Plekha2 Q9ERS5 MPDZ Homo sapiens O75970
Pull Down
11802782
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10682 PLEKHA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10679 PLEKHA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10680 PLEKHA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10681 PLEKHA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10683 PLEKHA6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10684 PLEKHA7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10686 PLEKHB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10688 PLEKHF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10690 PLEKHG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10696 PLEKHH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10698 PLEKHM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10701 PLEKHO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plekha2 NCBI NCBI:59339