Thbd - thrombomodulin Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 83580

Summary

Predicted to enable calcium ion binding activity and transmembrane signaling receptor activity. Involved in response to X-ray; response to cAMP; and response to lipopolysaccharide. Located in apicolateral plasma membrane; extracellular space; and vacuolar membrane. Used to study acute kidney failure. Biomarker of adult respiratory distress syndrome; hypertension; ischemia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including acute kidney failure; atypical hemolytic-uremic syndrome; cerebrovascular disease (multiple); rheumatoid arthritis; and thrombophilia (multiple). Orthologous to human THBD (thrombomodulin). [provided by Alliance of Genome Resources, Apr 2022]

Thbd Products (1)

mRNA Protein Name
NM_031771.2 NP_113959.1 thrombomodulin precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in response to X-ray IEP
IEP: Inferred from expression pattern
12057911 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
17090405 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
12611420 RGD
Cellular Component GO Annotation Evidence References Source
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
9272431 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
12611420 RGD
located in vacuolar membrane IDA
IDA: Inferred from direct assay
9272431 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thrombomodulin

  • thrombomdulin

Recombinant Thbd Proteins

Cat. No. Product Name Accession Purity
HY-P74519 Thrombomodulin Protein, Rat (HEK293, His) O35370 (I17-S517) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14478 THBD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18261 Thbd Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24740 Thbd Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Thbd NCBI NCBI:7056