THBD - thrombomodulin Gene
Also Known as TM; THRM; AHUS6; BDCA3; CD141; BDCA-3; THPH12
Species: Homo sapiens
About THBD
This gene has 1 transcript (splice variant), 66 orthologues and is associated with 4 phenotypes.
Summary
The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds Thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of Thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. [provided by RefSeq, Jul 2008]
THBD Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_000361.3 | NP_000352.1 | thrombomodulin precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
14691232 | GOA |
| enables signaling receptor activity |
IDA
IDA: Inferred from direct assay
|
10761923 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in negative regulation of blood coagulation |
IDA
IDA: Inferred from direct assay
|
10761923 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
17379830 | GOA |
| is active in plasma membrane |
IDA
IDA: Inferred from direct assay
|
17379830 | GOA |
| part of serine-type endopeptidase complex |
IPI
IPI: Inferred from physical interaction
|
14691232 | GOA |
THBD Protein Structure
FXa_inhibition: Coagulation Factor Xa inhibitory site (245 - 280)
EGF_CA: Calcium-binding EGF domain (325 - 360)
Tme5_EGF_like: Thrombomodulin like fifth domain, EGF-like (406 - 439)
EGF_CA: Calcium-binding EGF domain (441 - 471)
- 0
- 100
- 200
- 300
- 400
- 500
- 575 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
thrombomodulin |
|
THBD Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
THBD | P07204 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
THBD | P07204 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
THBD | P07204 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
THBD | P07204 | TMEM35A | Homo sapiens | Q53FP2 | 32296183 | |
|
Intra
|
THBD | P07204 | TMEM35A | Homo sapiens | Q53FP2 | 32296183 | |
|
Intra
|
THBD | P07204 | TMEM35A | Homo sapiens | Q53FP2 | 32296183 | |
|
Intra
|
THBD | P07204 | AIG1 | Homo sapiens | Q9NVV5-2 | 32296183 | |
|
Intra
|
THBD | P07204 | AIG1 | Homo sapiens | Q9NVV5-2 | 32296183 | |
|
Intra
|
THBD | P07204 | AIG1 | Homo sapiens | Q9NVV5-2 | 32296183 | |
|
Intra
|
THBD | P07204 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
THBD | P07204 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
THBD | P07204 | AQP6 | Homo sapiens | Q13520 | 32296183 | |
|
Intra
|
THBD | P07204 | MUC1 | Homo sapiens | P15941-11 | 32296183 | |
|
Intra
|
THBD | P07204 | MUC1 | Homo sapiens | P15941-11 | 32296183 | |
|
Intra
|
THBD | P07204 | MUC1 | Homo sapiens | P15941-11 | 32296183 | |
|
Intra
|
THBD | P07204 | SLC35C2 | Homo sapiens | Q9NQQ7-3 | 32296183 | |
|
Intra
|
THBD | P07204 | SLC35C2 | Homo sapiens | Q9NQQ7-3 | 32296183 | |
|
Intra
|
THBD | P07204 | SLC35C2 | Homo sapiens | Q9NQQ7-3 | 32296183 | |
|
Intra
|
THBD | P07204 | RHBDD2 | Homo sapiens | Q6NTF9-3 | 32296183 | |
|
Intra
|
THBD | P07204 | RHBDD2 | Homo sapiens | Q6NTF9-3 | 32296183 | |
|
Intra
|
THBD | P07204 | RHBDD2 | Homo sapiens | Q6NTF9-3 | 32296183 | |
|
Intra
|
THBD | P07204 | PHF24 | Homo sapiens | Q9UPV7 | 32296183 | |
|
Intra
|
THBD | P07204 | APOC4 | Homo sapiens | P55056 | 32296183 | |
|
Intra
|
THBD | P07204 | APOC4 | Homo sapiens | P55056 | 32296183 | |
|
Intra
|
THBD | P07204 | APOC4 | Homo sapiens | P55056 | 32296183 | |
|
Intra
|
THBD | P07204 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
THBD | P07204 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
THBD | P07204 | FAM209A | Homo sapiens | Q5JX71 | 32296183 | |
|
Intra
|
THBD | P07204 | TMEM86B | Homo sapiens | Q8N661 | 32296183 | |
|
Intra
|
THBD | P07204 | TMEM86B | Homo sapiens | Q8N661 | 32296183 | |
|
Intra
|
THBD | P07204 | TMEM86B | Homo sapiens | Q8N661 | 32296183 | |
|
Intra
|
THBD | P07204 | CYBC1 | Homo sapiens | Q9BQA9 | 32296183 | |
|
Intra
|
THBD | P07204 | CYBC1 | Homo sapiens | Q9BQA9 | 32296183 | |
|
Intra
|
THBD | P07204 | CYBC1 | Homo sapiens | Q9BQA9 | 32296183 | |
|
Intra
|
THBD | P07204 | F2 | Homo sapiens | P00734 | 14691232 | |
|
Intra
|
THBD | P07204 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
THBD | P07204 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
THBD | P07204 | EBP | Homo sapiens | Q15125 | 32296183 | |
|
Intra
|
THBD | P07204 | MTIF3 | Homo sapiens | Q9H2K0 | 32296183 | |
|
Intra
|
THBD | P07204 | MTIF3 | Homo sapiens | Q9H2K0 | 32296183 | |
|
Intra
|
THBD | P07204 | MTIF3 | Homo sapiens | Q9H2K0 | 32296183 | |
|
Intra
|
THBD | P07204 | SLC19A3 | Homo sapiens | Q9BZV2 | 32296183 | |
|
Intra
|
THBD | P07204 | SLC19A3 | Homo sapiens | Q9BZV2 | 32296183 | |
|
Intra
|
THBD | P07204 | SLC19A3 | Homo sapiens | Q9BZV2 | 32296183 | |
|
Intra
|
THBD | P07204 | MMGT1 | Homo sapiens | Q8N4V1 | 32296183 | |
|
Intra
|
THBD | P07204 | MMGT1 | Homo sapiens | Q8N4V1 | 32296183 | |
|
Intra
|
THBD | P07204 | MMGT1 | Homo sapiens | Q8N4V1 | 32296183 | |
|
Intra
|
THBD | P07204 | TMX2 | Homo sapiens | Q9Y320 | 32296183 | |
|
Intra
|
THBD | P07204 | TMX2 | Homo sapiens | Q9Y320 | 32296183 | |
|
Intra
|
THBD | P07204 | TMX2 | Homo sapiens | Q9Y320 | 32296183 | |
|
Intra
|
THBD | P07204 | CIDEB | Homo sapiens | Q9UHD4 | 32296183 | |
|
Intra
|
THBD | P07204 | CIDEB | Homo sapiens | Q9UHD4 | 32296183 | |
|
Intra
|
THBD | P07204 | CIDEB | Homo sapiens | Q9UHD4 | 32296183 | |
|
Intra
|
THBD | P07204 | PDZK1IP1 | Homo sapiens | Q13113 | 32296183 | |
|
Intra
|
THBD | P07204 | PDZK1IP1 | Homo sapiens | Q13113 | 32296183 | |
|
Intra
|
THBD | P07204 | PDZK1IP1 | Homo sapiens | Q13113 | 32296183 | |
|
Intra
|
THBD | P07204 | CD79A | Homo sapiens | P11912 | 32296183 | |
|
Intra
|
THBD | P07204 | CD79A | Homo sapiens | P11912 | 32296183 | |
|
Intra
|
THBD | P07204 | CD79A | Homo sapiens | P11912 | 32296183 | |
|
Intra
|
THBD | P07204 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
THBD | P07204 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
THBD | P07204 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
THBD | P07204 | KIR2DL3 | Homo sapiens | P43628 | 32296183 | |
|
Intra
|
THBD | P07204 | KIR2DL3 | Homo sapiens | P43628 | 32296183 | |
|
Intra
|
THBD | P07204 | KIR2DL3 | Homo sapiens | P43628 | 32296183 | |
|
Intra
|
THBD | P07204 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
THBD | P07204 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 | |
|
Intra
|
THBD | P07204 | TMEM14B | Homo sapiens | Q9NUH8 | 32296183 |
Recombinant THBD Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70724 | Thrombomodulin Protein, Human (HEK293, His, solution) | P07204 (A19-S515) | ≥ 95%, as determined by reducing SDS-PAGE. |
THBD Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81045 | Thrombomodulin Antibody (YA891) | WB, ICC/IF, IP | Human |
| HY-P81045A | Thrombomodulin Antibody (YA891)(PBS only) | WB, ICC/IF, IP | Human |
| HY-P84964 | Thrombomodulin Antibody (YA4656) | ||
| HY-P85842 | Thrombomodulin Antibody (YA5534) | IHC-P, WB, ICC/IF, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Thrombophilia Due To Thrombomodulin Defect |
|
|
| Hemolytic Uremic Syndrome, Atypical 6 |
|
|
| D-Minus Hemolytic Uremic Syndrome |
|
|
| Hemolytic Uremic Syndrome, Atypical 1 |
|
|
| Atypical Hemolytic Uremic Syndrome With Complement Gene Abnormality |
|
|
| Thrombophilia |
|
|
| Thrombosis |
|
|
| Dengue Shock Syndrome |
|
|
| Disseminated Intravascular Coagulation |
|
|
| Eisenmenger Syndrome |
|
|
| Thrombotic Thrombocytopenic Purpura |
|
|
| Protein C Deficiency |
|
|
| Hepatic Veno-Occlusive Disease |
|
|
| Thrombocytopenia |
|
|
| Hemolytic-Uremic Syndrome |
|
|
| Churg-Strauss Syndrome |
|
|
| End Stage Renal Disease |
|
|
| Adult Respiratory Distress Syndrome |
|
|
| Benign Mesothelioma |
|
|
| Peripheral Vascular Disease |
|
|
| Antiphospholipid Syndrome |
|
|
| Erythromelalgia |
|
|
| Thrombophilia Due To Activated Protein C Resistance |
|
|
| Collagen Disease |
|
|
| Eclampsia |
|
|
| Hemorrhagic Disease |
|
|
| Pulmonary Hypertension |
|
|
| Adenomatoid Tumor |
|
|
| Vasculitis |
|
|
| Ovarian Brenner Tumor |
|
|
| Legg-Calve-Perthes Disease |
|
|
| Hyperhomocysteinemia |
|
|
| Essential Thrombocythemia |
|
|
| Protein S Deficiency |
|
|
| Factor Xi Deficiency |
|
|
| Myocardial Infarction |
|
|
| Purpura |
|
|
| Mercury Poisoning |
|
|
| Thrombophilia Due To Thrombin Defect |
|
|
| Pulmonary Embolism |
|
|
| Mesothelioma, Malignant |
|
|
| Vascular Disease |
|
|
| Hemoglobinuria |
|
|
| Polycythemia Vera |
|
|
| Pre-Eclampsia |
|
|
| Homocystinuria |
|
|
| Raynaud Disease |
|
|
| Sertoli-Leydig Cell Tumor |
|
|
| Stroke, Ischemic |
|
|
| Varicose Veins |
|
|
| Malignant Adenofibroma |
|
|
| Hellp Syndrome |
|
|
| Acute Myocardial Infarction |
|
|
| Asbestosis |
|
|
| Plasmodium Falciparum Malaria |
|
|
| Diabetic Angiopathy |
|
|
| Malignant Epithelial Mesothelioma |
|
|
| Acute Promyelocytic Leukemia |
|
|
| Boutonneuse Fever |
|
|
| Systemic Lupus Erythematosus |
|
|
| Arteriosclerosis |
|
|
| Takayasu Arteritis |
|
|
| Transitional Cell Carcinoma |
|
|
| Loeffler Endocarditis |
|
|
| Post-Cardiac Arrest Syndrome |
|
|
| Typhoid Fever |
|
|
| Cardiovascular System Disease |
|
|
| Purpura Fulminans |
|
|
| Atherosclerosis Susceptibility |
|
|
| Leukemia, Acute Monocytic |
|
|
| Lymphohistiocytoid Mesothelioma |
|
|
| Malaria |
|
|
| Viral Hepatitis |
|
|
| Blood Coagulation Disease |
|
|
| Hemolytic Anemia |
|
|
| Hypertension, Essential |
|
|
| Epididymis Adenocarcinoma |
|
|
| Dysfibrinogenemia, Congenital |
|
|
| Epididymis Cancer |
|
|
| Thymic Carcinoma |
|
|
| Kidney Disease |
|
|
| Complement Deficiency |
|
|
| Diabetes Mellitus |
|
|
| Pulmonary Artery Disease |
|
|
| Acute Cholangitis |
|
|
| Behcet Syndrome |
|
|
| Portal Vein Thrombosis |
|
|
| Post-Thrombotic Syndrome |
|
|
| Bladder Adenocarcinoma |
|
|
| Liver Fibroma |
|
|
| Large Cell Carcinoma |
|
|
| Heart Disease |
|
|
| Nephrogenic Adenoma Of The Urethra |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Alpha-2-Plasmin Inhibitor Deficiency |
|
|
| Meningococcemia |
|
|
| Myelofibrosis |
|
|
| Postaxial Acrofacial Dysostosis |
|
|
| Vein Disease |
|
|
| Hepatic Vascular Disease |
|
|
| Blood Platelet Disease |
|
|
| Autoimmune Disease Of Cardiovascular System |
|
|
| Membranoproliferative Glomerulonephritis |
|
|
| Myeloproliferative Neoplasm |
|
|
| Cerebral Palsy |
|
|
| Transvestism |
|
|
| Chronic Kidney Disease |
|
|
| Cardiomyopathy, Dilated, 1c, With Or Without Left Ventricular Noncompaction |
|
|
| Urethral Benign Neoplasm |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Inflammatory Bowel Disease |
|
|
| Respiratory Failure |
|
|
| Lung Cancer Susceptibility 3 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | THBD | RGD | RGD:621299 |
| Mus musculus | THBD | MGD | MGI:98736 |
| Felis catus | THBD | VGNC | VGNC:66153 |
| Canis familiaris | THBD | VGNC | VGNC:47334 |
| Macaca mulatta | THBD | VGNC | VGNC:78343 |
| Bos taurus | THBD | VGNC | VGNC:35827 |
| Others | THBD | NCBI |