Git1 - GIT ArfGAP 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 83709

Summary

Enables GTPase activator activity; identical protein binding activity; and small GTPase binding activity. A structural constituent of postsynaptic specialization. Involved in several processes, including cellular response to epidermal growth factor stimulus; neurotransmitter receptor localization to postsynaptic specialization membrane; and regulation of signal transduction. Acts upstream of or within dendritic spine development and immunological synapse formation. Located in several cellular components, including cytosol; endosome; and neuron projection. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynapse. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human GIT1 (GIT ArfGAP 1). [provided by Alliance of Genome Resources, Apr 2022]

Git1 Products (1)

mRNA	Protein	Name
NM_031814.2	NP_114002.1	ARF GTPase-activating protein GIT1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	9826657	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	15212761	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12473661	RGD
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	12629171	RGD
enables protein tyrosine kinase binding	IPI IPI: Inferred from physical interaction	12629171	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	12629171	RGD
enables small GTPase binding	IDA IDA: Inferred from direct assay	9826657	RGD
enables structural constituent of postsynaptic specialization	IDA IDA: Inferred from direct assay	25284783	RGD
enables structural constituent of postsynaptic specialization	IMP IMP: Inferred from mutant phenotype	25284783	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to epidermal growth factor stimulus	IDA IDA: Inferred from direct assay	18523162	RGD
acts upstream of or within dendritic spine development	IGI IGI: Inferred from genetic interaction	17310244	RGD
acts upstream of or within immunological synapse formation	IGI IGI: Inferred from genetic interaction	17310244	RGD
involved in negative regulation of ARF protein signal transduction	IDA IDA: Inferred from direct assay	16439353	RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	25284783	RGD
involved in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	25284783	RGD
involved in positive regulation of receptor catabolic process	IMP IMP: Inferred from mutant phenotype	18523162	RGD
involved in regulation of G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	9826657	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	25284783	RGD
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	25284783	RGD
located in dendrite	IDA IDA: Inferred from direct assay	12629171	RGD
located in endosome	IDA IDA: Inferred from direct assay	18523162	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	12629171	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	25284783	RGD
located in growth cone	IDA IDA: Inferred from direct assay	12629171	RGD
located in inhibitory synapse	IDA IDA: Inferred from direct assay	12629171	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	25284783	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ARF GTPase-activating protein GIT1	ARF GAP GIT1 CAT-1 CAT1 G protein-coupled receptor kinase interacting ArfGAP 1 G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein (GIT1) G protein-coupled receptor kinase-interactor 1 GRK-interacting prote

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152095	PPI-GIT1/β-Pix PPI-IN-1	Inhibitor	99.01%	Unkown
HY-181978	GIT1-IN-1		/	Unkown
HY-RS05438	GIT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19605	Git1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26101	Git1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Git1	NCBI	NCBI:28964