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Rps6kb1 - ribosomal protein S6 kinase B1 Gene

Also Known as p70 S6K-alpha

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 83840

About Rps6kb1

Primary_assembly 10: 71,323,777-71,367,908 reverse strand.mRatBN7.2:CM026983.1

This gene has 3 transcripts (splice variants), 155 orthologues, 7 paralogues and is associated with 17 phenotypes. Biased expression in Muscle (RPKM 16.2), Thymus (RPKM 146.) and 9 other tissues.

Summary

Enables several functions, including ATP binding activity; PDZ domain binding activity; and protein Phosphatase 2A binding activity. Involved in several processes, including long-term memory; positive regulation of skeletal muscle tissue growth; and response to peptide hormone. Located in several cellular components, including cell surface; cytosol; and perinuclear region of cytoplasm. Is active in synapse. Biomarker of several diseases, including autosomal dominant polycystic kidney disease; hyperinsulinism; muscular atrophy; obesity; and primary biliary cholangitis. Orthologous to human RPS6KB1 (ribosomal protein S6 kinase B1). [provided by Alliance of Genome Resources, Apr 2022]

Rps6kb1 Products (1)

mRNA	Protein	Name
NM_031985.1	NP_114191.1	ribosomal protein S6 kinase beta-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	11574531	RGD
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	9653190	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	17446865	RGD
enables peptide binding	IDA IDA: Inferred from direct assay	11574531	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9653190	RGD
enables protein kinase activity	IDA IDA: Inferred from direct assay	11574531	RGD
enables protein phosphatase 2A binding	IPI IPI: Inferred from physical interaction	16899564	RGD
enables ribosomal protein S6 kinase activity	IMP IMP: Inferred from mutant phenotype	11574531	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cell migration	IEP IEP: Inferred from expression pattern	16710051	RGD
involved in cellular response to hormone stimulus	IEP IEP: Inferred from expression pattern	16717100	RGD
involved in long-term memory	IEP IEP: Inferred from expression pattern	16885218	RGD
involved in negative regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18952604	RGD
involved in positive regulation of skeletal muscle tissue growth	IMP IMP: Inferred from mutant phenotype	16408196	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	16148030	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	16148030	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11574531	RGD
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	9653190	RGD
involved in regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	18952604	RGD
involved in response to L-leucine	IEP IEP: Inferred from expression pattern	16616211	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	10913029	RGD
involved in response to electrical stimulus involved in regulation of muscle adaptation	IEP IEP: Inferred from expression pattern	15716393	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	15547464	RGD
involved in response to glucagon	IEP IEP: Inferred from expression pattern	15494402	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	14630710	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	16885218	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	15908181	RGD
involved in response to insulin	IMP IMP: Inferred from mutant phenotype	18952604	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	15389631	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	17526558	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	10913029	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16616211	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	12668683	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	15698549	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	15342961	RGD
involved in response to tumor necrosis factor	IMP IMP: Inferred from mutant phenotype	18952604	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17728140	RGD
involved in skeletal muscle atrophy	IEP IEP: Inferred from expression pattern	17885021	RGD
involved in skeletal muscle contraction	IEP IEP: Inferred from expression pattern	15033970	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	16710051	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16710051	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	14623952	RGD
is active in synapse	IDA IDA: Inferred from direct assay	12711090	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rps6kb1 Protein Structure

STKc_p70S6K

0
100
200
300
400
500
525 a.a.

Protein Preferred Names	Protein Names
ribosomal protein S6 kinase beta-1	70 kDa ribosomal protein S6 kinase 1 P70S6K P70S6K1 S6 kinase S6K S6K-beta-1 S6K1 p70 S6 kinase alpha p70 S6KA p70 ribosomal S6 kinase alpha p70(S6K)-alpha p70-S6K 1 ribosomal protein S6 kinase I ribosomal protein S6 kinase, 70kDa, polypeptide 1 ribosomal protein S6 kinase, polypeptide 1

Rps6kb1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Rps6kb1	P67999	RPTOR	Homo sapiens	Q8N122	Pull Down	12150926
Intra	Rps6kb1	P67999	Ppp1r9a	Rattus norvegicus	O35867	Pull Down	9653190
Intra	Rps6kb1	P67999	Pdk1	Rattus norvegicus	Q63065	Protein Kinase Assay	17446865
Intra	Rps6kb1	P67999	Rps6kb1	Rattus norvegicus	P67999	Protein Kinase Assay	17446865
Intra	Rps6kb1	P67999	Rps6	Mus musculus	P62754	Protein Kinase Assay	21986499
Intra	Rps6kb1	P67999	Mtor	Mus musculus	Q9JLN9	Protein Kinase Assay	12150926
Intra	Rps6kb1	P67999	Ppp1r9a	Rattus norvegicus	O35867	Anti Tag CoIP	9653190
Intra	Rps6kb1	P67999	Coasy	Rattus norvegicus	Q5XIA5	GMS	15589845
Intra	Rps6kb1	P67999	Rps6kb1	Rattus norvegicus	P67999	Protein Kinase Assay	21986499

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148062	RSS0680	Degrader	98.03%	Unkown
HY-RS12262	RPS6KB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12263	Rps6kb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS12264	Rps6kb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rps6kb1	NCBI	NCBI:6198