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Ppp1r9a - protein phosphatase 1, regulatory subunit 9A Gene

Also Known as Neb1; p180; PP1bp175

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 84685

Summary

Enables several functions, including enzyme binding activity; protein C-terminus binding activity; and transmembrane transporter binding activity. Involved in several processes, including modulation of chemical synaptic transmission; regulation of actin filament organization; and regulation of synapse organization. Acts upstream of or within neuron projection development. Located in several cellular components, including dendritic spine neck; growth cone lamellipodium; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic actin Cytoskeleton. Used to study transient cerebral ischemia. Biomarker of hepatocellular carcinoma. Orthologous to human PPP1R9A (protein Phosphatase 1 regulatory subunit 9A). [provided by Alliance of Genome Resources, Apr 2022]

Ppp1r9a Products (2)

mRNA	Protein	Name
NM_001401497.1	NP_001388426.1	neurabin-1 isoform 1
NM_053473.3	NP_445925.1	neurabin-1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GTPase binding	IDA IDA: Inferred from direct assay	16525025	RGD
enables actin filament binding	IDA IDA: Inferred from direct assay	9362513	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	9362513	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9653190	RGD
enables protein domain specific binding	IDA IDA: Inferred from direct assay	10514494	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	9653190	RGD
enables protein phosphatase 1 binding	IDA IDA: Inferred from direct assay	16899074	RGD
enables protein phosphatase 1 binding	IPI IPI: Inferred from physical interaction	9282913	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	10504266	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	16025302	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to toxic substance	IDA IDA: Inferred from direct assay	12052877	RGD
involved in excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	15473970	RGD
involved in negative regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	16899074	RGD
involved in negative regulation of spontaneous neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	16899074	RGD
involved in negative regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	12052877	RGD
involved in neuron development	IEP IEP: Inferred from expression pattern	9362513	RGD
acts upstream of or within neuron projection development	IDA IDA: Inferred from direct assay	16525025	RGD
involved in positive regulation of dendritic spine development	IMP IMP: Inferred from mutant phenotype	12052877	RGD
involved in positive regulation of long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	16899074	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	9362513	RGD
involved in positive regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	9653190	RGD
involved in postsynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	15473970	RGD
involved in postsynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	15473970	RGD
involved in regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	15473970	RGD
involved in regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	15473970	RGD
involved in regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	12052877	RGD
involved in regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	15473970	RGD
involved in regulation of synapse structural plasticity	IMP IMP: Inferred from mutant phenotype	15473970	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	10514494	RGD
located in cytoskeleton	IDA IDA: Inferred from direct assay	16525025	RGD
located in dendrite	IDA IDA: Inferred from direct assay	9362513	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	15473970	RGD
located in dendritic spine neck	IDA IDA: Inferred from direct assay	15473970	RGD
located in filopodium	IDA IDA: Inferred from direct assay	15473970	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	15473970	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	15473970	RGD
located in growth cone	IDA IDA: Inferred from direct assay	16525025	RGD
located in growth cone lamellipodium	IDA IDA: Inferred from direct assay	9362513	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	9362513	RGD
located in neuromuscular junction	IDA IDA: Inferred from direct assay	9362513	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	9362513	RGD
is active in postsynaptic actin cytoskeleton	IDA IDA: Inferred from direct assay	15473970	RGD
is active in postsynaptic actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	15473970	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
neurabin-1	actin-binding protein neurabin neurabin-I neural tissue-specific F-actin-binding protein I protein phosphatase 1, regulatory (inhibitor) subunit 9A

Ppp1r9a Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Ppp1r9a	O35867	Rps6kb1	Rattus norvegicus	P67999	Y2H	9653190
Intra	Ppp1r9a	O35867	Ppp1cb	Rattus norvegicus	P62142	Pull Down	18216290
Intra	Ppp1r9a	O35867	Ppp1cc	Rattus norvegicus	P63088	Pull Down	18216290
Intra	Ppp1r9a	O35867	Ppp1cc	Rattus norvegicus	P63088	Anti Tag CoIP	18216290

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11005	PPP1R9A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21250	Ppp1r9a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27767	Ppp1r9a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ppp1r9a	NCBI	NCBI:55607