NCALD - neurocalcin delta Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83988

About NCALD

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:101,686,542-102,124,907 (from NCBI)

This gene has 30 transcripts (splice variants), 211 orthologues and 14 paralogues. Broad expression in brain (RPKM 22.6), salivary gland (RPKM 11.3) and 20 other tissues.

Summary

This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

NCALD Products (8)

mRNA Protein Name
NM_001040624.2 NP_001035714.1 neurocalcin-delta
NM_001040625.2 NP_001035715.1 neurocalcin-delta
NM_001040626.2 NP_001035716.1 neurocalcin-delta
NM_001040627.2 NP_001035717.1 neurocalcin-delta
NM_001040628.2 NP_001035718.1 neurocalcin-delta
NM_001040629.2 NP_001035719.1 neurocalcin-delta
NM_001040630.2 NP_001035720.1 neurocalcin-delta
NM_032041.3 NP_114430.2 neurocalcin-delta

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
11964161 GOA
enables clathrin binding IDA
IDA: Inferred from direct assay
11964161 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables tubulin binding IDA
IDA: Inferred from direct assay
11964161 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCALD Protein Structure

EF-hand_1

EF-hand_1: EF hand (66 - 90)

EF-hand_7

EF-hand_7: EF-hand domain pair (100 - 171)

  • 0
  • 100
  • 193 a.a.
Protein Preferred Names Protein Names

neurocalcin-delta

NCALD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NCALD P61601 LCE2D Homo sapiens Q5TA82
Validated Y2H
32296183
Intra
NCALD P61601 LCE2D Homo sapiens Q5TA82
Y2H Array
32296183
Intra
NCALD P61601 LCE2D Homo sapiens Q5TA82
Y2H Prey Pooling
32296183
Intra
NCALD P61601 LIF Homo sapiens P15018
Y2H Prey Pooling
32296183
Intra
NCALD P61601 LIF Homo sapiens P15018
Y2H Array
32296183
Intra
NCALD P61601 FGF6 Homo sapiens P10767
Y2H Prey Pooling
32296183
Intra
NCALD P61601 FGF6 Homo sapiens P10767
Y2H Array
32296183
Intra
NCALD P61601 MIEF2 Homo sapiens Q96C03-3
Validated Y2H
32296183
Intra
NCALD P61601 C19orf44 Homo sapiens Q9H6X5-2
Y2H Array
32296183
Intra
NCALD P61601 C19orf44 Homo sapiens Q9H6X5-2
Y2H Prey Pooling
32296183
Intra
NCALD P61601 C19orf44 Homo sapiens Q9H6X5-2
Validated Y2H
32296183
Intra
NCALD P61601 PLAAT2 Homo sapiens Q9NWW9
Validated Y2H
32296183
Intra
NCALD P61601 PLAAT2 Homo sapiens Q9NWW9
Y2H Array
32296183
Intra
NCALD P61601 LY6G6D Homo sapiens O95868
Y2H Prey Pooling
32296183
Intra
NCALD P61601 LY6G6D Homo sapiens O95868
Y2H Array
32296183
Intra
NCALD P61601 MLLT10 Homo sapiens P55197-2
Y2H Array
32296183
Intra
NCALD P61601 MLLT10 Homo sapiens P55197-2
Y2H Prey Pooling
32296183
Intra
NCALD P61601 CREM Homo sapiens Q03060-25
Y2H Prey Pooling
32296183
Intra
NCALD P61601 CREM Homo sapiens Q03060-25
Validated Y2H
32296183
Intra
NCALD P61601 CREM Homo sapiens Q03060-25
Y2H Array
32296183
Intra
NCALD P61601 TPSG1 Homo sapiens Q9NRR2
Validated Y2H
32296183
Intra
NCALD P61601 SBSN Homo sapiens Q6UWP8-2
Validated Y2H
32296183
Intra
NCALD P61601 SBSN Homo sapiens Q6UWP8-2
Y2H Array
32296183
Intra
NCALD P61601 SBSN Homo sapiens Q6UWP8-2
Y2H Prey Pooling
32296183
Intra
NCALD P61601 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Prey Pooling
25416956
Intra
NCALD P61601 C1QTNF2 Homo sapiens Q9BXJ5
Validated Y2H
25416956
Intra
NCALD P61601 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Prey Pooling
32296183
Intra
NCALD P61601 C1QTNF2 Homo sapiens Q9BXJ5
Validated Y2H
32296183
Intra
NCALD P61601 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Array
25416956
Intra
NCALD P61601 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Array
32296183
Intra
NCALD P61601 GOLGA7 Homo sapiens Q7Z5G4
Validated Y2H
32296183
Intra
NCALD P61601 GOLGA7 Homo sapiens Q7Z5G4
Y2H Array
32296183
Intra
NCALD P61601 GOLGA7 Homo sapiens Q7Z5G4
Y2H Prey Pooling
32296183
Intra
NCALD P61601 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
NCALD P61601 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
NCALD P61601 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32296183
Intra
NCALD P61601 SPRED1 Homo sapiens Q7Z699
Y2H Prey Pooling
32296183
Intra
NCALD P61601 SPRED1 Homo sapiens Q7Z699
Y2H Array
32296183
Intra
NCALD P61601 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
NCALD P61601 ANOS1 Homo sapiens P23352
Y2H Array
32296183
Intra
NCALD P61601 ANOS1 Homo sapiens P23352
Y2H Prey Pooling
32296183
Cross
NCALD P61601 tir Escherichia coli O157:H7 Q7DB77
Y2H
25519916
Intra
NCALD P61601 MYDGF Homo sapiens Q969H8
Validated Y2H
32296183
Intra
NCALD P61601 LITAF Homo sapiens Q99732
Validated Y2H
32296183
Intra
NCALD P61601 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
25416956
Intra
NCALD P61601 DTX2 Homo sapiens Q86UW9
Y2H
21516116
Intra
NCALD P61601 DTX2 Homo sapiens Q86UW9
Y2H Pooling
16189514
Intra
NCALD P61601 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra
NCALD P61601 GPX7 Homo sapiens Q96SL4
Validated Y2H
32296183
Intra
NCALD P61601 GPX7 Homo sapiens Q96SL4
Y2H Array
32296183
Intra
NCALD P61601 GPX7 Homo sapiens Q96SL4
Y2H Prey Pooling
32296183
Intra
NCALD P61601 IGFBP6 Homo sapiens P24592
Y2H Prey Pooling
32296183
Intra
NCALD P61601 IGFBP6 Homo sapiens P24592
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NCALD Proteins

Cat. No. Product Name Accession Purity
HY-P70389 Neurocalcin-delta/NCALD Protein, Human (His) P61601 (M1-F193) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Childhood Spinal Muscular Atrophy

  • Spinal Muscular Atrophies Of Childhood

  • Survival Motor Neuron Spinal Muscular Atrophy
Spinal Muscular Atrophy, Type I

  • Werdnig-Hoffmann Disease

  • SMA1

  • Spinal Muscular Atrophy 1

  • Sma I

  • Sma, Infantile Acute Form

  • Muscular Atrophy, Infantile

  • Spinal Muscular Atrophy-1

  • Hmn Proximal Type I

  • Infantile Muscular Atrophy

  • Proximal Spinal Muscular Atrophy Type 1

  • Sma Type 1

  • Sma Type I

  • Sma-I

  • Hereditary Motor Neuropathy Proximal Type I

  • Progressive Muscular Atrophy Of Infancy

  • Proximal Spinal Muscular Atrophy, Type 1

  • Werdnig Hoffmann Disease

  • Infantile Spinal Muscular Atrophy

  • Infantile-Onset Spinal Muscular Atrophy

  • Proximal Hereditary Motor Neuropathy Type I

  • Sma Infantile Acute Form

  • Spinal Muscular Atrophy Type I

  • Werdnig-Hoffman Disease

  • Atrophy, Muscular, Spinal, Type 1
Spinal Muscular Atrophy, Type Iii

  • SMA3

  • Juvenile Spinal Muscular Atrophy

  • Kugelberg-Welander Disease

  • Sma Iii

  • Kugelberg-Welander Syndrome

  • Kws

  • Muscular Atrophy, Juvenile

  • Spinal Muscular Atrophy, Mild Childhood And Adolescent Form

  • Spinal Muscular Atrophy-3

  • Spinal Muscular Atrophy Type 3

  • Spinal Muscular Atrophy, Type Iii, Modifier Of

  • Type Iii Spinal Muscular Atrophy

  • Sma 3

  • Proximal Spinal Muscular Atrophy Type 3

  • Sma Type 3

  • Sma Type Iii

  • Sma-Iii

  • Spinal Muscular Atrophy 3

  • Spinal Muscular Atrophy Mild Childhood And Adolescent Form

  • Spinal Muscular Atrophy Type Iii

  • Wohlfart-Kugelberg-Welander Disease

  • Atrophy, Muscular, Spinal, Type Iii
Dubowitz Syndrome

  • Dubowitz'S Syndrome

  • Dwarfism-Eczema-Peculiar Facies Syndrome

  • Intrauterine Growth Restriction, Short Stature, Microcephaly, Mild Intellectual Disability With Behavior Problems, Eczema, And Unusual And Distinctive Faci
Muscular Atrophy

  • Muscle Wasting

  • Amyotrophia

  • Wasting - Muscle

  • Skeletal Muscle Atrophy
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09062 NCALD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20450 Ncald Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26959 Ncald Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NCALD RGD RGD:1560287
Bos taurus NCALD VGNC VGNC:31897
Macaca mulatta NCALD VGNC VGNC:75135
Mus musculus NCALD MGD MGI:1196326
Canis familiaris NCALD VGNC VGNC:43635
Felis catus NCALD VGNC VGNC:68420
Others NCALD NCBI