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MAF1 - MAF1 homolog, negative regulator of RNA polymerase III Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84232

About MAF1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,104,461-144,107,611 (from NCBI)

This gene has 6 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in fat (RPKM 39.1), ovary (RPKM 34.7) and 25 other tissues.

Summary

This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008]

MAF1 Products (1)

mRNA	Protein	Name
NM_032272.5	NP_115648.2	repressor of RNA polymerase III transcription MAF1 homolog

MAF1 Protein Structure

Maf1

0
100
200
256 a.a.

Protein Preferred Names	Protein Names
repressor of RNA polymerase III transcription MAF1 homolog	MAF1 negative regulator of RNA polymerase III

MAF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MAF1	Q9H063	ARMCX3	Homo sapiens	Q9UH62	Anti Tag CoIP	33961781
Intra	MAF1	Q9H063	ARMCX3	Homo sapiens	Q9UH62	Y2H Array	19060904
Intra	MAF1	Q9H063	ARMCX3	Homo sapiens	Q9UH62	Anti Tag CoIP	28514442
Intra	MAF1	Q9H063	ARMCX3	Homo sapiens	Q9UH62	Y2H Pooling	19060904
Intra	MAF1	Q9H063	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	MAF1	Q9H063	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	MAF1	Q9H063	WFS1	Homo sapiens	O76024	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Hypomyelinating Leukodystrophy	Hld Leukodystrophy, Hypomyelinating

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07957	MAF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MAF1	VGNC	VGNC:63363
Rattus norvegicus	MAF1	RGD	RGD:1359315
Bos taurus	MAF1	VGNC	VGNC:31137
Mus musculus	MAF1	MGD	MGI:1916127
Others	MAF1	NCBI