ELOF1 - elongation factor 1 Gene

Also Known as ELF1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84337

About ELOF1

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:11,553,046-11,559,230 (from NCBI)

This gene has 9 transcripts (splice variants) and 203 orthologues. Broad expression in testis (RPKM 39.1), prostate (RPKM 12.1) and 25 other tissues.

Summary

Predicted to enable RNA polymerase II complex binding activity. Predicted to be involved in epigenetic maintenance of chromatin in transcription-competent conformation and transcription elongation from RNA polymerase II promoter. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Apr 2022]

ELOF1 Products (4)

mRNA Protein Name
NM_001363673.3 NP_001350602.2 transcription elongation factor 1 homolog
NM_001363674.4 NP_001350603.2 transcription elongation factor 1 homolog
NM_001363675.4 NP_001350604.2 transcription elongation factor 1 homolog
NM_032377.4 NP_115753.1 transcription elongation factor 1 homolog

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELOF1 Protein Structure

Elf1

Elf1: Transcription elongation factor Elf1 like (2 - 82)

  • 0
  • 83 a.a.
Protein Preferred Names Protein Names

transcription elongation factor 1 homolog

  • ELF1 homolog, elongation factor 1

ELOF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ELOF1 P60002 C5orf22 Homo sapiens Q49AR2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spondyloepimetaphyseal Dysplasia With Joint Laxity, Type 2

  • SEMDJL2

  • Spondyloepimetaphyseal Dysplasia With Joint Laxity, Leptodactylic Type

  • Spondyloepimetaphyseal Dysplasia With Multiple Dislocations, Hall Type

  • Spondyloepimetaphyseal Dysplasia With Joint Laxity Type 2

  • Spondyloepimetaphyseal Dysplasia With Multiple Dislocations Hall Type

  • Spondyloepimetaphyseal Dysplasia With Joint Laxity, Hall Type

  • Semd-Md

  • Spondyloepimetaphyseal Dysplasia With Joint Laxicity, Hall Type

  • Spondyloepimetaphyseal Dysplasia With Joint Laxity, 2

  • Lepto-Semdjl

  • Spondyloepimetaphyseal Dysplasia With Joint Laxity Hall Type

  • Spondyloepimetaphyseal Dysplasia With Joint Laxity Leptodactylic Type

  • Spondyloepimetaphyseal Dysplasia With Multiple Dislocations
Gnathomiasis

  • Gnathostomiasis

  • Infectious Disease By Gnathostoma

  • Gnathostomosis

  • Wandering Swelling
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138794 XL177A Inhibitor 99.60% Unkown
HY-138794A (Rac)-XL177A Inhibitor / Unkown
HY-138794G XL177A (GMP) Inhibitor / Unkown
HY-RS04320 ELOF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ELOF1 MGD MGI:1913376
Canis familiaris ELOF1 VGNC VGNC:40318
Macaca mulatta ELOF1 VGNC VGNC:72132
Bos taurus ELOF1 VGNC VGNC:28446
Felis catus ELOF1 VGNC VGNC:61822
Rattus norvegicus ELOF1 RGD RGD:1587399
Others ELOF1 NCBI