2. Gene
  3. HDGFL2 - HDGF like 2 Gene

HDGFL2 - HDGF like 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HRP2; HDGF2; HRP-2; HDGF-2; HDGFRP2

Gene ID: 84717 | Gene type: protein coding

About HDGFL2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,472,297-4,502,207 (from NCBI)

This gene has 10 transcripts (splice variants), 220 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 20.4), brain (RPKM 10.1) and 25 other tissues.

Summary

This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

HDGFL2 Products(3)

mRNA Protein Name
NM_001001520.3 NP_001001520.1 hepatoma-derived growth factor-related protein 2 isoform 1
NM_001348169.2 NP_001335098.1 hepatoma-derived growth factor-related protein 2 isoform 3
NM_032631.4 NP_116020.1 hepatoma-derived growth factor-related protein 2 isoform 2
Protein Preferred Names Protein Names

hepatoma-derived growth factor-related protein 2

HDGF-related protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06095 HDGFL2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HDGFL2 VGNC VGNC:109500
Felis catus HDGFL2 VGNC VGNC:102608
Canis familiaris HDGFL2 VGNC VGNC:81269
Rattus norvegicus HDGFL2 RGD RGD:621013
Bos taurus HDGFL2 VGNC VGNC:109383
Mus musculus HDGFL2 MGD MGI:1194492