HDGFL2 - HDGF like 2 Gene

Also Known as HRP2; HDGF2; HRP-2; HDGF-2; HDGFRP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84717

About HDGFL2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,472,297-4,502,207 (from NCBI)

This gene has 10 transcripts (splice variants), 220 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 20.4), brain (RPKM 10.1) and 25 other tissues.

Summary

This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

HDGFL2 Products (3)

mRNA Protein Name
NM_001001520.3 NP_001001520.1 hepatoma-derived growth factor-related protein 2 isoform 1
NM_001348169.2 NP_001335098.1 hepatoma-derived growth factor-related protein 2 isoform 3
NM_032631.4 NP_116020.1 hepatoma-derived growth factor-related protein 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables H3K27me3 modified histone binding IDA
IDA: Inferred from direct assay
26721387 GOA
enables H3K9me3 modified histone binding IDA
IDA: Inferred from direct assay
26721387 GOA
enables histone reader activity IDA
IDA: Inferred from direct assay
26721387 GOA
enables methylated histone binding IMP
IMP: Inferred from mutant phenotype
32459350 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA repair-dependent chromatin remodeling IMP
IMP: Inferred from mutant phenotype
26721387 GOA
involved in muscle cell differentiation IMP
IMP: Inferred from mutant phenotype
32459350 GOA
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
25689719 GOA
involved in positive regulation of double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
26721387 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
26721387 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatoma-derived growth factor-related protein 2

  • HDGF-related protein 2

HDGFL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HDGFL2 Q7Z4V5 TERF2 Homo sapiens Q15554
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06095 HDGFL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta HDGFL2 VGNC VGNC:109500
Felis catus HDGFL2 VGNC VGNC:102608
Canis familiaris HDGFL2 VGNC VGNC:81269
Rattus norvegicus HDGFL2 RGD RGD:621013
Bos taurus HDGFL2 VGNC VGNC:109383
Mus musculus HDGFL2 MGD MGI:1194492
Others HDGFL2 NCBI