PLCD4 - phospholipase C delta 4 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84812

About PLCD4

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,607,899-218,637,175 (from NCBI)

This gene has 15 transcripts (splice variants), 294 orthologues and 14 paralogues. Broad expression in esophagus (RPKM 2.6), testis (RPKM 2.2) and 23 other tissues.

Summary

This gene encodes a member of the delta class of Phospholipase C enzymes. Phospholipase C enzymes play a critical role in many cellular processes by hydrolyzing phosphatidylinositol 4,5-bisphosphate into two intracellular second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. Expression of this gene may be a marker for Cancer. [provided by RefSeq, Jan 2011]

PLCD4 Products (1)

mRNA Protein Name
NM_032726.4 NP_116115.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G-protein alpha-subunit binding IPI
IPI: Inferred from physical interaction
30194280 GOA
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
30194280 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in small GTPase-mediated signal transduction IDA
IDA: Inferred from direct assay
30194280 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLCD4 Protein Structure

EF-hand_10

EF-hand_10: EF hand (153 - 203)

EF-hand_like

EF-hand_like: Phosphoinositide-specific phospholipase C, efhand-like (207 - 289)

PI-PLC-X

PI-PLC-X: Phosphatidylinositol-specific phospholipase C, X domain (292 - 436)

PI-PLC-Y

PI-PLC-Y: Phosphatidylinositol-specific phospholipase C, Y domain (493 - 609)

C2

C2: C2 domain (630 - 718)

  • 0
  • 200
  • 400
  • 600
  • 762 a.a.
Protein Preferred Names Protein Names

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4

  • PLC delta4

PLCD4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLCD4 Q9BRC7 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
PLCD4 Q9BRC7 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
PLCD4 Q9BRC7 MEOX1 Homo sapiens P50221
Y2H Array
32296183
Intra
PLCD4 Q9BRC7 MEOX1 Homo sapiens P50221
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Colorectal Cancer, Hereditary Nonpolyposis, Type 4

  • HNPCC4

  • Hereditary Nonpolyposis Colorectal Cancer Type 4

  • Hereditary Non-Polyposis Colorectal Cancer 4

  • Cancer, Colorectal, Nonpolyposis, Hereditary, Type 4
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10658 PLCD4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PLCD4 MGD MGI:107469
Bos taurus PLCD4 VGNC VGNC:32986
Canis familiaris PLCD4 VGNC VGNC:44649
Felis catus PLCD4 VGNC VGNC:68898
Rattus norvegicus PLCD4 RGD RGD:621025
Macaca mulatta PLCD4 VGNC VGNC:76167
Others PLCD4 NCBI