CDC14A - cell division cycle 14A Gene

Also Known as cdc14; DFNB32; DFNB35; hCDC14; DFNB105

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8556

About CDC14A

Cytogenetic location: 1p21.2 Genomic coordinates (GRCh38): 1:100,345,001-100,520,277 (from NCBI)

This gene has 14 transcripts (splice variants), 263 orthologues, 8 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 5.6), bone marrow (RPKM 3.3) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the dual specificity protein tyrosine Phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine Phosphatase involved in the exit of cell Mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

CDC14A Products (6)

mRNA	Protein	Name
NM_001319210.2	NP_001306139.1	dual specificity protein phosphatase CDC14A isoform 4
NM_001319211.2	NP_001306140.1	dual specificity protein phosphatase CDC14A isoform 5
NM_001319212.2	NP_001306141.1	dual specificity protein phosphatase CDC14A isoform 6
NM_003672.4	NP_003663.2	dual specificity protein phosphatase CDC14A isoform 1
NM_033312.3	NP_201569.1	dual specificity protein phosphatase CDC14A isoform 2
NM_033313.3	NP_201570.1	dual specificity protein phosphatase CDC14A isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16221885	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	29293958	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC14A Protein Structure

DSPn

DSPc

0
100
200
300
400
500
594 a.a.

Protein Preferred Names	Protein Names
dual specificity protein phosphatase CDC14A	CDC10 (cell division cycle 10, S. cerevisiae, homolog)

CDC14A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDC14A	Q9UNH5	ATPAF2	Homo sapiens	Q8N5M1	Validated Y2H	32296183
Intra	CDC14A	Q9UNH5	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 32, With Or Without Immotile Sperm	DFNB32 Hearing Impairment Infertile Male Syndrome Hiims Deafness, Autosomal Recessive 105, Formerly Dfnb105, Formerly Deafness, Autosomal Recessive, 32, With Or Without Immotile Sperm Deafness, Autosomal Recessive 105 Hearing Impairment And Infertile Male Syndrome
Autosomal Recessive Nonsyndromic Deafness 32	Deafness, Autosomal Recessive 32 Autosomal Recessive Deafness 105 Autosomal Recessive Deafness 32 Dfnb32 Hearing Impairment Infertile Male Syndrome Hiims Deafness, Autosomal Recessive, Type 32
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb	Autosomal Recessive Isolated Neurosensory Deafness Type Dfnb Autosomal Recessive Isolated Neurosensory Hearing Loss Type Dfnb Autosomal Recessive Isolated Sensorineural Deafness Type Dfnb Autosomal Recessive Isolated Sensorineural Hearing Loss Type Dfnb Autosomal Recessive Non-Syndromic Neurosensory Deafness Type Dfnb Autosomal Recessive Non-Syndromic Neurosensory Hearing Loss Type Dfnb Autosomal Recessive Non-Syndromic Sensorineural Hearing Loss Type Dfnb
Ear Malformation	Cup Ear
Rare Genetic Deafness	Rare Genetic Hearing Loss
Spermatogenic Failure 21	SPGF21
Myopathy, Centronuclear, 2	Myopathy, Centronuclear, Autosomal Recessive Autosomal Recessive Centronuclear Myopathy CNM2 Centronuclear Myopathy 2 Ar-Cnm Myotubular Myopathy, Autosomal Recessive Autosomal Recessive Myotubular Myopathy Centronuclear Myopathy Autosomal Recessive Myopathy, Centronuclear, Type 2
Pulmonary Immaturity	Primary Atelectasis Of Newborn Primary Atelectasis, In Perinatal Period Primary Failure To Expand Terminal Respiratory Units Immature Lungs Primary Atelectasis Pulmonary Immaturity Nos Lung Lobe Hypoplasia, Associated With Short Gestation Lung Nonexpansion Premature Lungs Pulmonary Hypoplasia Associated With Short Gestation Failure Of Expansion Of Terminal Respiratory Units Primary Atelectasis Of Fetus Or Newborn Primary Atelectasis In Perinatal Period

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-161673	CDC14A/B-IN-1	Inhibitor	/	Unkown
HY-206735	CDC14A/B-IN-2	Inhibitor	/	Unkown
HY-RS02285	CDC14A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CDC14A	VGNC	VGNC:27059
Rattus norvegicus	CDC14A	RGD	RGD:1304649
Felis catus	CDC14A	VGNC	VGNC:60647
Macaca mulatta	CDC14A	VGNC	VGNC:70791
Mus musculus	CDC14A	MGD	MGI:2442676
Canis familiaris	CDC14A	VGNC	VGNC:38986
Others	CDC14A	NCBI