PDLIM4 - PDZ and LIM domain 4 Gene

Also Known as RIL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8572

About PDLIM4

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:132,257,696-132,273,454 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues, 7 paralogues and is associated with 1 phenotype. Ubiquitous expression in endometrium (RPKM 8.6), prostate (RPKM 6.1) and 21 other tissues.

Summary

This gene encodes a protein which may be involved in bone development. Mutations in this gene are associated with susceptibility to osteoporosis. [provided by RefSeq, Nov 2009]

PDLIM4 Products (2)

mRNA	Protein	Name
NM_001131027.2	NP_001124499.1	PDZ and LIM domain protein 4 isoform 2
NM_003687.4	NP_003678.2	PDZ and LIM domain protein 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables alpha-actinin binding	IPI IPI: Inferred from physical interaction	20120020	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10826496	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	25158098	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	19307596	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	21636573	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21636573	GOA
located in cytoskeleton	IDA IDA: Inferred from direct assay	21636573	GOA
part of filamentous actin	IDA IDA: Inferred from direct assay	10826496	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	10826496	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10826496	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	19307596	GOA
located in stress fiber	IDA IDA: Inferred from direct assay	21636573	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDLIM4 Protein Structure

PDZ

LIM

0
100
200
300
330 a.a.

Protein Preferred Names	Protein Names
PDZ and LIM domain protein 4	LIM domain protein

PDLIM4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PDLIM4	P50479	FAM222B	Homo sapiens	Q8WU58	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Bone Mineral Density Quantitative Trait Locus 15	Osteoporosis BMND15 Osteoporosis, Susceptibility To Metaphyseal Fracture Metaphyseal Fracture, Susceptibility To Compression Fracture Compression Fracture, Susceptibility To Metaphyseal Fractures Fractures, Compression
Castration-Resistant Prostate Carcinoma	Prostatic Neoplasms, Castration-Resistant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10282	PDLIM4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PDLIM4	RGD	RGD:3575
Bos taurus	PDLIM4	VGNC	VGNC:32710
Canis familiaris	PDLIM4	VGNC	VGNC:44386
Felis catus	PDLIM4	VGNC	VGNC:64091
Macaca mulatta	PDLIM4	VGNC	VGNC:75809
Mus musculus	PDLIM4	MGD	MGI:1353470
Others	PDLIM4	NCBI