TNFRSF25 - TNF receptor superfamily member 25 Gene

Also Known as DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; GEF720; WSL-LR; PLEKHG5; TNFRSF12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8718

About TNFRSF25

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,460,786-6,466,173 (from NCBI)

This gene has 21 transcripts (splice variants), 461 orthologues and 21 paralogues. Broad expression in skin (RPKM 23.6), spleen (RPKM 13.2) and 19 other tissues.

Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell Apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]

TNFRSF25 Products (6)

mRNA Protein Name
NM_001039664.2 NP_001034753.1 tumor necrosis factor receptor superfamily member 25 isoform 12 precursor
NM_003790.3 NP_003781.1 tumor necrosis factor receptor superfamily member 25 isoform 2 precursor
NM_148965.2 NP_683866.1 tumor necrosis factor receptor superfamily member 25 isoform 1 precursor
NM_148966.2 NP_683867.1 tumor necrosis factor receptor superfamily member 25 isoform 3 precursor
NM_148967.2 NP_683868.1 tumor necrosis factor receptor superfamily member 25 isoform 4 precursor
NM_148970.2 NP_683871.1 tumor necrosis factor receptor superfamily member 25 isoform 7 precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
11911831 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFRSF25 Protein Structure

Death

Death: Death domain (334 - 411)

  • 0
  • 100
  • 200
  • 300
  • 417 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 25

  • Guanine nucleotide exchange factor 720

Recombinant TNFRSF25 Proteins

Cat. No. Product Name Accession Purity
HY-P72666 DR3/TNFRSF25 Protein, Human (HEK293, Fc) Q93038 (Q25-Q199) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77522 DR3/TNFRSF25 Protein, Human (Biotinylated, HEK293, Fc) Q93038 (Q25-Q199) ≥ 90%, as determined by reducing SDS-PAGE.

TNFRSF25 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84716 TNFRSF25 Antibody (YA4413) IHC-P, FC, ELISA Human
HY-P84716A TNFRSF25 Antibody (YA4413)(PBS only) IHC-P, FC, ELISA Human

Related Diseases

Diseases Alias
Type 1 Diabetes Mellitus 5

  • Diabetes Mellitus, Insulin-Dependent, 5

  • Latent Autoimmune Diabetes In Adults

  • IDDM5

  • Insulin-Dependent Diabetes Mellitus 5

  • T1D5

  • Lada

  • Type 1.5 Diabetes

  • Diabetes Mellitus, Insulin-Dependent, Type 5
Pemphigoid Gestationis

  • Herpes Gestationis

  • Gestational Pemphigoid

  • Gestational Herpes
Autoimmune Disease Of Endocrine System
Adrenal Cortical Hypofunction

  • Adrenal Cortical Insufficiency

  • Corticoadrenal Insufficiency
Juvenile Dermatitis Herpetiformis
Amelogenesis Imperfecta, Type Ib

  • AI1B

  • Aih2

  • Amelogenesis Imperfecta Type 1b

  • Amelogenesis Imperfecta Type Ib

  • Hereditary Localized Enamel Hypoplasia

  • Amelogenesis Imperfecta - Hypoplastic Autosomal Dominant - Local

  • Amelogenesis Imperfecta, Hypoplastic Local, Autosomal Dominant

  • Enamel Hypoplasia, Hereditary Localized

  • Autosomal Dominant Hypoplastic Local Amelogenesis Imperfecta

  • Amelogenesis Imperfecta 1b

  • Amelogenesis Imperfecta Hypoplastic 2

  • Amelogenesis Imperfecta Hypoplastic Local Autosomal Dominant
Amelogenesis Imperfecta, Type Ie

  • Aih1

  • Amelogenesis Imperfecta Type 1e

  • AI1E

  • Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1

  • Amelogenesis Imperfecta, Hypomaturation Type, With Snow-Capped Teeth

  • Enamel Hypoplasia, X-Linked

  • Amelogenesis Imperfecta Type Ie

  • Amelogenesis Imperfecta Hypoplastic/Hypomaturation X-Linked 1

  • Enamel Hypoplasia X-Linked

  • Amelogenesis Imperfecta, X-Linked 1

  • Amelogenesis Imperfecta, Type 1e

  • Amelogenesis Imperfecta Hypomaturationtype With Snow-Capped Teeth

  • X-Linked Amelogenesis Imperfecta 1

  • X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 1

  • X-Linked Enamel Hypoplasia

  • Amelogenesis Imperfecta X-Linked 1

  • Amelogenesis Imperfecta 1e

  • Amelogenesis Imperfecta, Hypoplastic/Hypomaturation Type 1e

  • Amelogenesis Imperfecta Hypomaturation Type With Snow-Capped Teeth

  • Xai

  • X-Linked Amelogenesis Imperfecta

  • Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2
Thyroiditis

  • Inflammation Of Thyroid

  • Thyroiditis Nos
Haemophilus Meningitis

  • Meningitis, Haemophilus
Type 1 Diabetes Mellitus 17

  • Diabetes Mellitus, Insulin-Dependent, 17

  • Iddm17

  • Insulin-Dependent Diabetes Mellitus 17

  • TID17

  • Insulin-Dependent Diabetes Mellitus-17
Heart Block, Congenital

  • Congenital Heart Block

  • Heart Block Congenital

  • Congenital Atrioventricular Block
Type 1 Diabetes Mellitus

  • Diabetes Mellitus, Insulin-Dependent

  • Diabetes Mellitus Type 1

  • IDDM

  • Type 1 Diabetes

  • Insulin-Dependent Diabetes Mellitus

  • T1D

  • Juvenile-Onset Diabetes

  • Jod

  • Diabetes Mellitus, Type 1

  • Diabetes Mellitus, Insulin-Dependent-1

  • Type I Diabetes Mellitus

  • Autoimmune Diabetes

  • Juvenile Diabetes

  • Juvenile-Onset Diabetes Mellitus

  • Diabetes, Insulin Dependent

  • Insulin-Dependent Diabetes Mellitus-1

  • Diabetes Mellitus Insulin-Dependent

  • Diabetes Autoimmune

  • Diabetes Mellitus, Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 1, Susceptibility To

  • Diabetes Type 1

  • Type I Diabetes

  • Diabetes, Autoimmune

  • T1dm - [Type 1 Diabetes Mellitus]

  • Iddm - [Insulin Dependent Diabetes Mellitus]

  • Type 1 Iddm

  • Juvenile Diabetes Mellitus Without Compications

  • Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

  • Juvenile-Onset Diabetes Mellitus Without Compications

  • Ketosis-Prone Diabetes Mellitus Without Compications

  • Juvenile-Onset-Type Diabetes Mellitus Without Compications
Immunoglobulin Alpha Deficiency

  • Iga Deficiency

  • Gamma-A-Globulin Deficiency

  • Immunoglobulin A Deficiency
Autoimmune Polyendocrine Syndrome, Type Ii

  • Schmidt Syndrome

  • Autoimmune Polyendocrine Syndrome Type 2

  • APS2

  • Autoimmune Polyglandular Syndrome Type 2

  • Diabetes Mellitus, Addison Disease, Myxedema

  • Polyglandular Autoimmune Syndrome, Type Ii

  • Pga Ii

  • Polyendocrine Autoimmune Syndrome, Type Ii

  • Aps Ii

  • Autoimmune Polyglandular Syndrome Type Ii

  • Diabetes Mellitus, Addison'S Disease, Myxedema

  • Multiple Endocrine Deficiency Syndrome, Type 2

  • Pga 2

  • Pga-Ii

  • Polyglandular Autoimmune Syndrome, Type 2

  • Polyglandular Deficiency Syndrome Type 2

  • Schmidt'S Syndrome

  • Autoimmune Polyendocrinopathy Type 2

  • Aps Type 2

  • Autoimmune Thyroid Disease And/Or Type 1 Diabetes-Addison Disease Syndrome

  • Autoimmune Syndrome Type Ii Polyglandular

  • Autoimmune Syndrome Type Ii, Polyglandular
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Bird Fancier'S Lung

  • Bird Fancier Lung

  • Pigeon Breeder'S Lung

  • Avian Hypersensitivity Pneumonitis

  • Bird Breeder'S Lung

  • Bird-Fancier'S Lung

  • Bird-Fanciers' Lung

  • Poultry Worker'S Lung

  • Pigeon-Breeder Lung Disease

  • Pigeon Breeders Lung

  • Avian Protein Hypersensitivity

  • Bird Breeders' Disease

  • Bird Breeders' Lung

  • Bird Fanciers' Lung

  • Bird Fanciers' Disease

  • Bfl - [Bird Fancier Lung]

  • Fanciers' Disease

  • Fanciers' Lung
Immunoglobulin A Deficiency 1

  • Immunoglobulin A Deficiency

  • Selective Iga Deficiency Disease

  • Selective Immunoglobulin A Deficiency

  • IGAD1

  • Immunoglobulin A, Selective Deficiency Of

  • Iga, Selective Deficiency Of

  • Gamma-A-Globulin, Selective Deficiency Of

  • Selective Iga Immunodeficiency

  • Selective Iga Deficiency

  • Iga Deficiency Selective
Robinow Syndrome, Autosomal Dominant 1

  • Autosomal Dominant Robinow Syndrome 1

  • DRS1

  • Robinow Dwarfism

  • Fetal Face Syndrome

  • Acral Dysostosis With Facial And Genital Abnormalities

  • Robinow, Autosomal Dominant Syndrome, Type 1
Parotid Disease

  • Parotid Diseases
Pernicious Anemia

  • Anemia, Pernicious

  • Anemia Pernicious

  • Pernicious Anaemia

  • Addison'S Anaemia

  • Biermer'S Anaemia

  • Biermer'S Anemia

  • Acquired Pernicious Anemia

  • Addison-Biermer Anemia

  • Addisonian Anemia

  • Biermer Anemia

  • Biermer'S Disease

  • Juvenile Onset Pernicious Anemia

  • Biermer Disease

  • Biermer-Addison Disease
Punctate Epithelial Keratoconjunctivitis

  • Punctate Keratitis

  • Thygeson Superficial Punctate Keratitis

  • Thygeson'S Superficial Punctate Keratitis

  • Thygeson Superficial Punctate Keratopathy

  • Punctate Epithelial Keratitis
Autoimmune Disease Of Gastrointestinal Tract
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Lymphocytic Colitis

  • Colitis, Lymphocytic
Type 1 Diabetes Mellitus 15

  • Diabetes Mellitus, Insulin-Dependent, 15

  • Iddm15

  • Insulin-Dependent Diabetes Mellitus 15

  • T1D15

  • Insulin-Dependent Diabetes Mellitus-15
Adrenal Cortex Disease

  • Adrenal Cortex Diseases
Lymphoid Interstitial Pneumonia

  • Lymphocytic Interstitial Pneumonia

  • Lip Disease

  • Lip Diseases

  • LIP

  • Disease Of Lips
Sclerosing Cholangitis

  • Fibrosing Cholangitis

  • Cholangitis, Sclerosing

  • Primary Sclerosing Cholangitis
Hashimoto Thyroiditis

  • Autoimmune Thyroiditis

  • Hashimoto Struma

  • Hashimoto'S Thyroiditis

  • Chronic Lymphocytic Thyroiditis

  • Lymphocytic Thyroiditis

  • Hashimoto Disease

  • Ht

  • Hashimoto'S Disease

  • Hashimoto'S Syndrome

  • Hypothyroidism, Autoimmune

  • Autoimmune Chronic Lymphocytic Thyroiditis

  • Chronic Lymphocytic Thyroiditides

  • Hashimoto Syndrome

  • Hashimotos Thyroiditis

  • Hashimoto Thyroiditis, Susceptibility To

  • Thyroiditis, Autoimmune

  • Lymphomatous Thyroiditis

  • Lymphoid Thyroiditis

  • Chronic Lymphadenoid Thyroiditis

  • Autoimmune Lymphocytic Chronic Thyroiditis

  • Goitre Lymphomatosa

  • Hashitoxicosis

  • Hashimoto Hypothyroidism

  • Lymphadenoid Goitre

  • Struma Lymphomatosa

  • Hyperthyroidism With Hashimoto Disease

  • Hashimoto Thyrotoxicosis

  • Thyrotoxicosis Due To Hashimoto Thyroiditis

  • Struma Lymphomatosis

  • Lymphadenoid Struma
Type 1 Diabetes Mellitus 12

  • Diabetes Mellitus, Insulin-Dependent, 12

  • IDDM12

  • Insulin-Dependent Diabetes Mellitus 12

  • T1D12

  • Type 1 Diabetes Mellitus 12, Susceptibility To

  • Diabetes Mellitus, Insulin-Dependent, Type 12
Cholangitis, Primary Sclerosing

  • Primary Sclerosing Cholangitis

  • PSC

  • Sclerosing Cholangitis

  • Cholangitis, Sclerosing

  • Cholangitis Primary Sclerosing

  • Psc - [Primary Sclerosing Cholangitis]
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Invasive Malignant Thymoma

  • Infiltrating Thymoma

  • Thymoma Malignant Invasive

  • Invasive Thymoma And Thymic Carcinoma
Diabetes Mellitus

  • Diabetes
Potocki-Shaffer Syndrome

  • Proximal 11p Deletion Syndrome

  • Chromosome 11p11.2 Deletion Syndrome

  • Pss

  • 11p11.2 Deletion

  • P11pds

  • Defect11 Syndrome

  • Deletion Of Chromosome 11p11.2

  • POSHS
Primary Biliary Cholangitis

  • Primary Biliary Cirrhosis

  • Biliary Liver Cirrhosis

  • Chronic Nonsuppurative Destructive Cholangitis

  • Familial Primary Biliary Cirrhosis

  • Pbc

  • Hanot Syndrome

  • Cholestatic Cirrhosis

  • Biliary Cirrhosis Primary

  • Liver Cirrhosis, Biliary

  • Hanot'S Cirrhosis

  • Biliary Cirrhosis

  • Pericholangiolic Biliary Cirrhosis

  • Tannhauser-Magendantz Syndrome

  • Hanot-Rossle Syndrome

  • Hypertrophic Cirrhosis

  • Todd Cirrhosis

  • Hanot Cirrhosis

  • Charcot Cirrhosis

  • Mahon-Tannhauser Syndrome

  • Toxic Cirrhosis

  • Hypertrophic Biliary Cirrhosis

  • Monolobular Cirrhosis

  • Unilobar Cirrhosis

  • Xanthomatous Biliary Cirrhosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P991455 PTX-35 Agonist 98.95% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14813 TNFRSF25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19293 Tnfrsf25 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25783 Tnfrsf25 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TNFRSF25 MGD MGI:1934667
Rattus norvegicus TNFRSF25 RGD RGD:1598206
Felis catus TNFRSF25 VGNC VGNC:66410
Macaca mulatta TNFRSF25 VGNC VGNC:78584
Canis familiaris TNFRSF25 VGNC VGNC:47664
Bos taurus TNFRSF25 VGNC VGNC:36167
Others TNFRSF25 NCBI