SKAP2 - src kinase associated phosphoprotein 2 Gene

Also Known as PRAP; RA70; SAPS; SCAP2; SKAP55R; SKAP-HOM

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8935

About SKAP2

Cytogenetic location: 7p15.2 Genomic coordinates (GRCh38): 7:26,654,770-26,864,590 (from NCBI)

This gene has 9 transcripts (splice variants), 204 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 10.6), appendix (RPKM 9.8) and 24 other tissues.

Summary

The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

SKAP2 Products (2)

mRNA	Protein	Name
NM_001303468.2	NP_001290397.1	src kinase-associated phosphoprotein 2 isoform 2
NM_003930.5	NP_003921.2	src kinase-associated phosphoprotein 2 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21719704	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	11390434	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SKAP2 Protein Structure

PH

SH3_9

0
100
200
300
359 a.a.

Protein Preferred Names	Protein Names
src kinase-associated phosphoprotein 2	Fyn-associated phosphoprotein SKAP55 homologue

SKAP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SKAP2	O75563	PTPN22	Homo sapiens	Q9Y2R2	Phosphatase Assay	21719704
Intra	SKAP2	O75563	EGFR	Homo sapiens	P00533	Anti Tag CoIP	27956147
Intra	SKAP2	O75563	EGFR	Homo sapiens	P00533	Ub Reconstruction	27956147

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Oral Candidiasis	Thrush Candidiasis Of Mouth Oral Moniliasis Thrush, Oral Candidiasis, Oral Oral Thrush Candidiasis Equine Thrush
Candidiasis	Systemic Candidiasis Invasive Candidiasis Disseminated Candidiasis Systemic Candida Infections Candidiasis, Invasive
Vertebrobasilar Insufficiency	Vertebro-Basilar Insufficiency Vertebrobasilar Arterial Insufficiency Vertebrobasilar Artery Syndrome
Candida Glabrata	Torulopsis Glabrata
Spinocerebellar Ataxia, Autosomal Recessive 3	SCAR3 Scabd Autosomal Recessive Spinocerebellar Ataxia Type 3 Autosomal Recessive Spinocerebellar Ataxia-Blindness-Deafness Syndrome Autosomal Recessive Spinocerebellar Ataxia-Blindness-Hearing Loss Syndrome Spinocerebellar Ataxia With Blindness And Deafness Autosomal Recessive Spinocerebellar Ataxia 3 Spinocerebellar Ataxia Autosomal Recessive 3 Autosomal Recessive Cerebellar Ataxia - Blindness - Deafness Autosomal Recessive Cerebellar Ataxia-Blindness-Deafness Syndrome
Hand-Foot-Genital Syndrome	Hand-Foot-Uterus Syndrome Hfgs Hfg Syndrome Hfu Syndrome HFG Hfu Hand Foot Uterus Syndrome Hand Foot Genital Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12968	SKAP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22806	Skap2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29321	Skap2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SKAP2	RGD	RGD:620159
Mus musculus	SKAP2	MGD	MGI:1889206
Canis familiaris	SKAP2	VGNC	VGNC:46197
Felis catus	SKAP2	VGNC	VGNC:65170
Bos taurus	SKAP2	VGNC	VGNC:34646
Macaca mulatta	SKAP2	VGNC	VGNC:77488
Others	SKAP2	NCBI