CD1D - CD1d molecule Gene

Homo sapiens

Also known as R3; CD1A; R3G1

Gene ID: 912 | Gene type: protein coding

About CD1D

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:158,178,030-158,186,427 (from NCBI)

This gene has 7 transcripts (splice variants), 429 orthologues and 22 paralogues. Broad expression in appendix (RPKM 5.0), spleen (RPKM 5.0) and 17 other tissues.

Summary

This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

CD1D Products(5)

mRNA	Protein	Name
NM_001319145.2	NP_001306074.1	antigen-presenting glycoprotein CD1d isoform 2 precursor
NM_001371761.1	NP_001358690.1	antigen-presenting glycoprotein CD1d isoform 3
NM_001371762.2	NP_001358691.1	antigen-presenting glycoprotein CD1d isoform 1 precursor
NM_001371763.1	NP_001358692.1	antigen-presenting glycoprotein CD1d isoform 1 precursor
NM_001766.4	NP_001757.1	antigen-presenting glycoprotein CD1d isoform 1 precursor

CD1D Protein Structure

C1-set

0
100
200
300
335 a.a.

Protein Preferred Names

Protein Names

antigen-presenting glycoprotein CD1d

CD1D antigen, d polypeptide

Recombinant CD1D Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74326	CD1D-B2M Heterodimer Protein, Human (HEK293, His)	P15813 (E20-S301)&P61769 (I21-M119)	≥95%
HY-P74327	CD1D Protein, Human (HEK293, His)	P15813 (M1-S301)	≥95%

Related Diseases

Diseases

Alias

Follicular Dendritic Cell Sarcoma

Dendritic Cell Sarcoma	Dendritic Cell Sarcoma, Follicular
Follicular Dendritic Cell Tumour	Dendritic Cell Sarcoma, Interdigitating
Dendritic Cell Sarcoma, Not Otherwise Specified

Non-Langerhans-Cell Histiocytosis

Histiocytosis, Non-Langerhans-Cell

Non-Langerhans Cell Histiocytosis

Langerhans Cell Sarcoma

Malignant Langerhans Cell Sarcoma

Histiocytic And Dendritic Cell Cancer

Histiocytic And Dendritic Cell

Juvenile Xanthogranuloma

Multiple Eruptive Juvenile Xanthogranuloma	Naevoxanthoendothelioma
Xanthoma Neviforme	Xanthogranuloma, Juvenile

Interdigitating Dendritic Cell Sarcoma

Interdigitating Cell Sarcoma	Dendritic Cell Sarcoma, Interdigitating
Reticulum Cell Sarcoma

Adult Xanthogranuloma

Multicentric Reticulohistiocytosis

Lipoid Dermatoarthritis

Giant Cell Histiocytomatosis

Rhinoscleroma

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Reticulohistiocytic Granuloma

Reticulohistiocytoma	Solitary Reticulohistiocytoma
Solitary Histiocytoma	Solitary Reticulohistiocytosis

Langerhans Cell Histiocytosis

Histiocytosis X	Lch
Langerhans Cell Granulomatosis	Langerhans-Cell Histiocytosis
Letterer-Siwe Disease	Hashimoto-Pritzger Disease
Histiocytosis, Langerhans-Cell	Langerhan'S Cell Histiocytosis
Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes	Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes
Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes	Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb
Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck	Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck
Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb	Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites
Letterer-Siwe Disease Involving Spleen	Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes
Letterer-Siwe Disease Of Intrapelvic Lymph Nodes	Letterer-Siwe Disease Of Intrathoracic Lymph Nodes
Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb	Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb
Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck	Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck
Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb	Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb
Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites
Letterer-Siwe Disease Of Spleen	Familial Letterer-Siwe Disease
Langerhans-Cell Histiocytosis Nos

Fibrosarcoma Of Bone

Malignant Histiocytosis	Malignant Fibroxanthoma
Malignant Fibrous Histiocytoma	Histiocytic Medullary Reticulosis
Nasal Type Extranodal Nk/T-Cell Lymphoma	Histiocytic Sarcoma

Granuloma Annulare

Granulome Annulare

Ga - [Granuloma Annulare]

Histiocytosis-Lymphadenopathy Plus Syndrome

H Syndrome	Histiocytosis With Joint Contractures And Sensorineural Deafness
Faisalabad Histiocytosis	Shml
Hjcd	Rosai-Dorfman Disease
Pigmented Hypertrichosis With Insulin-Dependent Diabetes Mellitus	Phid
Sinus Histiocytosis And Massive Lymphadenopathy	Familial Rosai-Dorfman Disease
Slc29a3 Spectrum Disorder	Sinus Histiocytosis With Massive Lymphadenopathy
Histiocytosis And Lymphadenopathy With Or Without Cutaneous, Cardiac, And/Or Endocrine Features, Joint Contractures, And/Or Deafness	Hyperpigmentation, Cutaneous, With Hypertrichosis, Hepatosplenomegaly, Heart Anomalies, And Hypogonadism With Or Without Hearing Loss
Rosai-Dorfman Disease, Familial	Cutaneous Hyperpigmentation With Hypertrichosis, Hepatosplenomegaly, Heart Anomalies, And Hypogonadism With Or Without Hearing Loss
Histiocytosis And Lymphadenopathy With Or Without Cutaneous, Cardiac, And/Or Endocrine Features, Joint Contractures And/Or Deafness	Rdd
Rosaï-Dorfman Disease	Slc29a3 Disorder
Destombes-Rosai-Dorfman Disease	Rosai-Dorfman-Destombes Disease
HLAS	Cutaneous Hyperpigmentation With Hypertrichosis Hepatosplenomegaly Heart Anomalies And Hypogonadism With Or Without Hearing Loss
Histiocytosis And Lymphadenopathy With Or Without Cutaneous Cardiac And/Or Endocrine Features Joint Contractures And/Or Deafness	H Disease
Sinus Histiocytosis

Orbital Cancer

Malignant Neoplasm Of Orbit	Orbital Tumor
Orbital Neoplasms	Neoplasm Of Orbit Proper
Orbit Cancer	Primary Malignant Neoplasm Of Orbit
Intraorbital Cancer

Lymphoid Interstitial Pneumonia

Lymphocytic Interstitial Pneumonia	Lip Disease
Lip Diseases	LIP
Disease Of Lips

Chronic Laryngitis

Polyclonal Hypergammaglobulinemia

Polyclonal Gammopathy

Cobblestone Retinal Degeneration

Paving Stone Retinal Degeneration

Paving Stone Degeneration Of Retina

Spongiotic Dermatitis

Histiocytic Sarcoma

Malignant Histiocytosis

Central Diabetes Insipidus

Neurogenic Diabetes Insipidus	Diabetes Insipidus Cranial Type
Diabetes Insipidus Neurogenic	Diabetes Insipidus Neurohypophyseal
Neurohypophyseal Diabetes Insipidus	Pituitary Diabetes Insipidus
Cdi	Doid:0081055
Diabetes Insipidus	Di - [Diabetes Insipidus]
Adh - [Antidiuretic Hormone Secretion] Deficiency	Diabetes Mellitus Insipidus
Familial Diabetes Insipidus	Antidiuretic Hormone Hyposecretion
Vasopressin Deficiency Syndrome	Primary Central Diabetes Insipidus
Vasopressin Deficiency	Vasopressin Hyposecretion
Diabetes Insipidus Secondary To Vasopressin Deficiency

Exophthalmos

Proptosis

Periampullary Adenocarcinoma

Seborrheic Dermatitis

Seborrhoeic Dermatitis	Seborrhea
Seborrhoeic Eczema	Skin Seborrheic
Dermatitis, Seborrheic

Malignant Histiocytic Disease

Histiocytic Disorders, Malignant

Granulomatous Dermatitis

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Large Cell Acanthoma

Orbital Disease

Orbit

Orbital Diseases

Frontal Sinus Benign Neoplasm

Neoplasm Of Frontal Sinus

Tumor Of The Frontal Sinus

Lichen Disease

T-Cell Prolymphocytic Leukemia

T Cell Prolymphocytic Leukemia	Prolymphocytic Leukemia, T-Cell Type
T-Pll	T-Cell Chronic Lymphocytic Leukemia
Lymphocytic Leukemia T-Cell Chronic	Doid:0081042
Leukemia, T-Cell, Chronic	Prolymphocytic Leukaemia Of T-Cell Type Without Mention Of Remission

Balloon Cell Malignant Melanoma

Diencephalic Astrocytoma

Astrocytoma Of Diencephalon

Beach Ear

Acute Swimmer'S Ear	Acute Bacterial Inflammation Of External Ear
Acute Otitis Externa, Diffuse	Acute Swimmers' Ear
Tank Ear

Keratosis, Seborrheic

Seborrheic Keratosis	Keratosis, Seborrheic, Somatic
Basal Cell Papilloma	Keratosis Seborrheica
KERSEB

Thymus Gland Disease

Disease Of Thymus Gland

Thymus Cancer

Thymic Neoplasm	Thymic Tumor
Thymus Neoplasm	Thymus Neoplasms
Malignant Neoplasm Of Thymus	Neoplasm Of Thymus
Thymic Neoplasms	Thymoma, Familial
Thymic Carcinoma	Thymoma, Type C
Cancer Of Thymus	Malignant Tumour Of Thymus
Primary Malignant Neoplasm Of Thymus	Thymic Glandular Cancer
Thymus Gland Cancer

Leprosy 3

Leprosy	Leprosy, Susceptibility To, 3
Hansen'S Disease	Leprosy, Susceptibility To
Hansen Disease	Infection Due To Mycobacterium Leprae
LPRS3	Leprosy, Type 3
Anaesthesia Leprosy	Anaesthetic Leprosy
Maculoanaesthetic Leprosy	Macular Leprosy
Leprosy Unspecified

Vulvar Proximal-Type Epithelioid Sarcoma

Central Epithelioid Sarcoma

Proximal-Type Epithelioid Sarcoma

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-102022	α-Galactosylceramide		95.59%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02202	CD1D Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CD1D	VGNC	VGNC:53116
Macaca mulatta	CD1D	VGNC	VGNC:70757
Rattus norvegicus	CD1D	RGD	RGD:2296
Mus musculus	CD1D	NCBI
Others	CD1D	NCBI