CNOT9 - CCR4-NOT transcription complex subunit 9 Gene

Also Known as RCD1; CAF40; CT129; RCD-1; RQCD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9125

About CNOT9

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,568,839-218,597,080 (from NCBI)

This gene has 9 transcripts (splice variants) and 241 orthologues. Ubiquitous expression in testis (RPKM 10.4), lymph node (RPKM 9.1) and 25 other tissues.

Summary

This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012]

CNOT9 Products (3)

mRNA Protein Name
NM_001271634.2 NP_001258563.1 CCR4-NOT transcription complex subunit 9 isoform 1
NM_001271635.2 NP_001258564.1 CCR4-NOT transcription complex subunit 9 isoform 3
NM_005444.3 NP_005435.1 CCR4-NOT transcription complex subunit 9 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables epidermal growth factor receptor binding IPI
IPI: Inferred from physical interaction
20878056 GOA
enables kinase binding IPI
IPI: Inferred from physical interaction
20878056 GOA
enables nuclear receptor coactivator activity IDA
IDA: Inferred from direct assay
18180299 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18180299 GOA
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
24768540 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
24768540 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in negative regulation of intracellular estrogen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16778766 GOA
involved in positive regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
20878056 GOA
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
20878056 GOA
Cellular Component GO Annotation Evidence Referencias Source
part of CCR4-NOT complex IDA
IDA: Inferred from direct assay
19558367 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
20878056 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNOT9 Protein Structure

Rcd1

Rcd1: Cell differentiation family, Rcd1-like (24 - 285)

  • 0
  • 100
  • 200
  • 299 a.a.
Protein Preferred Names Protein Names

CCR4-NOT transcription complex subunit 9

  • RCD1 required for cell differentiation1 homolog

CNOT9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Referencias
Intra
CNOT9 Q92600 CNOT6L Homo sapiens Q96LI5
Anti Tag CoIP
17452450
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Suppression Of Tumorigenicity 12

  • Prostate Adenocarcinoma

  • Adenocarcinoma Of Prostate

  • ST12

  • Prostate Adenocarcinoma 1

  • Pac1
Skin Melanoma

  • Cutaneous Melanoma

  • Malignant Ear Melanoma

  • Malignant Lip Melanoma

  • Malignant Lower Limb Melanoma

  • Malignant Melanoma Of Ear And/Or External Auricular Canal

  • Malignant Melanoma Of Skin Of Lower Limb

  • Malignant Melanoma Of Skin Of Trunk Except Scrotum

  • Malignant Melanoma Of Skin Of Upper Limb

  • Malignant Neck Melanoma

  • Malignant Scalp Melanoma

  • Malignant Trunk Melanoma

  • Malignant Upper Limb Melanoma

  • Melanoma, Cutaneous Malignant

  • Melanoma

  • Malignant Melanoma Of Skin

  • Melanoma Nos

  • Malignant Mole, Meaning Melanoma Of Unspecified Site

  • Melanoma Of Unspecified Site

  • Cutaneous Malignant Melanoma

  • Mm - [Malignant Melanoma]
Gastric Adenocarcinoma

  • Adenocarcinoma Of Stomach

  • Stomach Adenocarcinoma

  • Adenocarcinoma Gastric

  • Intestinal Type Adenocarcinoma Of Unspecified Site

  • Diffuse Type Adenocarcinoma Of Unspecified Site
Bladder Urothelial Carcinoma

  • Bladder Transitional Cell Carcinoma

  • Transitional Cell Carcinoma Of Bladder

  • Transitional Cell Carcinoma Of The Bladder

  • Urinary Bladder Urothelial Carcinoma

  • Urothelial Bladder Carcinoma

  • Carcinoma Transitional Cell Bladder

  • Tcc - [Transitional Cell Carcinoma] Of Bladder
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS02909 CNOT9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CNOT9 VGNC VGNC:71165
Canis familiaris CNOT9 VGNC VGNC:39420
Mus musculus CNOT9 MGD MGI:1928902
Rattus norvegicus CNOT9 RGD RGD:1311495
Felis catus CNOT9 VGNC VGNC:80171
Bos taurus CNOT9 VGNC VGNC:27524
Others CNOT9 NCBI