SOX13 - SRY-box transcription factor 13 Gene

Also Known as ICA12; Sox-13

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9580

About SOX13

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:204,073,115-204,127,743 (from NCBI)

This gene has 10 transcripts (splice variants), 212 orthologues and 20 paralogues. Ubiquitous expression in placenta (RPKM 12.7), endometrium (RPKM 11.6) and 24 other tissues.

Summary

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with Other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12. [provided by RefSeq, Jul 2008]

SOX13 Products (1)

mRNA	Protein	Name
NM_005686.3	NP_005677.2	transcription factor SOX-13

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	10871192	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	20028982	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	10871192	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17218525	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	26525805	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20028982	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20028982	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20028982	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10871192	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SOX13 Protein Structure

HMG_box

0
100
200
300
400
500
622 a.a.

Protein Preferred Names	Protein Names
transcription factor SOX-13	SRY (sex determining region Y)-box 13

SOX13 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SOX13	Q9UN79	CTBP2	Homo sapiens	P56545	Anti Tag CoIP	33961781
Intra	SOX13	Q9UN79	CTBP2	Homo sapiens	P56545	Y2H	21988832
Intra	SOX13	Q9UN79	CTBP2	Homo sapiens	P56545	Anti Tag CoIP	21988832

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Type 1 Diabetes Mellitus 5	Diabetes Mellitus, Insulin-Dependent, 5 Latent Autoimmune Diabetes In Adults IDDM5 Insulin-Dependent Diabetes Mellitus 5 T1D5 Lada Type 1.5 Diabetes Diabetes Mellitus, Insulin-Dependent, Type 5

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13586	SOX13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SOX13	VGNC	VGNC:35142
Mus musculus	SOX13	MGD	MGI:98361
Rattus norvegicus	SOX13	RGD	RGD:1309674
Felis catus	SOX13	VGNC	VGNC:65579
Macaca mulatta	SOX13	VGNC	VGNC:77839
Canis familiaris	SOX13	VGNC	VGNC:46674
Others	SOX13	NCBI