FEZ2 - fasciculation and elongation protein zeta 2 Gene

Homo sapiens

Also known as HUM3CL

Gene ID: 9637 | Gene type: protein coding

About FEZ2

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:36,552,258-36,598,168 (from NCBI)

This gene has 16 transcripts (splice variants), 274 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 32.7), brain (RPKM 29.1) and 24 other tissues.

Summary

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008]

FEZ2 Products(2)

mRNA	Protein	Name
NM_001042548.2	NP_001036013.1	fasciculation and elongation protein zeta-2 isoform 2
NM_005102.3	NP_005093.2	fasciculation and elongation protein zeta-2 isoform 1

FEZ2 Protein Structure

FEZ

0
100
200
300
353 a.a.

Protein Preferred Names

Protein Names

fasciculation and elongation protein zeta-2

pre-T/NK cell associated protein (3Cl)

Related Diseases

Diseases

Alias

Martsolf Syndrome 1

Martsolf Syndrome	Cataract-Intellectual Disability-Hypogonadism Syndrome
MARTS1	Marts
Cataract-Mental Retardation-Hypogonadism	Martsolf

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04871	FEZ2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FEZ2	MGD	MGI:2675856
Rattus norvegicus	FEZ2	RGD	RGD:619709
Bos taurus	FEZ2	VGNC	VGNC:28958
Macaca mulatta	FEZ2	VGNC	VGNC:72640
Canis familiaris	FEZ2	VGNC	VGNC:40828
Felis catus	FEZ2	VGNC	VGNC:109565