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FEZ2 - fasciculation and elongation protein zeta 2 Gene

Also Known as HUM3CL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9637

About FEZ2

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:36,552,258-36,598,168 (from NCBI)

This gene has 16 transcripts (splice variants), 274 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 32.7), brain (RPKM 29.1) and 24 other tissues.

Summary

This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orthologs include the rat gene that encodes zygin II, which can bind to synaptotagmin. [provided by RefSeq, Jul 2008]

FEZ2 Products (2)

mRNA	Protein	Name
NM_001042548.2	NP_001036013.1	fasciculation and elongation protein zeta-2 isoform 2
NM_005102.3	NP_005093.2	fasciculation and elongation protein zeta-2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14690447	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	25495476	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FEZ2 Protein Structure

FEZ

0
100
200
300
353 a.a.

Protein Preferred Names	Protein Names
fasciculation and elongation protein zeta-2	pre-T/NK cell associated protein (3Cl)

FEZ2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FEZ2	Q9UHY8	SCOC	Homo sapiens	Q9UIL1-3	Validated Y2H	32296183
Intra	FEZ2	Q9UHY8	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	FEZ2	Q9UHY8	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	FEZ2	Q9UHY8	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	FEZ2	Q9UHY8	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	FEZ2	Q9UHY8	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	FEZ2	Q9UHY8	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	FEZ2	Q9UHY8	PSEN1	Homo sapiens	P49768-2	Validated Y2H	32814053
Intra	FEZ2	Q9UHY8	PSEN1	Homo sapiens	P49768-2	Y2H Array	32814053
Intra	FEZ2	Q9UHY8	PSEN1	Homo sapiens	P49768-2	Y2H Pooling	32814053
Intra	FEZ2	Q9UHY8	APP	Homo sapiens	P05067-2	Validated Y2H	32814053
Intra	FEZ2	Q9UHY8	APP	Homo sapiens	P05067-2	Y2H Array	32814053
Intra	FEZ2	Q9UHY8	APP	Homo sapiens	P05067-2	Y2H Pooling	32814053
Intra	FEZ2	Q9UHY8	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
Intra	FEZ2	Q9UHY8	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
Intra	FEZ2	Q9UHY8	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
Intra	FEZ2	Q9UHY8	PINK1	Homo sapiens	Q9BXM7	Y2H Array	32814053
Intra	FEZ2	Q9UHY8	PINK1	Homo sapiens	Q9BXM7	Validated Y2H	32814053
Intra	FEZ2	Q9UHY8	PINK1	Homo sapiens	Q9BXM7	Y2H Pooling	32814053
Intra	FEZ2	Q9UHY8	NEK1	Homo sapiens	Q96PY6	Pull Down	14690447
Intra	FEZ2	Q9UHY8	NEK1	Homo sapiens	Q96PY6	Y2H	14690447
Intra	FEZ2	Q9UHY8	SMN1	Homo sapiens	Q16637	Y2H Array	32814053
Intra	FEZ2	Q9UHY8	SMN1	Homo sapiens	Q16637	Validated Y2H	32814053
Intra	FEZ2	Q9UHY8	SMN1	Homo sapiens	Q16637	Y2H Pooling	32814053
Intra	FEZ2	Q9UHY8	ZDHHC17	Homo sapiens	Q8IUH5	Lumier	24705354
Intra	FEZ2	Q9UHY8	ZDHHC17	Homo sapiens	Q8IUH5	Y2H Array	24705354
Intra	FEZ2	Q9UHY8	TTR	Homo sapiens	P02766	Validated Y2H	32814053
Intra	FEZ2	Q9UHY8	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
Intra	FEZ2	Q9UHY8	TTR	Homo sapiens	P02766	Y2H Array	32814053
Intra	FEZ2	Q9UHY8	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	FEZ2	Q9UHY8	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	FEZ2	Q9UHY8	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	FEZ2	Q9UHY8	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	FEZ2	Q9UHY8	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	FEZ2	Q9UHY8	PRPS1	Homo sapiens	P60891	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Martsolf Syndrome 1	Martsolf Syndrome Cataract-Intellectual Disability-Hypogonadism Syndrome MARTS1 Marts Cataract-Mental Retardation-Hypogonadism Martsolf

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04871	FEZ2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FEZ2	MGD	MGI:2675856
Rattus norvegicus	FEZ2	RGD	RGD:619709
Bos taurus	FEZ2	VGNC	VGNC:28958
Macaca mulatta	FEZ2	VGNC	VGNC:72640
Canis familiaris	FEZ2	VGNC	VGNC:40828
Felis catus	FEZ2	VGNC	VGNC:109565
Others	FEZ2	NCBI