MTSS1 - MTSS I-BAR domain containing 1 Gene

Also Known as MIM; MIMA; MIMB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9788

About MTSS1

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:124,550,784-124,728,473 (from NCBI)

This gene has 18 transcripts (splice variants), 275 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 5.7), adrenal (RPKM 5.6) and 25 other tissues.

Summary

Enables actin monomer binding activity; identical protein binding activity; and signaling receptor binding activity. Predicted to be involved in cellular response to fluid shear stress; negative regulation of epithelial cell proliferation; and urogenital system development. Predicted to act upstream of or within several processes, including actin filament polymerization; adherens junction maintenance; and magnesium ion homeostasis. Located in actin Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

MTSS1 Products (12)

mRNA	Protein	Name
NM_001282971.2	NP_001269900.1	protein MTSS 1 isoform 1
NM_001282974.2	NP_001269903.1	protein MTSS 1 isoform 3
NM_001363294.2	NP_001350223.1	protein MTSS 1 isoform 4
NM_001363295.2	NP_001350224.1	protein MTSS 1 isoform 5
NM_001363296.2	NP_001350225.1	protein MTSS 1 isoform 6
NM_001363297.2	NP_001350226.1	protein MTSS 1 isoform 7
NM_001363298.2	NP_001350227.1	protein MTSS 1 isoform 8
NM_001363299.2	NP_001350228.1	protein MTSS 1 isoform 9
NM_001363300.2	NP_001350229.1	protein MTSS 1 isoform 10
NM_001363301.2	NP_001350230.1	protein MTSS 1 isoform 11
NM_001363302.2	NP_001350231.1	protein MTSS 1 isoform 12
NM_014751.6	NP_055566.3	protein MTSS 1 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin monomer binding	IDA IDA: Inferred from direct assay	12570871	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	14752106	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15383276	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	12570871	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	12570871	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTSS1 Protein Structure

IMD

WH2

0
200
400
600
755 a.a.

Protein Preferred Names	Protein Names
protein MTSS 1	MTSS1, I-BAR domain containing

MTSS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MTSS1	O43312	CTTN	Homo sapiens	Q14247	Pull Down	15688017
Intra	MTSS1	O43312	MTSS1	Homo sapiens	O43312	Anti Tag CoIP	14752106
Intra	MTSS1	O43312	q8d1p4_yerpe	Yersinia pestis	Q8D1P4	Y2H Pooling	20711500
Intra	MTSS1	O43312	MTSS1	Homo sapiens	O43312	Crosslink	14752106

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MTSS1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75930	MTSS1 Protein, Human (His)	EAW92073 (M1-S250)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Oropharyngeal Anthrax

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08820	MTSS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19719	Mtss1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26215	Mtss1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MTSS1	MGD	MGI:2384818
Canis familiaris	MTSS1	VGNC	VGNC:43493
Bos taurus	MTSS1	VGNC	VGNC:31752
Macaca mulatta	MTSS1	VGNC	VGNC:74995
Felis catus	MTSS1	VGNC	VGNC:63660
Rattus norvegicus	MTSS1	RGD	RGD:1309883
Others	MTSS1	NCBI