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Cat. No.: HY-109176R

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Giredestrant (Standard)

Name: Giredestrant (Standard)
Brand: MedChemExpress
SKU: HY-109176R
Availability: PreOrder

(Synonyms: GDC-9545 (Standard); RG6171 (Standard))

Giredestrant (Standard) (GDC-9545 (Standard); RG6171 (Standard)) is the analytical standard of Giredestrant (HY-109176). This product is intended for research and analytical applications. Giredestrant (GDC-9545) is an orally active, full, selective Estrogen receptor α (ERα) degrader and antagonist with a DC₅₀ of 0.03 nM. Giredestrant promotes the degradation of ERα protein, including the ESR1^Y537S mutant ERα. Giredestrant reduces uterine wet weight in immature rats and induces a low cuboidal phenotype in their endometrial epithelium. Giredestrant induces tumor regression in both ESR1^Y537S mutant and wild-type ERα tumor models. Giredestrant can be used for the research of ER⁺ breast cancer.

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CAS No.: 1953133-47-5
화학식: C₂₇H₃₁F₅N₄O
분자량:522.55

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Giredestrant (Standard) Chemical Structure

CAS No.: 1953133-47-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Product Information

Information

신청

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1953133-47-5
분자량 522.55
화학식 C₂₇H₃₁F₅N₄O
SMILES

OCC(F)(F)CN([C@@H]1C2=C(F)C=C(NC3CN(CCCF)C3)C=C2F)[C@H](C)CC4=C1NC5=C4C=CC=C5
Synonyms

GDC-9545 (Standard); RG6171 (Standard)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Liang J, et al. GDC-9545 (Giredestrant): A Potent and Orally Bioavailable Selective Estrogen Receptor Antagonist and Degrader with an Exceptional Preclinical Profile for ER+ Breast Cancer. Journal of medicinal chemistry. 2021 Aug 26;64(16):11841-11856. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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