Giredestrant (Standard)
Giredestrant (Standard) (GDC-9545 (Standard); RG6171 (Standard)) is the analytical standard of Giredestrant (HY-109176). This product is intended for research and analytical applications. Giredestrant (GDC-9545) is an orally active, full, selective Estrogen receptor α (ERα) degrader and antagonist with a DC50 of 0.03 nM. Giredestrant promotes the degradation of ERα protein, including the ESR1Y537S mutant ERα. Giredestrant reduces uterine wet weight in immature rats and induces a low cuboidal phenotype in their endometrial epithelium. Giredestrant induces tumor regression in both ESR1Y537S mutant and wild-type ERα tumor models. Giredestrant can be used for the research of ER+ breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 1953133-47-5
- Formula: C27H31F5N4O
- Molecular Weight:522.55
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Product Information
-
Chemical Information
- Purity & Documentation
-
Help & FAQs
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
-
CAS No. 1953133-47-5
-
Molecular Weight 522.55
-
Formula C27H31F5N4O
-
SMILES
OCC(F)(F)CN([C@@H]1C2=C(F)C=C(NC3CN(CCCF)C3)C=C2F)[C@H](C)CC4=C1NC5=C4C=CC=C5
-
Synonyms
GDC-9545 (Standard); RG6171 (Standard)
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Giredestrant (Standard) Related Classifications
HY-109176R Related Classifications
Powered by Bioz
- Giredestrant (Standard)
- 1953133-47-5
- GDC-9545 (Standard)
- RG6171 (Standard)
- Reference Standards
- Estrogen Receptor/ERR
- immature rats
- human liver microsomes
- T-47D wild-type breast cancer cells
- MCF-7 wild-type breast cancer cells
- ER+ breast cancer cells
- ERα
- ESR1 Y537S mutant ERα
- hERG channels
- estrogen receptor alpha
- rat liver microsomes
- Inhibitor
- inhibitor
- inhibit